COLORADO CHRONIC NECK PAIN RELIEF
"Instead of the roof of the subacromial space (the AC joint) coming down and pressing on the structures, I really think that most of it is that the floor (the glenoid ball of the shoulder) is coming up." This means that inferior glide of the humeral head is a must!
Watch as these same two physical therapists demonstrate four different orthopedic tests used to determine the likelihood that your shoulder problem is an impingement or something else (HERE).
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IS IT EVEN POSSIBLE FOR AUTHORS OF STUDIES OPPOSING MAINSTREAM MEDICAL THOUGHT TO BE HEARD IN THE PEER-REVIEWED LITERATURE?Read Now
IS IT POSSIBLE FOR ACADEMICS WITH "CONTRARIAN VIEWS" TO GET A FAIR SHAKE IN THE MEDICAL JOURNALS?
"Earlier this month, Dr Nicola Luigi Bragazzi --- a medical doctor with a Ph.D in nanochemistry and nanobiotechnology --- of Italy's University of Genoa, along with a group of researchers from the Zabludowicz Center for Autoimmune Diseases at Israel's Tel-Aviv University, published a study in the journal Vaccine called Debate on Vaccines and Autoimmunity: Do Not Attack the Author, Yet Discuss it Methodologically. As you might imagine from the study's title, Bragazzi and company are tired of taking it on the chin for publishing legitimate research findings that are not in lockstep with standard vaccine propaganda."
Taking it on the chin. Believe me when I tell you that many (many) researchers have taken and continue to "take it on the chin" for their views concerning any number of controversial topics (HERE and HERE are a couple of these individuals). Mind you, we are not talking about opinions here, but about research findings that don't necessarily jibe with current medial dogma (my post titled "MUZZLED" is another good example). For instance, in the comment section of Dr. Packer's article, Sydney Singer (author of a book I read years ago; DRESSED TO KILL) talked about the manner in which research showing health problems associated with bras (including BREAST CANCER) continues to be suppressed. As is typically the case, if you want to see real-time, real-life examples of this phenomenon in action, simply read the article's comment section.
Dr. Packer began his article by revealing something that many people are unaware of unless they regularly follow my EVIDENCE-BASED MEDICINE COLUMN; the fact that when it comes to medical research and the journals charged with both publishing it and getting it out to the medical community and the public at large, the problems run so deep that nothing, and I do mean nothing, can be trusted without first looking at numerous factors, including who paid for the study or HOW THE RESEARCH WAS DONE. After discussing what modern editorials in today's medical journals have become, Packer asked the question "Who loses?" Below is his CHERRY-PICKED response to this ETHICAL QUAGMIRE.
"All too often, it is the reader who loses. If readers were expecting enlightenment, a different perspective, or a contrary opinion from the editorial, more likely than not, they will be disappointed. What if the study is terribly flawed and the editorialist does not take notice? Can readers submit criticisms or an alternative viewpoint? They can certainly try, and I wish them luck. If you want to raise concerns about a published article, you could write a letter to the editor. But you need to work fast. Most editors will not accept letters that are submitted more than 3-6 weeks following publication. And they decide what letters get published. Many are reluctant to acknowledge errors. If you want to write a longer piece (i.e., an editorial) that is poised to disagree with a published article, you could send a request to the editors. But do not expect a positive reply. Even if you have valid criticism and points to make, the editors may not be receptive. Why would they publish an editorial that challenges their decision to have published the original work in the first place? Of course, you could decide to write a critical editorial and send it to a different journal. But often that will not work. Many journals have a standing policy that they will not consider editorials that are critical of work published in other journals. (Disclosure: I hold editorial positions at Circulation and the European Heart Jour"
Packer went on to discuss numerous other issues with the process, including the fact that the very people who will review your letter-to-the-editor are usually THE VERY PEOPLE WHO REVIEWED THE RESEARCH in the first place. Are they ready to "take it on the chin"? Doubtful. I don't know many people who like like getting punched in the face, including Packer himself. Not to pick on Dr. P because he is undoubtedly a guy I would enjoy shooting the breeze with on the CURRENT RIVER. But as an editor of the prestigious journal of the American Heart Association, Circulation, some would argue that Dr. Packer is doing the very same thing. Just remember not to ask Dr. Vasquez his opinion.
Although in certain circumstances he would fulfill the definition of a "contrarian" (something I've been accused of at times myself); as a person holding naturopathic, chiropractic and medical degrees as well as a post-doctorate fellowship in nutrition (not to mention the several areas of research he is actively involved in), Dr. Alex Vasquez is a sharp guy and formidable debate opponent. It makes me wonder whether at least one of his recent 'disagreements' with both the American College of Cardiology and the AHA (see below) ran through Packer's office. What am I talking about? Using some of Dr. Alex's recent articles, allow me to show you exactly how big journals are squelching "contrarian" opinions that might --- in these cases, "are" would be a better word --- upsetting the medical fruit basket.
- The ASCEND Study on Fish Oil from the New England Journal of Medicine (and touted by the ACC in their article, ASCEND: Use of Aspirin and Fish Oil Supplements in Diabetic Patients) fraudulently and unethically showed fish oil in a bad light for the sole purpose of promoting a new-fangled patented and medicalized version of fish oil (HERE and HERE). In fact, when I Googled "ASCEND Study Fish Oil", the first thing that came up was an ad for --- you guessed it --- the drug Vascepa
- Another study by the ACC, this one concerning nutritional supplements for heart disease, was challenged by Dr. Vasquez on his website. Why on his website? Because their journal refused to publish a rebuttal (HERE).
- Other research that Dr. Vasquez likewise weighed in on heavily was the AHA's 2017 study showing that coconut oil , as well as saturated fats in general, are harmful (HERE). For the record, I should note that my earlier "quagmire" link connects you with Dr. Alex's version of the "echo chamber" mentioned by Dr. Packer in his quote at the top of the page.
The point is this. Be careful who you believe, myself included. Double check everything and assume that online personalities are simply trying to sell you something until proven otherwise. As far as helping yourself with the root of most modern diseases, heart disease included, be sure and learn what it takes to start addressing systemic inflammation in your life (HERE). And if you appreciate what you are finding on our site, be sure and help spread the wealth by liking, sharing, or following on FACEBOOK since it's a viable way to reach the people you love and value most.
OAKLAND RAIDERS ARE PROFESSIONAL FOOTBALL'S GREATEST TEAM
SO SAYS MEDICAL RESEARCH
"So it is with much that you read and hear. Averages and relationships and trends and graphs are not always what they seem. There may be more in them than meets the eye, and there may be a good deal less." Darrell Huff from his famous 1954 book, How to Lie With Statistics
Even though the Raiders have the NFL's classiest receiver, Kansas State's Jordy Nelson, the truth is, they stink. Bad. As in get out the Lysol and spray the whole can. Playing in a division that was arguably the cream of this past season's crop --- the AFC West --- the Raiders finished a lowly 4-12. Like I said, they were terrible. But in the same way that REVISIONIST HISTORY has become the new norm in politics, so it has in medical research as well.
Although I have spoken of all of the research community's tricks-of-the-trade at various times in my EVIDENCE-BASED MEDICINE column; commenting on Dr. Keller's article was too good to pass up. Today you're going to see that TOM BRADY really does have nothing on Derek Carr!
"The Raiders can quickly and easily turn their season around by using the tried-and-true techniques of medical research. If a pharmaceutical company did 16 clinical trials of their new potential blockbuster, Drug X, they would never let a 4-12 outcome get them down. When published, I guarantee those trial results would look a lot better than 4-12. The Oakland Raiders can use the same techniques to improve their season record."
Of course Keller mentioned INVISIBLE & ABANDONED studies, which I have dealt with extensively on my site. This is the ultra-common practice (50% of all medical studies) of simply not finishing or not publishing research that's not conducive to selling your company's products to the public. He also talked about changing primary endpoints midstream. Changing your study's primary endpoint is roughly the equivalent of throwing darts at a dart board, missing the target every time, and then taking the dart board off the wall and painting an extra-large target of your own to make it appear like you are ready for the English Pub-League Championships.
"The Raiders lost 12 games in the 2018 season using the primary outcome of final score. But if we look closely at each of these 12 games, we might be able to find, by chance, another potential outcome we could switch to. Take, for example, when Oakland played the Indianapolis Colts on October 28th. The Raiders lost that game 42-28. But if we were to switch the outcome to the score at the end of three quarters, the Raiders win 28-21! We'll publish that as a victory without saying that we changed the primary outcome. Similarly, in their second game of the season, the Raiders lost to the Denver Broncos 28-20. But if we change the outcome to the score at halftime, we can publish this as a win, 12-0! We can do the same thing for their first game against the Los Angeles Rams."
A similar trick is using composite endpoints. Instead of limiting your study to one premise or hypothesis, you could have dozens (although you would never mention this in the final draft). The result is that if you throw enough darts, you will probably hit upon something. Especially if I add a little twist. If I have 25 dartboards on my wall instead of just one, I can throw my darts and pick the board(s) that the most land on, later claiming that my results were targeted and significant. Using similar tricks, the Raiders would have beat the Patrick Mahome's-led Chiefs --- twice.
"Take, for example, the third game of the season against the Miami Dolphins. Oakland lost that game 28-20, but Oakland had more total yards, more first downs, and a longer time of possession than Miami. Clearly, we can publish this as a victory for Oakland using our composite endpoints. Applying our composite endpoints, we can similarly change five other losses to victories. Oakland's record now is 13-3."
Next is a little trick that is exactly the opposite of the invisible and abandoned studies mentioned earlier --- publish your team's positive findings multiple times in multiple ways. With so many journals, and so many of these many journals desperately vying for what amounts to "breaking news," make sure that the data for each individual (positive) endpoint or hypothesis is published as it's own stand-alone study. Even better if you can mix it up a bit and publish the same findings in a different journal.
"Let's apply this principle to the Oakland Raiders. Their most impressive victory of the entire season was when they upset a very good Pittsburgh Steelers team -- on the road, no less -- on December 9th. We certainly want to publish that twice! Let's also duplicate-publish the Raiders' victories over the Denver Broncos and the Cleveland Browns. The Oakland Raiders' final record after applying the principles of medical research is an undefeated 16-0."
Lest you think that this is an over-hyped absurdity, simply spend some time skimming through titles of my EBM column (see earlier link) and realize that in many cases ---- particularly cases where there is a lot of money at stake ---- this is a perfect description of a few of the ways you are being swindled. Even JOHN Q AVERAGE DOCTOR knows this (Keller is an ER doc with 25 years of experience who works in prisons).
It all goes to prove what I have been telling patients for nearly three decades --- your health is up to you. HERE is a post that might provide some ideas for starting the process of taking your health back. And if you appreciate what you are seeing on our site, be sure and like, share, or follow on FACEBOOK as it's still a good way to reach the people you love and value most.
BRAIN INFECTIONS IMPLICATED IN NUMEROUS DISEASE PROCESSES
"Multiple sclerosis is a serious chronic neurological disorder in which demyelination and inflammation occur in the white matter of the central nervous system. The most likely cause is a virus because more than 90% of patients with MS have high concentrations of IgG in the brain and cerebrospinal fluid. Most chronic inflammatory central nervous system disorders are infectious." Cherry-picked from the March 2005 issue of Lancet Neurology (Infectious Causes of Multiple Sclerosis)
"Multiple sclerosis is a chronic neuroinflammatory disease that is characterized by progressive, inflammatory, and multifocal demyelination of the brain and spinal cord. MS affects approximately 2.5 million people worldwide, with women being afflicted twice as frequently as men. Importantly, young adults are the primary groups afflicted with MS: the average age of diseases onset is 30 years, with half of these patients requiring a wheelchair within 25 years of their diagnosis. Currently, there are three prevalent theories on the pathogenic mechanisms for MS: autoimmune, degenerative, and infectious. These pathogenic mechanisms are not mutually exclusive." From the October 2016 issue of the Journal of Neurology and Neurophysiology (A Review of Multiple Sclerosis as an Infectious Syndrome)
I want to start by addressing something that everyone is already thinking --- just vaccinate people so they don't become infected. No infection, no disease --- right? While vaccines MIGHT prevent overt diseases (emphasis on the word 'might'), because they contain germs, germ parts or germ proteins; thanks to MOLECULAR MIMICRY, one's immune system can begin attacking self if it perceives that the germ-based proteins it's been attacking has a close enough molecular shape to myelin or other human proteins or structures (it's similar to the concept of GLUTEN CROSS-REACTIVITY). This would help explain why even though the number of vaccines has increased exponentially over the past several decades (HERE), we are seeing more autoimmunity than at any time in human history (HERE or HERE).
"The immune siege appears to be a result of something called "molecular mimicry." Normally the body's immune system attacks foreign invaders like viruses and bacteria. If a molecule that's part of the body happens to closely resemble a portion of an intruding microbe, then both molecules can be targeted. Put another way, say a particular protein on the surface of a virus is similar in structure to a protein found in myelin. The immune system ramps up to clear the virus but also attacks the myelin. It's a case of mistaken identity, of collateral damage. The idea of molecular mimicry is one of the most important ones in MS. We and others have shown that mimicry between myelin peptides and viral and bacterial peptides indeed exists."
Here's what's even crazier. When quizzed about which germ was believed to be the culprit, just as you saw in the links provided in the first paragraph, the answer was that it could be just about any of them. In other words, there are large numbers of germs, antigens and other "factors" that can lead to autoimmunity. I've actually spoken of some of those 'factors' HERE. And when asked about what the scientific community is doing to address this, the answer was that rather than relying on the IMMUNO-SUPPRESSING drugs which are almost universally used today, a new form of treatment (immuno-tolerance therapy) is supposed to REDUCE IMMUNE SYSTEM ACTIVITY by acting as (and I quote) "a sort of negative vaccine." A negative vaccine? Huh?
In light of everything we've discussedin this post, coupled with THESE POSTS (not to mention THIS POST), we can't be surprised that constantly amping up immune systems --- especially young and immature immune systems --- with large and constantly-increasing numbers of shots has led to HUGE CONTROVERSY concerning what sorts of SIDE EFFECTS we may be heaping on future generations. If you appreciate what you are finding on our site, be sure to like, share or follow on FACEBOOK. And if you are looking for ways to control systemic inflammation (the root of most chronic illnesses and chronic pain), THIS FREE MOSTLY-DIY POST might provide you with a few ideas.
VIRAL INFECTIONS AND THEIR
RELATIONSHIP TO CHRONIC ILLNESS
"As far back as 1385, doctors in Europe recorded connections between influenza infection and psychosis. That link between the flu and the brain became much more apparent during and after the 1918 Spanish flu epidemic. More direct evidence for the virus-brain link came in the 1970s, when researchers found viral antigens in the brains of deceased people who had been afflicted with a condition known as encephalitis lethargica. One of the earliest links between influenza and neural dysfunction was a correlation between the 1918 Spanish flu, caused by a subtype called H1N1, and an epidemic of Parkinson’s a few decades later. In the 1940s and early 1950s, diagnoses of the neurodegenerative disease appeared to increase abruptly, from 1–2 percent of the US population to 2.5–3 percent, then fell back down to 1–2 percent. 'Basically, 50 percent more people in those years got Parkinson’s.'"
The authors spoke of two different mechanisms whereby this happens. The first involves something we have discussed many times previously; a disruption of the blood-brain barrier. Metabolically and physiologically this is quite similar to what happens in leaky gut syndrome, which is probably why it has a similar name ---- LEAKY BRAIN SYNDROME. The second had to do with an "over-activation" of a type of neurological / immune system cell known as GLIAL CELLS. The end result? "Two different flus, two different mechanisms, but the same effect in a sense. They were both inducing inflammation and death in the parts of the brain that degenerate in Parkinson’s disease." What's doubly interesting is how GUT HEALTH came into play.
The authors went on to talk about a "widely accepted hypothesis" that's been around for nearly two decades. "Parkinson’s disease starts in the gut, manifesting as digestive issues, and then moves into the brain. The progression of the disease from the gut to the forebrain, that takes place over maybe 25 or 30 years in a human." From there the discussion moved on to several other chronic neurological diseases that have can have roots in chronic infections. MULTIPLE SCLEROSIS, more on PARKINSON'S, and HIV. If you follow my site you already know how common this phenomenon really is (HERE).
What's their recommended solution? You already know the answer. "Vaccination for the flu—or at the very least, taking Tamiflu if a person gets infected—might help prevent neurological complications of influenza infection." Key word here is 'might'. What other issues 'might' their approach lead to? Unfortunately, numerous studies have shown that not only do consecutive years of flu vax make it increasingly ineffective at preventing flu (HERE), but that those same consecutive years of shots can actually lead to significantly increased chances of developing Alzheimer's (HERE). And as for Tamiflu; if there's been a bigger hoax perpetrated on the American people through the concerted efforts of big pharma and the medical community (HERE), I'm not sure what it might be other than possibly STATIN DRUGS.
Although it's impossible to cut your risk of chronic disease to zero; because this short article mentioned the word INFLAMMATION nine times, it would behoove us all to both understand what it really is, and have a plan for diminishing it systemically. My plan is free of charge (HERE), and is in no ways to be considered a "cure" for neurodegenerative diseases. But as far as helping reduce the factor that seems to be the common denominator in virtually all health problems (inflammation) it's a start. Fortunately there are doctors out there (Karim Dhani in Toronto is one of them) who specialize in tracking down and helping chronically ill people with occult infections. Oh, and if you like what you are seeing on our site, be sure to like, share, or follow on FACEBOOK.
GUT BUGS ARE CRITICAL FOR OVERALL HEALTH & AUTOIMMUNITY PREVENTION
(BUT DON'T FORGET THE VITAMIN D!)
As long as there is balance in the microbiome, the immune system idles softly, ready for immediate response if called upon. However, when there is a disruption in gross numbers or ratios of these organisms (DYSBIOSIS), the end result is sickness and disease of numerous kinds --- diseases that are linked in more ways than the average doctor realizes or typically cares to understand (HERE). When AUTOIMMUNE DISEASES RESULT (click for a list of some of the more common ones), it's critical to realize that most of these have nothing overtly to do with the gut. In other words, the self-immune system attack and subsequent symptoms can occur anywhere, which is why, regardless of symptoms, natural healers have been preaching "heal the gut, heal the body" since well before THE ADVENT OF MODERN MEDICINE. Today we will look at a few brand new studies that spell this out.
Next month's issue of Current Opinions in Rheumatology (The Microbiome in Systemic Autoimmune Disease: Mechanistic Insights From Recent Studies) tells us exactly why this is happening. "Recent changes in modern societies have disrupted homeostasis and contributed to a rise in immune-mediated conditions." First, to call what's going on a 'rise' is like me calling the Grand Canyon a ditch (HERE). The truth is, thanks to modern, Westernized lifestyles, we have been facing an EXPLODING INCIDENCE OF AUTOIMMUNITY for decades. Secondly, we see today's first mention of compromised epithelial barriers ('THE LEAKIES'). "Recent studies highlight that a breach of the gut barrier and translocation of commensal bacteria to non-gut organs can trigger several autoimmune pathways that can be prevented by commensal vaccination or dietary interventions."
While it's quite true that vaccinations can cause autoimmunity via the dysbiosis pathway (HERE), this is not the sort of "vaccination" these authors are speaking of. They are talking about "vaccinating" (their word, not mine) using entities such as PROBIOTICS, FECAL MICROBIOTA TRANSPLANTS, VAGINAL SWABBING (SEEDING) for babies born via C-section, or maybe even plain old GARDENING OR HAVING AN INDOOR / OUTDOOR PET. It could be as simple as feeding your microbiota with plenty of NON-DIGESTIBLE FIBER. The object is to get people exposed to diverse microorganisms, and lots of them, while feeding them what they need to colonize the Gut. As the authors reveal, this diminishes inflammation and helps shore up the "leaks" that allow these organisms into the general circulation. Let's move on to another concept that is starting to gain traction in the current research on GUT HEALTH --- molecular mimicry as a cause of autoimmunity (as seen in the same study).
"Recent findings suggest that autoimmune manifestations in genetically susceptible individuals can arise through cross-reactivity with commensal orthologs of autoantigens or commensal-mediated posttranslational modification of autoantigens. Physiologic responses to gut, oral, or skin commensal bacteria can thus be misdirected toward such autoantigens in susceptible hosts."
Two things to talk about here. First is that in most cases, the majority of those who are "genetically susceptible" do not get sick. Why not? Because as I've shown you HERE and HERE, epigenetic factors (bad habits and exposure to bad things like THIRD-HAND SMOKE, TOXIC CHEMICALS, SUGAR, or XENOESTROGENS) are, at least in the vast majority of cases, much more important than raw genetics and whether or not you carry a particular gene. This is why I have said repeatedly that you are not controlled by your genes nearly as much as you have been led to believe (HERE). Secondly, in many ways this phenomenon is similar to GLUTEN CROSS-REACTIVITY.
Because there are many foods with proteins that have a similar molecular structure to GLUTEN (wheat protein), in certain individuals, these proteins can trigger serious gluten sensitivity-like reactions (EVEN IN NON-CELIACS). The highlighted paragraphs simply show that some "commensal organisms" (bacteria, fungi, etc that we live with every day) are "orthologs of autoantigens". This is a fancy way of saying that some of these microorganisms contain or secrete compounds with a similar enough molecular architecture to a tissue, enzyme, or protein in your own body that given the right conditions, your immune system may actually start attacking said tissue, enzyme or protein in the case of autoimmunity.
We just saw an example of this in a study on a common autoimmune issue, ECZEMA, that was published earlier this week in Science Translational Medicine (The Nonlesional Skin Surface Distinguishes Atopic Dermatitis with Food Allergy as a Unique Endotype). Bottom line, while it's always possible for the immune system to go haywire without any outside help, these sorts of dysfunctions are mostly related to epigenetic issues --- issues that if understood, can be somewhat controlled or at least managed.
Now, back to the leakies. Last month's issue of the International Journal of Molecular Sciences (Recent Advances on Microbiota Involvement in the Pathogenesis of Autoimmunity) had this to say about LEAKY GUT SYNDROME (which in the scientific medical community is known as increased intestinal permeability or similar).....
"The impact of an imbalanced gut microbiome in the pathogenesis of autoimmunity has been suggested by an increasing amount of experimental evidence, both in animal models and humans. Several physiological mechanisms, including the establishment of immune homeostasis, are influenced by commensal microbiota in the gut. An altered microbiota composition produces effects in the gut immune system, including defective tolerance to food antigens, intestinal inflammation, and enhanced gut permeability. In particular, early findings reported differences in the intestinal microbiome of subjects affected by several autoimmune conditions, including prediabetes or overt disease compared to healthy individuals."
Not only do we see "enhanced gut permeability" here, which allows an array of particles to get into places they shouldn't, we see the authors talking about both "food antigens and intestinal inflammation". Let's see how these work in concert with a leaky Gut to cause autoimmunity. If you are consuming foods that your body is sensitive to, whatever those might be and for any number of reasons (GRAINS, DAIRY, NIGHTSHADES, LECTINS, etc, etc) your body will react by creating INFLAMMATION. This inflammation causes the cellular 'tight junctions' that separate the contents of your intestines from your blood stream to actually get bigger (looser). The end result is that particles of undigested food, PARASITES, toxins and other "stuff" are allowed to leak through, winding up in systemic circulation, where the body mounts increasingly intense immune system responses against them. What's interesting is that for nearly a century, science has shown that once the immune system starts attacking gluten, it's much more prone to start attacking self --- it's own cells, tissues, enzymes, proteins, etc (HERE) via autoimmune reactions.
Just so you are aware, the importance of GUT HEALTH encompasses both autoimmunity and a wide array of inflammatory diseases (see earlier link on inflammation) as seen in this three month old issue of Clinical Science (Impact of the Gut Microbiome in Cardiovascular and Autoimmune Diseases).
"The gut microbiome functions like an endocrine organ, generating enzymes and bioactive metabolites, which affect host physiology. Alterations in intestinal microbial and metabolic composition play an important role in human health and disease, including cardiovascular and autoimmune diseases. Changes in the composition of gut microbiota (dysbiosis) are linked to chronic inflammation, thrombosis, atherogenesis, chronic kidney disease, obesity, and type 2 diabetes. Moreover, significant evidence exists to implicate the role of microbiota in blood pressure regulation and heart failure. Microbiota interacts with the host through multiple pathways....."
The GUT BACTERIA AS AN ENDOCRINE ORGAN? Of course! It's why none of this should be shocking if you understand some of the larger "pathways" indicated in the last sentence. For instance, we've known for a long time (HERE) that cardiovascular disease is not so much caused by consuming fat (HERE) as it is caused by consuming sugar and high glycemic processed carbs. I would take that a step further, saying that virtually every modern health problem has roots in BLOOD SUGAR DYSREGULATION. And the cherry on the sundae is that sugar feeds infection, dysbiosis included (HERE). This is why I have written so many articles on doing whatever it takes to BREAK YOUR SUGAR ADDICTION.
Now that we've established that your microbiome is critical for your health, the most important question to ascertain is what you might be doing to foul it. Although most drugs have anti-microbial properties (HERE), the one class of drug that will absolutely throw your microbiome into dissaray is ANTIBIOTICS. Nothing, and I mean nothing screws people up faster, longer, and often times earlier in life than antibiotics (the most dangerous offender of being the family of antibiotics known as FLUOROQUINOLONES such as cipro). THIS ARTICLE shows the numerous ways in which antibiotics are screwing up people's health. A brand new study, takes it a step further, showing that prescribing babies antibiotics messes up their brains. From last month's issue of Science Reports (Oral Neonatal Antibiotic Treatment Perturbs Gut Microbiota and Aggravates Central Nervous System Autoimmunity).....
"Gut microbiota dysbiosis has been considered the essential element in the pathogenesis of multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis (EAE). Antibiotics were administered orally to Dark Agouti (DA) rats early in their life with the aim of perturbing gut microbiota and investigating the effects of such intervention on the course of EAE. As a result, the diversity of the gut microbiota was reduced under the influence of antibiotics. Consequently, aggravation of EAE, paralleled with stronger immune response in lymph nodes draining the site of immunization, and increased inflammation within the CNS, were observed in antibiotic-treated DA rats. Thus, the alteration of gut microbiota leads to an escalation of CNS-directed autoimmunity in DA rats. The results of this study indicate that antibiotic use in early life may have subsequent unfavourable effects on the regulation of the immune system."
The last link above proves that while this might be scary, it cannot in any ways be considered new information. How scared should you be as a parent or grandparent of young children if you are taking them to the doctor for antibiotics for anything less than life-threatening situations?
"There is an increasing awareness of serious consequences of antibiotic use on gut microbiota. Indeed, a rising number of observational, clinical, and epidemiologic studies focused on children and antibiotics use show that antibiotic exposure-related dysbiosis of intestinal microbiota increases the risks for various diseases such as obesity, diabetes, inflammatory bowel diseases, celiac disease, allergies and asthma. Antibiotics are the most commonly prescribed pediatric drugs, taking a share of more than 30% of all drugs prescribed to children younger than two years."
If this doesn't wake you up, this next study might. Thanks in part to antibiotics, "rare" diseases are becoming increasingly less rare. January's issue of the Journal of Autoimmunity (The Microbiome and Immunodeficiencies: Lessons From Rare Diseases) described a few of the pathways whereby this increase in previously rare disease is occurring. The study started by describing PID's (Primary Immune Deficiencies) as "inherited disorders," leaving those individuals more prone to "malignancy, inflammation and autoimmunity".
Next, the authors suggested that a DIMINISHED HOMEOSTASIS of the gut bacteria (dysbiosis) leads to "altered intestinal permeability and bacterial translocation". In other words, bacteria and their metabolites gain access to the systemic circulation, where the immune system either attacks these bugs outright or via the 'molecular mimicry' pathways we spoke of earlier. This leads to "immune system dysregulation," which results in "enhanced pathobionts colonization" (can anyone say BIOFILMS?), "increased disease susceptibility and secondary infections in these patients".
Here's where things really start to get dicey. Not only do the factors discussed by the authors (increased inflammation, increased autoimmunity, increased malignancy) occur directly, they can occur indirectly as well. We are seeing this in the numbers of studies relating chronic latent infections to these sorts of problems. Although I spoke of this relationship recently in a post linking still another infection to Alzheimer's (HERE), in my post titled SECOND THOUGHTS ON THE GERM THEORY, I wrote......
"Despite our best efforts to "cure" infectious disease, why are rapidly growing numbers of people plagued with illnesses that are increasingly believed to be the result of what Dubos referred to as "latent infections" (ALZHEIMER'S DISEASE, DISC HERNIATIONS, EBV, PANDAS/PANS, IBS, FLACCID PARALYSIS, DISEASES FROM ROOT CANALS OR OTHER ORAL INFECTIONS, and on and on and on)?"
More importantly, how do these authors --- MD / Ph.D research types from prestigious institutions and universities in both Italy and the United States --- propose we solve this issue? Pay close attention. "Finally, we provide evidence, in preclinical models of PIDs, for the efficacy of microbiota manipulation to ameliorate disease complications, and suggest that the potential use of dietary intervention to correct dysbiotic flora in PID patients may hold promise." There are essentially four ways to deal with underlying dysbiosis, with doctors (especially doctors with a 'natural' bent) trying them in various combinations.
- You can try to kill the dysbiosis off with either natural or chemical antibiotics (which often means you kill everything and have to start completely over or almost so from scratch).
- You can do FMT, which is quite amazing and effective if YOU CAN FIND THE RIGHT DONOR (it's all about your donor).
- You can take prebiotics, probiotics, and various bacterial metabolites marketed as nutritional supplements (the problem is, at least with probiotics, they don't do a very good job of matching your gut's natural microbiome --- HERE).
- You can change your diet, because there is abundant evidence that what you feed your "Gut Bugs" is either driving or squelching your health (i.e., antibiotics usually precipitate dybiosis, but sugar and high glycemic carbs feed it). See earlier link on fiber.
How can information like this help you solve your chronic health issues? For starters, simply by better understand and deciphering the current scientific literature. For instance, the issue of Autoimmune Reviews that came out about six weeks ago published a study titled Autoimmunity in Celiac Disease: Extra-Intestinal Manifestations that dealt with all the "extra-intestinal" (non-gut) ways that CD can affect people (something I've shown you previously in my posts on gluten's association to neurological disease --- HERE, HERE or HERE). Here are the mechanisms, exactly as we have previously discussed today....
"Nutrients, dysbiosis, dysbiotic components and their mobilome, post-translational modification of naive proteins, inter-enterocyte's tight junction dysfunction resulting in a leaky gut, microbial lateral genetic transfer of virulent genes, the sensing network of the enteric nervous systems and the ensuing pro-inflammatory messengers are mutually orchestrating the autoimmune interplay. Genetic-environmental-luminal events-mucosal changes are driving centrifugally the remote organs autoimmunity, establishing extra-intestinal multi organ injury."
Super technical sounding, but what is this really saying? That certain nutrients (gluten, for instance, is a protein) can team up with dysbiosis and the molecular byproducts created by these 'bad' organisms, causing the tight junctions to become loose or leaky, which can lead to bacteria transferring "virulent genes" to their buddies. The result is an "interplay" (a vicious cycle that can feed itself while spinning either direction) between inflammation and autoimmunity. Once the necessary factors are in play to actually turn these 'bad' genes on (the very definition of epigenetics), the problems they cause are not constrained to the Gut, but can travel to the farthest (remotest) reaches of the body, leading to even more "autoimmunity and multi-organ injury".
Although we could play "pick a disease, any disease" and watch this phenomenon in action, let's take a look at arthritis. In December's issue of Arthritis and Rheumatology (Microbiome Analytics of the Gut Microbiota in Juvenile Idiopathic Arthritis Patients...) we see something that we already knew or at least suspected; that the guts of children with inflammatory autoimmune arthritis are different than the guts of children without. "We found evidence for dysbiosis in JIA patients." Why is this important to both know and understand? The same month's issue of Cell Immunology revealed via its title (Modulation of Autoimmune Arthritis by Environmental 'Hygiene' and Commensal Microbiota) that there are steps that people can be taking to help themselves, without relying on DANGEROUS DRUGS for everything.
"Specific commensal organisms are associated with enhanced severity of arthritis in susceptible individuals, while exposure to certain microbes or helminths can afford protection against this disease. In addition, the role of metabolites (e.g., short-chain fatty acids, tryptophan catabolites), produced either by the microbes themselves or from their action on dietary products, in modulation of arthritis is increasingly being realized. In this context, re-setting of the microbial dysbiosis in RA using prebiotics, probiotics, or fecal microbial transplant is emerging as a promising approach for the prevention and treatment of arthritis."
Interesting because this is exactly what I was talking about in my earlier bullet points (although I fialed to mention the part about purposefully creating HELMINTH INFESTATIONS). It's all about the HYGIENE HYPOTHESIS folks. And although VITAMIN D is mentioned in my GENERIC AUTOIMMUNE PROTOCOL (not to mention several of these studies), let's take a bit deeper look at why it's doubly critical to understand for those of you with AUTOIMMUNITY. Just remember as you read this next (short) section that the reason that Vitamin D gets so much publicity in relation to other vitamins is because it's not really a vitamin at all, but an immuno-modulating hormone precursor.
GUT HEALTH, AUTOIMMUNITY AND
THE CONNECTION TO VITAMIN D
Under a header titled Vitamin D and the Innate Immune System: Antimicrobial Activity, we start to learn how necessary Vitamin D really is if you want to stay healthy. We'll get there, but first let's talk about the innate immune response (as opposed to acquired immunity). The innate response pertains to the aspects of immunity that you are born with, namely white blood cell function (except for lymphocytes) and inflammation as well as the cellular barriers that I already showed can become "leaky". Also under innate immunity you'll find numerous types of enzymes and other proteins that have varying degrees of antimicrobial properties. Acquired immunity pertains mostly to the antigen / antibody reactions, which we will cover momentarily.
Citing studies from the 1940's, the authors wrote that "Vitamin D is a well-known regulator of innate immunity.... D3 increases chemotaxis, autophagy, and phagolysosomal fusion of innate immune cells.... and up-regulates CAMP in cells participating in the innate immune system as first-barrier defenses" In essence this means that with Vitamin D the body can get the proper cells or metabolites to where they need to go quicker (chemotaxis), that the body is better adapted to a form of detoxification that involves deconstructing and recycling old and worn out cells in an orderly fashion (autophagy), that the cells that engulf and dissolve harmful invaders in "BLOB-LIKE" fashion are working at full capacity (phagocytosis / phagolysosomal fusion), as well as aiding in cellular signaling / messaging (up-regulating cyclic AMP). What did the authors conclude after looking at these factors in detail?
"Taken together these data point to a role of vitamin D in defending the organism against pathogens, suggesting that vitamin D sufficiency has to be granted in patients affected by acute or chronic infection."
In other words, if a person is dealing with an infection (overt, occult as we spoke of above, or some form of dysbiosis), decades worth of studies mean it's a given that Vitamin D levels will be compromised / depleted. What this really means is that if you have an infection (dysbiosis included), there is an entire cascade of harmful effects to the immune system that will follow. The authors discussed why "THE LEAKIES" (hyperpermeable epithelial barrier membranes) are a factor in Vitamin D deficiency as well.
"Vitamin D is responsible for the barrier function of the intestinal epithelium and for the modulation of the bowel immune system, hence, low levels may be associated with greater gut permeability and, consequently, with Gut-induced metabolic endotoxemia that induces a low-grade inflammation. Moreover, vitamin D administration may influence Gut composition. In animals with vitamin D depletion and the knockout of the Vitamin D Receptors, Gut dysbiosis favors metabolic disorders. Other studies in mice demonstrated that Vitamin D Receptor [dysfunction] reduces the response to infection of the intestinal epithelium."
Metabolic endotoxemia implies that lipopolysaccharides (LPS) is present in the blood stream or organ that these epithelial barriers are trying to protect (lungs, brain, spinal cord, nerves, etc). LPS are byproducts of certain kinds of bacteria and are not only heavily associated with low grade inflammation, but with the sort of immune system hyper-reactivity that can lead the body to start attacking itself (although they are also associated with T2D, LOW T (or HIGH T), high levels of IL-6 and TNFA, DEPRESSION, FATTY LIVER, PARKINSON'S, OBESITY, and for those who regularly follow my site, CHRONIC PAIN).
The authors went on to mention Vitamin D's relationship to something I've already touched on, cellular apoptosis. "Over-expression of VDR in the intestinal epithelium induces resistance to colitis and decreases mucosal inflammation suppressing epithelial cell apoptosis, boosting tight junction function." In other words, having lots of (an "over-expression of") receptors for Vitamin D suppresses epithelial apoptosis. Activated by the TH-17 part of the immune system mentioned earlier, apoptosis is cellular death that is programed to occur when one of several things happen. Of course AGE can be a factor, and so can STRESS (metabolic stress, physical stress, psychological stress, etc).
Another factor, kind of like falling dominoes, is the fact that if I'm a cell and the cell next me undergoes apoptosis, I'm very likely to undergo apoptosis as well. Not to freak you out, but the average adult loses 50 to 70 billion cells a day to apoptosis, while children lose about half that many. Thus, it's easy to see why slowing this process down by addressing the factors that speed it up (vitamin D deficiency being one of many) could have some very beneficial results. Furthermore, research that was published just last week shows that making the correct changes to the cellular environment can slow down and in some cases, actually REVERSE cellular apoptosis.
Adaptive / acquired immunity is the opposite of innate immunity and deals with a type of white blood cell (lymphocytes) that will differentiate into either T-cells or B-cells (to see the difference, you can read THIS POST on the relationship between overactive immune systems and autoimmunity) or Natural Killer cells.
"D3 suppresses adaptive immunity. In experimental models it down-regulates the immune responses mediated by T helper (Th) 1 cells, thus inhibiting the production of pro-inflammatory cytokines, such as Interferon-y, IFN-y, IL-6, IL-2, and TNFA....... It has been suggested that Vitamin D3 acts as an immunomodulatory not only by suppressing Th1 cells activation, but also modulating Th2 cells, T regulatory (Tregs) cells activity, and Th17 cells."
We just discussed the TH-17 system, but TREGS are interesting because you want them activated in cases of autoimmunity. Why? They slow down or "regulate" an immune system that's galloping out of control.
After suggesting that there is strong data for the role of Vitamin D's ability to act as a modulator of the immune system to better fight pathogens, the authors revealed that there are no medical recommendations for Vitamin D supplementation in those specifically coping with autoimmune issues --- issues that by official counts affect almost 25 million Americans. Once, however, you start factoring in the dozens (maybe hundreds) of diseases that are believed to be autoimmune but not proven because the specific auto-antigen ---- the entity that's being attacked --- has yet to be discovered), many experts put this number at at least double or even triple this. Not surprisingly and for many reasons that are no fault of their own, the author's Vitamin D "recommendations" fall short.
"Thanks to the evidences of immunomodulatory effect of vitamin D the role of vitamin D deficiency and supplementation in autoimmune diseases has long been studied. Animal studies showed an important role of D3 supplementation in the control of autoimmune diseases...." [However], "There is no current indication for vitamin D3 supplementation in patients with infections and/or autoimmune diseases."
What we can do is read between the lines a bit. Even though, depending on one's age (older people are supposed to take a higher dose), the RDA for Vitamin D ranges from 400 to 800 international units (IU) per day, every FUNCTIONAL MEDICINE expert I know (including many who are MD's) laughs at this. While I am not going to make any recommendations of my own, suffice it to say that the authors of this study talked about certain conditions and studies where the participants received as much as 50,000 IU a week, or (gulp) 300,000 IU in a one-time "bolus". One of the more brilliant functional medicine MD's I know has told me that for certain patients in certain situations, he sometimes recommends as much as 80,000 IU's a day, short term (do not do any of this without first consulting your physician).
If you are interested in seeing some more information on Vitamin D as it pertains to natural light (HERE and HERE) or how it plays a part in my generic health protocol (HERE), as well as what the profile of the average autoimmune sufferer tends to look like (HERE), just follow the links. And as always, if you like what you are seeing, be sure and like, share, or follow on FACEBOOK as it's still a great way to reach the people you love and care about most.
CHRONIC PAIN RELIEF
UPPER BACK AND NECK
Probably due to the physical demands of LOGGING, Anthony had developed FASCIAL ADHESIONS that had literally "TETHERED" the musculature on the right side of his spine from the top part of his THORACOLUMBAR FASCIA clear into his NECK. I quickly figured out what was going on, broke the adhesions, adjusted him, and did not see him again for three years. In fact, this has been his pattern.
I've seen him once every three years since that time, with the latest coming sometime last week. Although I had forgotten how severe this problem was for Anthony when I first saw him, he reminded me. When I asked if he would be interested in sharing his story via a video, he agreed. And while it's short and to the point, it's quite clear not only how severe he was, but how much the care in our office changed his life.
MINNESOTA CHRONIC PAIN RELIEF
IN MOUNTAIN VIEW, MISSOURI
There was no rhyme or reason for Tedd's pain. He simply woke up with it one morning and has been struggling for two and a half decades --- all while continuing to work a physically demanding job. What has he done to try and solve this problem? He tried all the usual; CHIROPRACTIC ADJUSTMENTS, THERAPY, massage, ACUPUNCTURE, INJECTIONS, and even SURGERY. And that's just for starters (the list he gave me is to long to print here, but those of you who have been down the same road could guess most of it).
And of course he had had every imaging test under the sun (HERE, HERE and HERE), all to no avail, with everyone seemingly trying to explain his pain away with brilliant diagnostic statements like "Gee Tedd, you just aren't as young as you used to be" --- unfortunate and ridiculous for a person significantly younger than I AM. When I hear a history like his --- the only thing that brings any real relief is chiropractic adjustments, but they just don't hold (LIKE THIS) --- my first thought is always SCAR TISSUE / FIBROSIS. Rather than me talk about it, I am going to let Tedd spill the beans in an unsolicited email I received yesterday.
Good Morning Russell,
I just wanted to send you quick note on my progress. It was three weeks ago yesterday that I had my first treatment done in your office. I have been following the guidelines on the stretching and implemented the exercises that we discussed. The days after the treatment it’s almost like I had a flare up and my symptoms worsened.
Since then things have vastly improved. Before the treatment I had been seeing a chiropractor on average twice a week for over 20 years. I can happily (ecstatically) say that I haven’t felt the need to get adjusted since leaving your office. My mobility has improved along with a massive reduction in pain. In one treatment my back and neck went from weak and fragile to strong and durable.
Thank you so much for treating me! I almost forgot to tell you I shoveled approximately 6,000 pounds of snow off my roof yesterday. I couldn’t even do one shovel full a month ago.
All I can say Tedd is fantastic! I never get tired of hearing stories like these. Ever! And let's all be honest with each other for a moment; who else tells their patients that they will know after a single treatment if their treatment will prove helpful (HERE, HERE or HERE)? By the way Tedd, if you and your wife are ever in Missouri when the weather is good, hit me up and we'll head to CURRENT RIVER and continue the great conversations we had during our two hours together! For my readers, especially those struggling with chronic conditions, be sure and check out THIS POST. And if you appreciate what you are finding on our site, be sure and spread the wealth by liking, sharing, or following on FACEBOOK.
FLORIDA CHRONIC PAIN RELIEF
IN MOUNTAIN VIEW, MISSOURI
It wasn't, however, that Lynda hadn't tried other things first. She had tried CHIROPRACTIC, THERAPY, massage, etc, etc, etc, as well as going through the usually battery of imaging tests --- tests which I have shown many times previously do not often do what people are led to believe they do (HERE, HERE, and HERE). The funny thing is, her drive to see me was no problem since sitting does not cause any pain. Here is the email I received last evening after seeing her one week ago this morning (6:30 am).
Every time I go to your website I learn so much more. Your site is amazing and huge!! I recently quit Atoravastin just in case that might be contributing to my issues. I am so much improved and now feel that I can begin to understand my pain. Thank you so much! I will have a full life as a result of my visit to see you. So worth the 17 hour drive.
Allow me to break down Lynda's case by first addressing her comment on Atoravastin (Lipitor). Probably the most well-known of the statin drugs; never forget that their chief side effect is musculoskeletal pain (not far behind are DEPRESSION and DEMENTIA). I'll not spend time belaboring the never-ending statin scam, but be sure to read some of my posts on the subject (HERE) as well as Dr. Angela Stanton's one week old article on my friend CHANDLER MARRS' website (Hormones Matter), titled STATINS, WHO NEEDS THEM? Bottom line, statins are one of the biggest deceptions ever perpetrated on the American public by big phama and their lackeys.
When I examined Lynda I noticed that she had serious loss of range of motion in her right hip, as well as right leg and buttock pain (unbearable when she stood for longer than a few minutes or walked, but not present at all when sitting or lying down). She also had a lot of pain and restriction in the region of her hip flexor. Although she believed she had PIRIFORMIS SYNDROME, people with PS cannot sit, spending their lives either standing or lying down.
Instead, Lynda's leg pain and hip / buttock pain was being caused by FASCIAL ADHESIONS of the buttock and HIP FLEXOR REGION. The buttock restrictions caused the ever-common entrapment of the SUPERIOR CLUNEAL NERVE (one of many CUTANEOUS NERVES with a penchant for becoming entangled in HAIRBALL-LIKE connective tissues that can become "TETHERED" due to combinations of traumatic, repetitive, or postural injuries). This tethering can also be caused by unbridled systemic inflammation, because INFLAMMATION ALWAYS RESULTS IN FIBROSIS --- the medical word for "SCAR TISSUE". For the record, I did not adjust Lynda.
It was a 17 hour drive for a one hour figure-it-out-as-we-go treatment. You saw the results. Of course I would never hope to tell you that every person I treat gets such results, but let me ask you this...... Who else tells their patients that they will know in a single visit whether or not my unique approach to CHRONIC PAIN will help them? One visit! I don't know of anyone. And if you look at my TESTIMONIALS (or HERE), you'll see that it's not an uncommon phenomenon in my clinic.
As always, I suggest people do what they can to limit the amount of inflammation they are exposed to on a daily basis (HERE). While you're at it, help us spread the wealth. If you appreciate what you are finding on our site, be sure and like, share, or follow on FACEBOOK as it's a good way to reach the people you love and value most!
NEW PAPER REVEALS THAT INTEGRITY IS LACKING IN BIOMEDICAL RESEARCH
After talking about the UNSUSTAINABLE TRAJECTORY of our current model of healthcare, the authors discussed how errors in biomedical research, whether accidental or intentional, affect hundreds of millions of people worldwide. Think about these staggering numbers for a moment. With this many people being affected, we are obviously talking about a lot of money --- easily billions of dollars. And with billions of dollars at stake, do you think that individual researchers, scientific institutions and universities, as well as the pharmaceutical industry itself that controls them all, are above intentionally affecting research to make it say what they want --- to make it whisper the 'sweet nothings' that will keep the money flowing? As I've shown you time and time again in my EVIDENCE-BASED MEDICINE column, sweet nothings are an all too common theme in the medical research field.
"While fractions of the population succumb to a specific disease that may need drug therapy, the entire human population eats food and is directly affected by nutrition research. Further, the science of nutrition is particularly contentious and territorial. A great irony of nutrition research is that most of it is conducted by healthcare professionals with little to no formal training in nutrition. Clinical therapeutic nutrition is not taught in the vast majority of medical schools nor in post-graduate medical training programs, including those specialties that are obviously impacted by dietary intake such as gastroenterology and cardiology. Despite this absence of training in clinical nutrition, the medical profession proclaims itself authoritative on all health-related topics, including the entire territory of clinical nutrition. A major and serious problem arises when unskilled and invalid research is published by authors (including nonphysician journalists) in major journals which mischaracterizes the validity of nutrition interventions (e.g., essentially always concluding that nutritional interventions are inefficacious or potentially hazardous) and then such research is used politically and in the media to disparage, restrict and regulate practitioners and nutrition supplement industry to the detriment of human health."
DOCTORS AND DIETARY RECOMMENDATIONS --- how many times have I shown you that their "GUIDELINES" cannot be trusted? In Dr. Vasquez's recent reviews of fish oil studies that were done by the ever-corrupt ACC / AHA, he uncovered the fact that they were using (gulp) mineral oil placebos against a patented form of "medical" fish oil to make their product look better, while using cardio-protective olive oil as the placebo to test against regular fish oil for the express purpose of making it look like there was no real difference between the experimental and control groups. In other words, according to their study, the patented fish oil is the only 'effective' fish oil.
Interestingly enough, this same phenomenon was recently exposed within the vaccine industry. You can read my version HERE or you can read Robert Kennedy Jr's version over at Collective Evolution (New study: Vaccine Manufacturers & FDA Regulators Caught Hiding Risks of HPV Vaccines). And here the thing folks; manipulating placebos is only one of hundreds of ways that studies are being finagled for industry (see earlier link on EBM).
By the way Dr. Vasquez's "Pharma Echo Chamber and Power Chamber" was priceless. It was a circular diagram showing how the media, research community, medical schools, and medical journals have been co-opted by BIG PHARMA to the point where this cartel has become as powerful as governments. Interesting because a few years ago I showed you a study proving that in many cases Big Pharma and Big Government are the same entity (HERE). If you want to better understand health in general, you will find some very cool videos on DR. V's YOUTUBE CHANNEL. He goes into serious detail concerning the reasons it's almost impossible to trust anything put out by Big Phama, including information and studies concerning vaccines (HERE).
And for those of you struggling with chronic illness or chronic pain, you may want to check out my MOSTLY DIY SOLVE-IT-YOURSELF POST as well. I fully realize that some of you will require a SPECIFIC FUNCTIONAL MEDICINE APPROACH, but for many of you reading this --- probably the vast majority --- the simple hints provided completely free of charge will help you get started on your journey back to health. If you enjoyed today's post, be sure and spread some love around FACEBOOK since it's still a great way to reach the people you love and value most.
CHRONIC, NON-SPECIFIC BACK PAIN...
COULD THERE BE A SOLUTION FOR YOU?
- MEDICINE IS INCREASINGLY BASED ON TESTING: It's inarguable that we've gotten away from TOUCHING PATIENTS or for the most part, even really examining them in any sort of meaningful way. For insurance companies to pay claims, there must be a "provable" diagnosis, with much of this "proof" coming in the form of imaging from CT, MRI, digital x-ray, etc, etc. There's a problem with this approach....
- TESTS DON'T SHOW WHAT DOCTORS ARE LEADING PATIENTS TO BELIEVE THEY ARE SHOWING: When it comes to these tests, almost nothing is as it seems --- or as patients are led to believe. There's the fact that degenerative changes seen in the spine don't correlate well to patient's symptoms (HERE). There's the fact that routine physical examinations are not catching simple orthopedic problems (i.e. diminished ranges of motion) prior to them becoming complicated and chronic (HERE). There's the fact that at least 50% of the pain-free population is walking around with visibly herniated discs in their spines (HERE). And in all honestly, this bullet barely scratches the surface of how bad things really are in the realm of testing and treatment (HERE).
The world's foremost leading expert on spinal discs and biomechanics, Dr Stuart McGill, says this on his website.......
"Back pain always has a cause. Most patients receive poor advice that remains a barrier to recovery. They stay in pain unnecessarily. Some receive pain-numbing medication that does not stop the cause of pain. Some are told that they must learn to live with the pain, rather than being shown why they have pain together with a roadmap of the steps to reduce it. The key to success is to understand the pain mechanism, and address the mechanism."
When looking at a lateral view of the spine, the first thing we notice is the curves. The (normal) forward curve in the neck and low back is known as "lordosis" or "lordotic," while the mid-back curve runs the opposite way and is known as "kyphotic" or "kyphosis". What do these curves do? For starters they allow normal movement, both segmentally and sectionally (HERE). Proper curves also create a spring-like function that allows the spine to act as a sort of shock absorber; particularly important if you work on CONCRETE or other hard surfaces.
Without proper curves your spine would take a pounding of epic proportions. The curves work to distribute weight and force as well as transferring muscle energy to where it's needed. As you might imagine from looking at the picture; when spinal mechanics are off, the end result is that there is abnormal distribution of forces to spinal discs --- or maybe more accurately, to parts of the disc where said force should not be. Allow me to give you an example.
While discs will often herniate some degree laterally, they virtually always herniate backwards (posterior), meaning that herniated discs --- mostly from the low back or neck --- have the potential to be pushed or squeezed into the spinal cord or spinal nerve roots that come from the cord. What does this have to do with maintaining normal lordotic curves?
These normal curves put an axial pressure on the backs of the discs (as opposed to the fronts of the discs). As you can see from the picture above, this squeezes down on the posterior aspect of the disc, while opening up the anterior or front of the disc and pushing it forward. This natural "wedging" of these discs makes it extremely difficult for the disc's jelly center (the nucleus pulposis) to herniate (because without a horrific trauma the disc will not herniate forward), and explains why you will sometimes see this spinal position referred to as "closed-packed". However......
Imagine what would happen to the low back or neck if there were either no curves, or even worse, a REVERSE CURVE. Now, instead of the discs having the "open" portion of their wedge to the front, the open part of the disc faces the back. This is what happens to your lumbar spine if you bend forward and touch your toes. No big deal. That is, no big deal until you start loading the spine. Imagine, however, bending forward and lifting something, while not consciously maintaining the normal curve in your back.
Not only are you opening the disc in the back, but the heavier the object you are lifting (or the more overweight you are), the more pressure you are exerting on the front of the spinal column and discs, as opposed to them carrying this force on the posterior parts of the spinal column (the facet joints). This pressure literally squeezes the disc backwards like squeezing a tube of toothpaste. When there is too much force, or more likely, too many years of poor lifting mechanics, the ligamentous fibers of the disc (the annulus fibroses) that hold the jelly-like nucleus in place begin to separate and tear. The result is that you are now in a position where disc herniations are not only possible, but increasingly probable (HERE is a basic video of what this looks like).
Let's add one more variable to this situation. Let's do some situps. After all, everyone knows that situps are good for your back because strong abdominal muscles promote strong discs ---don't they? Enter Stuart McGill. Decades ago, McGill was the lone voice in the wilderness, warning that situps were not only not good for your back, but were arguably one of the single worst things you could do to your spine. His research has shown why situps are one of the best ways to cause spinal problems, including herniated discs (HERE).
In a recent interview with Dr. William Morgan (A Conversation with the Preeminent Lumbar Spine Researcher: Stuart McGill, PhD); after discussing overuse of spinal imaging, McGill made this statement concerning what's arguably the single most common spinal finding on radiologist's reports DJD or DDD (degenerative joint disease . degenerative disc disease). "When they [radiologists] use the term degenerative disc disease, I put that in the same category as nonspecific back pain. It's a garbage term." Interesting because that is essentially what I said in THIS 2012 POST.
In the PORTION OF THE VIDEO INTERVIEW titled Mechanics of Injury For Lumbar Disk Herniations and Extrusions, those of you suffering low back pain will find some interesting tidbits as far as what put you there, as well as pointing you in the right direction to a solution. The biggest disappointment concerning this video was that two of the chief drivers of chronic back and neck pain were not really addressed; the first being SYSTEMIC INFLAMMATION, the other being micoscopic fibrosis or adhesion of the FASCIA, or more specifically, the thoracolumbar fascia (HERE, HERE, HERE, HERE, HERE, HERE, HERE, HERE, or HERE) --- a factor that increasing numbers of experts are saying is responsible for the majority (as much as 70%) of chronic back pain. I would argue that if you add these two modes of thinking to the knowledge and protocols created by McGill, your results will be better yet. Allow me to explain.
What do we know about back pain?
- We know that back pain is the world's number one leading cause of disability (HERE).
- We know that back pain and disc herniations are both considered "inflammatory" (HERE or HERE).
- We know that back pain is associated with increased potential of developing chronic neurological disorders and diseases (HERE).
- We know that in our sit-too-much society, both LOWER CROSSED SYNDROME and UPPER CROSSED SYNDROME are epidemics that are dramatically increasing in both numbers and severity.
- We know that there is an intimate relationship between chronic pain, chronic illness, adhesed fascia, inflammation, and fibrosis / scar tissue (HERE, HERE, HERE or HERE).
- We know that SCIATICA is often caused by VERY SPECIFIC FASCIAL ADHESIONS as opposed to disc herniations.
- We know that adjustments are helpful for many cases of spine-related pain (HERE). We also know that in many cases, these same adjustments don't hold very well (HERE).
Although I could have taken this list further, it helps explain why even though one cannot ignore the biomechanical aspects of back and neck pain, it's critical to realize there are other factors at play; particularly the chemical factors we refer to as "INFLAMMATION" --- a factor known to put people into a true CONUNDRUM.
If you are interested in shedding systemic inflammation and starting the process of RESOLVING YOUR BACK PAIN, be sure and take a look at THIS POST. It will at least provide a few ideas as far as creating your own personalized EXIT STRATEGY is concerned. Also, be sure to like, share or follow on FACEBOOK if you appreciated this post because it's still a great way to reach the people you love and value most.
MICHIGAN / INDIANA CHRONIC PAIN RELIEF
IN MOUNTAIN VIEW, MISSOURI
Dr. Russ, Good morning!
I came to visit you this past August. I was with my mom and we came from the Indiana / Michigan area. I keep forgetting to give you an update on the treatment you gave me. I found significant relief in my neck and upper back, with my chiropractic adjustments actually holding for longer periods of time now. I started exercising again in December, and my performance and pain levels are a lot better than when I was exercising last spring, before I came for treatment. I remember after the treatment my neck not hurting for the first time in a long time.
I still have some problems with my hip, pelvic, sacrum areas, which were my main concerns. I have a dull ache in my sacroiliac joint (at least I think that's where it is). And I totally can tell I still have some fascial adhesions around my hips and etc. I am working these out with my own fascia tools and Pilates, which seems to be a great choice for my body - a mix of harder work and stretching at the same time. I am also about to start some weight training again. However, if I can't make enough significant progress in the coming 6 months plus, then I will be returning to see you another time to work on these areas, or whatever needs worked on. Stress can really get my back and neck all tight again too. We have some bad winter weather over here and driving makes me tense up real bad.
Overall my entire body is doing much better. I noticed the biggest change when I started exercising again in December and how different it felt this time around post-treatment, versus pre-treatment. I ran on the treadmill the other day for a few minutes and was surprised to see how well I did compared to when I tried last year. Anyways, I had been meaning to write you, but finally got to it! Thank you for what you do! It helps lots of people and is the missing link that my doctors just cannot seem to wrap their brains around!
That's fantastic! Just let me know if you are this way again and we'll try to knock out the rest. BTW, I could not remember you immediately and looked at FB and remembered immediately. That pic with your husband and kids.... amazing! Also, would you mind if I posted this as a testimonial?
Absolutely you can use it! I tell everyone in pain about my journey and the role fascia & scar tissue have played. So shout it to the rooftops! I actually was just helping someone in pain today and told them about mine & sent them links to your blog to read about scar tissue. And yes I thought it might be hard for you to remember me since I came back in August. I actually debated on sending a photo to help! :) My sister is a photographer...that’s why that pic of my family is so good! Anyway, thanks again and maybe see ya in the future!
Allow me to give you a bit of background. The first thing you must realize is that Jenna's case presents a picture-perfect example of what I referred to in my post, "MUZZLED" ---- the all-too-common tale of vaccine damage denial. Bottom line, if reactions to drugs or vaccines are not reported to the proper governmental agencies, they are never counted among the adverse reaction statistics. Thus, whatever drug or vaccine looked at appears much safer than it is. Because the "ANTIVAXXER" rhetoric has been (purposefully) ratcheted up to a scream; whether dealing with topics such as FLU VACCINES, VACCINES in general, or vaccine sequelae such as AUTISM, there is no longer room for a conversation. For the record, numerous meta-analysis have shown that vaccine side effects are reported to VAERS (the government's Vaccine Adverse Event Reporting System) about 1% of the time (HERE). Not a misprint. Now, back to Jenna.
Jenna is a super-fit thirtyish mother of two young children. Always ultra-active, a TDAP SHOT she received while she was pregnant started this nightmare. She entered the world of CHRONIC PAIN, climbed on the MEDICAL MERRY-GO-ROUND, and started spinning. As you might imagine, she had been through all sorts of medical tests and treatments by the time I saw her, but had gotten off all of it except for the ANTIDEPRESSANTS and MUSCLE RELAXERS. The only things that actually helped Jenna were FASCIABLASTING and certain kinds of stretches / yoga. Even though Jenna's issues were "SYSTEMIC," I decided to see her once because I had a hunch I could help (her problems were fairly symmetrical left to right as well as being found both above and below the waist).
What did I determine from the examination and treatment? She had a combination SACROILIAC JOINT PROBLEM and SUPERIOR CLUNEAL NERVE ENTRAPMENT (as well as some HIP FLEXOR ADHESIONS), along with an array of FASCIAL ADHESIONS and connective tissue FIBROSIS, undoubtedly driven by an inflammatory reaction to the shot (remember that inflammation always causes fibrosis --- the medical word for what I refer to in my clinic as "SCAR TISSUE" or "DENSIFIED TISSUE" (HERE). One of the clues that I might be able to help Jenna was that chiropractic adjustments would help her, but the results were extremely short-lived (HERE or HERE) --- something that improved dramatically after her treatment. Speaking of treatment.....
Although I turn down the majority of the people who contact me from around the world because, unfortunately, after providing me with a history, I don't feel I can help them; my pledge to my OUT-OF-STATE & INTERNATIONAL PATIENTS (not to mention most of my local patients) is simple ---- you will know whether my approach will help you after a single treatment. This does not mean that one treatment will be enough to "cure" you (as an old professor of mine used to say, 'the only thing cured is ham'), but you will know whether or not we are on track (HERE or HERE).
For those who want to dig deeper into the root causes of fibrosis-causing inflammation (something I highly recommend, whether you have visible / tangible problems or not), HERE is the post. And if you appreciate what we are doing in tiny MOUNTAIN VIEW, MISSOURI, be sure to show us some love on FACEBOOK since it's still one of the best ways to reach the people you love and value most.
MIRROR MIRROR ON THE WALL.....
WHICH GOVERNMENTAL HEALTH AGENCY IS THE MOST CORRUPT OF ALL?
In September of 2017, an organization was created named Foundation for a Smoke-Free World, whose stated goals including noble endeavors like anti-smoking education, funding of various kinds of smoking cessation programs, decreasing smoking-related illnesses, monitoring the tobacco industry, educating tobacco farmers on farming options in light of a soon-to-be smoke-free world, as well as funding research for all of the above and more. Furthermore, this was not the sort of donation seen on the cover of the local newspaper --- one person presenting another with a comically oversized check, while vigorously shaking hands, and cheeky smiles around. We're talking 1,000 million dollars here (1 billion over 12 years). The punch line? The company dropping the cash happened to be tobacco giant, Phillip Morris International, owner of six multi-billion dollar cigarette lines, including the ever-popular Marlboro brand.
None of this should be surprising. A 2008 study from the journal, PLoS Medicine ('A Good Personal Scientific Relationship: Philip Morris Scientists and the Chulabhorn Research Institute, Bangkok) showed how Thailand's Chulabhorn Research Institute (the leading environmental health science facility in Southeast Asia and headed by one Professor / Doctor "Her Royal Highness, Princess Chulabhorn, the daughter of the King of Thailand") was essentially hijacked by Big Tobacco's big money. "Documents reveal that ostensibly independent overseas scientists, now identified as industry consultants, were able to gain access to the Thai scientific community...." This was especially big considering that "it [CRI] has assumed international significance via its designation as a World Health Organization (WHO) Collaborating Centre in December 2005."
Not surprisingly, many of the law firms and consulting agencies who helped Big Tobacco with it's legal and image problems over the years are members. And if you look at the board, it reads like a Who's Who hall of fame for FINANCIAL CONFLICTS OF INTEREST (COI). About this COI; Dr. Derek Yach, the Foundation's head (he used to be head of the WHO's 'Tobacco Free Initiative' as well as Senior Vice President of Global Health and Agriculture Policy for PepsiCo) stated, "I see it less as a conflict of interest than a confluence of interest". I can buy that. The whole scam revolves around everyone involved making money --- a 'confluence' by anyone's definition.
It should not come as a surprise that Phillip Morris International uses these sorts of diversionary tactics to try and cover the fact that they market their products to children (see The Facts about Philip Morris International: Company Is Cause of the Tobacco Problem, Not the Solution on Tobacco Free Kids dot org). Listen to how Jonathan Liberman, the director of the McCabe Centre for Law and Cancer put it.....
"The relevant wording in the Certificate of Incorporation and the Bylaws does not support 'ending smoking' through activities aimed at prevention of uptake or cessation of use without replacement by other products. If that had been the intention, it would have been a simple matter to so provide. Patently, Philip Morris has a significant commercial interest in alternative products / harm reduction, whereas prevention of uptake and cessation of use, without replacement by other products, are not in its interests. At heart, what the arrangement between the Foundation and Philip Morris represents is an attempt to operationalize a perceived intersection between Yach’s ambitions and Philip Morris’s commercial interests that Philip Morris judges to be valuable enough to it to justify an (albeit conditional) USD960 million commitment. The USD960 million is to be spent on certain things only – not things that are obviously inconsistent with Philip Morris’s commercial interests. This – if individuals and organizations are prepared to accept the money on offer – will inherently and significantly recast the field of tobacco control research and practice. Clearly, such a recasting would be of substantial benefit to Philip Morris. To suggest that such an enterprise can be made 'independent' through technical governance fixes shows an awareness of a need for the Foundation to address a significant PR challenge, but it seems to rely on a rather hollow understanding of the notion of independence'."
Once light was shed on this incestuous relationship, incredulous academic / research institutions (at least they sounded incredulous) realized they had better bail on this foundation or be seen as beholden to industry. Although when it comes to the pharmaceutical industry, they are definitely beholden to industry (SOMETHING I'VE SHOWN YOU OVER AND OVER AGAIN), accepting research dollars from Big Tobacco is much harder to explain away --- most likely the reason for the title of a blog post in the British Journal of Medicine by Marita Hefler earlier this week (Philip Morris Smoke Free Foundation: Questions About Independence and Transparency, While Top Universities Distance Themselves).
If you want, you can read the report on the dissolution of this unholy marriage that was published in the February 6 issue of both Bloomberg and Fortune (Philip Morris Health Campaign Rebuffed by World Health Organization). Honestly, it's probably more like an annulment because even though these entities had clandestinely slept together; supposedly, money had yet to change hands. Honestly, it's a lot of huffy puffy rhetoric and harsh words by the WHO, but if this relationship had not be scrutinized so closely, they would be living with PMI in orgastic bliss for the next dozen years. Not to be outmaneuvered, Coke wanted in on some similar action.
Less than two weeks ago the public health journal, Milbank Quarterly, published a paper titled Public Meets Private: Conversations Between Coca‐Cola and the CDC. What can be learned about these "conversations" that seem all too similar to what took place inside the hallowed halls of the UN (the WHO is the medical branch of the United Nations)?
"There is growing understanding of how manufacturers of harmful products influence health policy. The strategies, approaches, and influences from such manufacturers that are detrimental to health have been termed the 'corporate' or 'commercial' determinants of health. However, while partnerships with the tobacco industry are clearly unacceptable for public health organizations, ties to other industries continue to be pursued."
Coca Cola had the CDC's ear because they wanted to "frame the debate" concerning the relationship between sugar, obesity, diabetes, cancer (see my Facebook post from earlier this week), and numerous others. But honestly, I'm neither shocked nor interested. After all, what else would you really expect from people who have a lot to gain (or lose) depending on how this debate is explained to the public (who could forget the way this debate between ANCEL KEYS & JOHN YUDKIN was originally described sixty years ago)? What I'm most interested in is the last sentence above ---- ties to other industries continue to be pursued.
It's not difficult to see just how widespread these relationships really are (see earlier link to my column on Evidence-Based Medicine a few paragraphs ago). What's hilariously two-faced about this particular situation is how one of the single most corrupt organizations in all of medicine --- the AMERICAN HEART ASSOCIATION --- publically denounced the CDC for this relationship. And herein lies the problem. The very same COI that seems so disgusting when engaged in by certain types of entities (say, big tobacco), is the norm when engaged in by certain other types of entities (say, big pharma). My favorite example? How many of you have gotten your flu shot this year? If so, be sure and read THIS SCATHING PIECE by my favorite medical doctor (my little brother).
And if you appreciate the time and effort that goes into providing you with valuable (and free) health-related information (LIKE THIS), be sure and spread the wealth. The easiest way to reach the people you love and value most is by liking, sharing, or following on FACEBOOK.
THE LATEST IN FASCIA RESEARCH
HIGHLIGHTS OF THE FASCIA CONGRESS
Fascia is made up of FIBROBLASTS (collagen-secreting cells), MYOFIBROBLASTS (cells that give fascia the ability to contract), telocytes (extremely long fibers that give fascia the ability TO CONNECT YOUR BODY AS A WHOLE, aiding in it's ability to act as A SECOND NERVOUS SYSTEM), fasciacytes (cells that secret the gel-like HYALURONIC ACID), along with numerous other components, including the new lymphatic circulatory system called the INTERSTITIUM. These channels have already been shown to be important in LYMPHEDEMA / LIPEDEMA, the spread of CANCER, in wound healing, in HOMEOSTASIS, as well as their ability to "remove pathogens". When the authors made the statement, "Interstitial fluid flow is essential for a properly functioning immune system," I couldn't help but thinking about one of the many incredible benefits of OUR BACKYARD TRAMPOLINE!
Also talked about were THE VARIOUS TYPES OF PAIN, with mention being made to the premises underlying DR. CHAN GUNN'S WORK --- showing that when exposed to the chemicals that make up the immune system mediators we collectively refer to as "INFLAMMATION," nerves within the tissue can become hyper-sensitized, leading to problems like HYPERALGIA / ALLODYNIA, which are both characteristics of an all-too-common phenomenon known as CENTRAL SENSITIZATION (the worst kind of chronic pain).
The same research team also showed how SPONTANEOUS DISC HERNIATIONS are related to both muscular atrophy and FATTY INFILTRATION of the low back muscles and THORACOLUMBAR FASCIA, mostly the result of unbridled inflammation coupled with lack of exercise (or maybe I should say, lack of the right kinds of exercise). This section of the study also mentioned treating pain by focusing on "improving sleep, depression/stress and negative affect." Interestingly, I just showed you how light is being successfully used to address to all of these (HERE). As far as exercise, they suggested starting "gently" (especially those of you struggling with FIBROMYALGIA or similar). Maybe this explains why I've become such a huge fan of WBV and use it myself almost every day.
What I found amazing, but not surprising was that when looking at the actual causes of back pain, disc-related pain accounted for less than 5% of all back pain. OSTEOPOROSIS accounted for even less, and DEGENERATIVE ARTHRITIS accounted for only about one in ten cases. What was the major culprit in most back pain? "By far the biggest source of low back pain from what Dr. Willard has found in the literature is myofascial-ligamentous pain, which seems to contribute to about 70% of cases."
Again we see the importance of the THORACOLUMBAR FASCIA (or HERE, HERE, HERE, or HERE) as well the reasons it's important to grasp concepts like UPPER CROSSED and LOWER CROSSED syndromes. And while there was little detail provided, fascia's relationship to WHIPLASH INJURIES was also discussed, as was the importance of PROPER BIOMECHANICS on preventing musculoskeletal injuries, particularly to tendons.
Along these same lines, there were biomechanical discussions about the fact that one of PLANTAR FASCIITIS' chief characteristics is that the fascia "THICKENS" --- something they now believe is likewise happening to the Tensor Fascia Lata muscle in people (mostly runners and jumpers) with ITB problems. The authors also discussed the relationship between weak feet and PF, suggesting that in societies where no one wears shoes, the population has better arches --- still another reason to start a "GROUNDING PROTOCOL" (not to mention it's benefits your proprioception --- one of fascia's primary functions --- HERE or HERE).
One last thing I must mention before winding down is the relationship of fascia to hormones, particularly FEMALE HORMONES. Dr. Carla Stecco of Italy is one of the world's leading experts on this relationship between FASCIA AND HORMONES, and had this to say.....
"Another finding important to facial tissue composition is that fascial fibroblasts contain sex hormone receptors, which can affect collagen expression. Dr. Stecco's team has focused so far on female hormones and found receptors for estrogen, relaxin, and estradiol. These sex hormones, in particular estradiol, stimulate secretion of collagen type 3, which is elastic and organized more like a web; they also seem to decrease secretion of collagen type 1, which produces large bundles of strong collagen fibers to create stiffer and stronger fascia. In addition, fibrillin (a glycoprotein secreted by fibroblasts) was found to increase expression during the peri-ovulatory phase and pregnancy, making fascia more elastic. Increased elasticity in response to sex hormones makes the fascia of the trunk more adaptable to change of volume during pregnancy, and it is valuable to understand the biochemical mechanisms by which these changes occur. Looking at postmenopausal women, Dr. Stecco's lab found decreased expression of sex hormone receptors, making fasciae less receptive to hormonal input and more likely to develop and maintain stiffness."
Because fascia is often at the root of any number of PAIN SYNDROMES, what kind of research is being done to help suffering humanity with problems that may very well be fascia-related? Because "endocannabinoid receptors have been recently identified in fascial fibroblasts," there is a great deal of work being done trying to influence the INFLAMMATION / FIBROSIS / SCAR TISSUE CONUNDRUM using CBD and similar. There is also research into using specific enzymes that break down hyaluron to lessen "FASCIAL DENSIFICATION" (something we seem to be doing a pretty good job of her in our clinic --- HERE).
"Clearly, much progress has been made and is being made in this direction. In the meantime, there are many scientifically validated options immediately available to reduce pathology and pain and improve wellness, including manual therapy and exercise."
Although I would never for even a moment call it comprehensive, at least on some level MY INFLAMMATION-REDUCING PROTOCOL addresses each and every one of the points brought up in this post. If you are looking for more posts on fascia, HERE THEY ARE (or HERE if you want them organized), just follow the links. And if you enjoyed today's post, don't forget to like, share or follow on FACEBOOK as it's still one of the best ways to reach the people you love and value most. After all, there are growing numbers of researchers touting fascia as both the beginning and the end of all disease and chronic pain processes (HERE).
PRACTICAL PAIN MANAGEMENT TALKS ARTHRITIS DRUGS
CONCLUDES THEY ARE INEFFECTIVE
Fortunately, every cloud has a silver lining and this one was sterling. Guess which (ahem) "medication" out-performed all comers? GLUCOSAMINE SULFATE --- a cartilage-building nutritional supplement that has been around for decades under an assortment of different names. Also on the list were "ANTIOXIDANTS" and HYALURONIC ACID, neither of which are drugs either (they were referred to in this article as "interventions" and as MONOTHERAPIES, were not shown to be effective). "Pain improvement remained significant only for glucosamine sulfate." Here's the double whammy for those wanting to remain drug-free as they get older; glucosamine sulfate and chondroitin sulfate were the only "medications" that actually increased joint (cartilage) space.
So; although I've written numerous DIY articles about helping people help themselves with arthritis pain (HERE and HERE are two of them), my larger anti-inflammation protocol is often almost magically helpful simply because arthritis is based on inflammation (itis is the Latin word for INFLAMMATION). That protocol can be found HERE. While far from being considered comprehensive for every person, it will provide the average arthritis sufferer a starting point --- something to look at and start to ponder as they start formulating THEIR OWN PERSONAL EXIT STRATEGY FROM PAIN. Oh; and if you enjoyed today's post, be sure to like, share or follow on FACEBOOK since it provides a nice way to reach those you love and value most.
STILL ANOTHER STUDY BLAMES ALZHEIMER'S ON A LATENT INFECTION: THIS TIME FROM A BACTERIA INSTEAD OF A VIRUSRead Now
A NEW STUDY BLAMES ALZHEIMER'S ON A DIFFERENT OCCULT INFECTION
THAN THE OCCULT INFECTION THE LAST STUDY BLAMED IT ON
"Porphyromonas gingivalis, the keystone pathogen in chronic periodontitis, was identified in the brain of Alzheimer’s disease patients. Toxic proteases from the bacterium called gingipains were also identified in the brain of Alzheimer’s patients, and levels correlated with tau and ubiquitin pathology. Oral P. gingivalis infection in mice resulted in brain colonization and increased production of Aβ, a component of amyloid plaques."
While discovering pathogens in the brain and linking them to a serious disease process is certainly an exciting scientific discovery, the central point of this article was that the team had identified a compound (a "small-molecule inhibitor") that may block gingipains from entering the brain. Nice. Really, it is. Just realize that this paper was essentially a PRESS RELEASE masquerading as a scientific study, promoting a still-in-the-works "NEW DRUG" --- something that's become routine in our brave new world of EBM. Truth is, you are going to see more and more studies just like this one as the population becomes increasingly unhealthy (HERE'S THE SIMILAR RESEARCH PERTAINING TO BRAIN-BASED HERPES VIRUS CAUSING ALZHEIMER'S).
You see, as people become INFLAMED (almost ubiquitous in our society), a common consequence is that the immune system, of which 80% RESIDES IN THE GUT, goes haywire, becoming either suppressed or provoked; sometimes both at the same time (HERE), much of which can be attributed to a phenomenon called LEAKY GUT SYNDROME (the medical community typically refers to this as 'increased intestinal permeability' or similar).
What people often fail to realize, however, is that this very same inflammation can lead to leakiness of any of the body's protective epithelial barriers --- including the blood brain barrier (BBB). When the BBB is disrupted, people end up with a phenomenon that the scientific community has coined, LEAKY BRAIN SYNDROME (along with leaky cord syndrome, leaky nerve syndrome, etc, etc). Couple this with the two-sides-of-the-same-coin facts below and you should start to see the writing on the wall.
- ALZHEIMER'S IS OFTEN REFERRED TO IN THE SCIENTIFIC LITERATURE AS TYPE III DIABETES: Sounds crazy to some, but it's not really a new idea. Believe it or not, Alzheimer's Disease has been widely known as Type III Diabetes for more than a decade (HERE or HERE).
- SUGAR FEEDS INFECTION: Once you realize that SUGAR ALSO FEEDS INFECTION, whether said infection is bacterial or viral (IT ALSO HAPPENS TO FEED CANCER), it's not a reach to see why, with 100 million citizens (and who-knows-how-many non-citizens) living with either diabetes or prediabetes (HERE), the already epic potential for HIDDEN OR "OCCULT" INFECTIONS is increasing daily.
Best guess is that as Westernized society becomes progressively inflamed (HERE IS A SELF-TEST to see if you may be inflamed), we will continue to find various and sundry species of bugs in the brain --- bugs capable of causing a wide variety of neuro-degenerative symptoms, Alzheimer's being just one of many (HERE is another). People, however, are always looking for an easier way than managing their health and inflammation levels than through diet and lifestyle. For proof, look no further than the unbridled hype promoted by this title from last Wednesday's issue of New Scientist (We May Finally Know what Causes Alzheimer’s – and How to Stop it).
"Cortexyme reported in October that the best of their gingipain blockers had passed initial safety tests in people, and entered the brain. It also seemed to improve participants with Alzheimer’s. Later this year the firm will launch a larger trial of the drug, looking for P. gingivalis in spinal fluid, and cognitive improvements, before and after. They also plan to test it against gum disease itself. Efforts to fight that have led a team in Melbourne to develop a vaccine for P. gingivalis that started tests in 2018. A vaccine for gum disease would be welcome – but if it also stops Alzheimer’s the impact could be enormous."
Not very reassuring ("it seemed to improve participants"); especially in light of the article's headline. Like I said; the whole thing was a brilliantly calculated press release for the upcoming release of their patented gingipain inhibitors. But really; knowing what we know about the relationship between oral health and overall health (HERE and HERE are two examples of thousands), can we be astonished at these sorts of findings? It would not surprise me to see that in the near future, similar discoveries become almost passe. What might I suggest for those not wanting a GINGIVITIS VACCINE or something similar?
Rather than waiting until you are diagnosed with a nasty disease (periodontal disease included), start taking the steps required to reduce systemic inflammation in your life (WHICH ALSO HAPPENS TO BE GOOD FOR ORAL HEALTH). HERE is one way to start the process. And if you thought today's post was valuable or helpful in any meaningful manner, be sure to reach the people who need to be reached most (you know; the people you love and value most) by liking, sharing, or following on FACEBOOK.
FLU VACCINE FAILURE?
TAKE A GOOD LONG LOOK AT THE PERSON IN THE MIRROR
According to the scientific community's new flu-vaccine-excuse-bandwagon, it's not because we've become a nation of SUGAR ADDICTS (everyone knows that SUGAR FEEDS INFECTIONS), nor is it because nearly 80% of our adult population is overweight or appears as such when looking at their blood work (ANOTHER OF THE MANY FACTORS THAT DEGRADE FLU VACCINE EFFICACY). Neither do they tout any of the NUMEROUS REASONS we've heard previously --- from an MD.
Instead, it's because, ahem, "we’re all carrying a unique set of flu baggage — known as our imprint — that shapes how our immune systems respond to vaccines and infections." In other words, of the THOUSANDS OF COMBINATIONS & VARIATIONS OF FLU VIRUSES OUT THERE, your body seems to make a stronger / longer-lasting immune response against the very first one you were exposed to than it will to subsequent exposures or variations. Pay attention to these CHERRY-PICKED tidbits.
"A growing body of evidence suggests our immune systems aren’t following the instructions that the flu vaccine tries to give them. Experts know it [the flu vaccine] isn’t perfect. 'We’ve all been trained on different influenza viruses,' explained Scott Hensley, an associate professor of microbiology at the University of Pennsylvania who studies the factors that influence response to flu vaccine. 'If you vaccinate 100 people, guess what? They’re all going to respond differently. We think a large part of that is that we all have a different immunological imprint."
Hold the phone Sally! I thought that the whole reason that VACCINES were so safe (FLU VACCINE included) has to do with the "fact" that everyone responds essentially the same --- a contradiction I dealt with in a post I wrote JUST LAST WEEK. Interestingly, immunological imprinting is the phenomenon believed to weaken immune response to flu vaccine in senior citizens --- the reason that flu shots have been repeatedly shown to be all but totally worthless in the geriatric population (HERE).
Think about it this way. Say you got a case of H1N1 flu back in the LATE 70's OR EARLY 80's. According to these experts, not only will the 2019 version of your immune system not mount an efficient attack against flu vaccines containing other flu viruses (H1N2, H7N9, H3N2, H5N1, etc, etc, etc), but thanks to GENETIC DRIFT, it won't even mount an effective response to H1N1-containing vaccines because the modern version of the virus is so genetically different than the version that "imprinted" itself on your immune system ALL THOSE YEARS AGO.
This is why one of the experts interviewed for this piece suggested that, "The phenomenon is probably playing a significant role in the under-performance of flu vaccine" which might just be the understatement of the year thus far. Isn't it interesting that about the only time you hear the scientific medical community talking about how pathetic the flu vaccine really is happens to be when they are making excuses for it! And herein lies yet another dilemma.
When questioning whether a BABY'S FIRST FLU VACCINATION ---- which may actually occur IN THE WOMB if mom received a shot while pregnant (and was suffering with an all-too-common case of THE LEAKIES) --- might actually cause the same immune system imprinting phenomenon in little junior, the best they could muster was "That’s a really hot question," going on to suggest it would take years of research and heaven-only-knows how many millions of your tax dollars to find out.
In the meantime, the recommendations never change (GET YOUR SHOTS, EARLY AND OFTEN --- HERE'S WHY DOCTORS ARE NOW RECOMMENDING MORE THAN ONE FLU SHOT A YEAR), no matter what kinds of sordid facts are dredged to the surface concerning this ridiculously over-hyped vaccine. It's also why what I like to refer to as "THE ANNUAL HEAD SCRATCHER" (the yearly game of vaccine roulette played by industry concerning what combination of flu viruses will be chosen for next year's shot) doesn't matter nearly as much as we've been led to believe --- even though history has shown that pharma gets it right less than once a decade.
If you really want to maximize (NOT "BOOST") your immune system function, I've created a completely free post that will help with this by working to reduce systemic inflammation in your body (HERE). If you appreciate the time, energy, and effort that goes into bringing you relevant health-related information, be sure and like, share, or follow on FACEBOOK since it's still a good way to reach those you love and care about most.
CAN WE REALLY SAVE THE PLANET BY ELIMINATING MEAT FROM OUR DIETS?
"This was clearly a highly biased group, and the outcome of their report was therefore inevitably a foregone conclusion. Convening a one-sided group on a topic cannot be expected to produce a balanced outcome. It would be like pretending to negotiate an agreement in Congress with only one party at the table. Like-minded people talking to themselves is not a scientific debate, and the product of these inbred conversations cannot be considered a scientific product." Nina T, chiming in from her blog (discussed below)
I bring this up because one of the oldest and most celebrated medical journals in the world (LANCET) recently published a position paper (you would be correct in calling it a "MEDICAL GUIDELINE"), by 37 authors, titled Food in the Anthropocene: The EAT–Lancet Commission on Healthy Diets From Sustainable Food Systems. Citing "potentially catastrophic damage to the planet," the authors called for a new "planetary health diet" that among other things, would dramatically reduce meat consumption, while saving 11 million lives a year in the process.
"Food systems have the potential to nurture human health and support environmental sustainability; however, they are currently threatening both. Providing a growing global population with healthy diets from sustainable food systems is an immediate challenge. Although global food production of calories has kept pace with population growth, more than 820 million people have insufficient food and many more consume low-quality diets that cause micronutrient deficiencies and contribute to a substantial rise in the incidence of diet-related obesity and diet-related non-communicable diseases, including coronary heart disease, stroke, and diabetes."
This paragraph is dealing with two totally separate and distinct problems; one involving dietary choices and the other involving people who are simply trying to survive. The part about the preponderance of low-quality disease-causing diets is true. Unfortunately, it's doubly true of modern (wealthy) societies that are LIVING ON PROCESSED FOODS AND JUNK (calories) --- an all-too-common way of eating that I have declared "UNSUSTAINABLE" on many occasions, even though healthy food is more affordable than most pundits like to claim (HERE).
What's possibly even more interesting, however, is that this same phenomenon is increasingly true of the third world (or recently third world); a population seen each day as becoming more 'Westernized' (HERE). Allow me to show you, for better or worse, some of the Lancet's dietary / nutritional targets ---- targets that were specifically designed to with the Paris Accord (which the US pulled out of) and the UN's Sustainable Development Goals in mind.
- THE PERFECT DIET IS A UNIVERSALLY HEALTHY DIET: While this sounds noble, because of radically different worldwide climates and cultures, the authors are calling it a "reference diet." For example, my Ethiopian daughters were used to eating curdled milk that was made by sitting it out all day in a glass jar in the summer sun. Undoubtedly great for one's MICROBIOME and GUT HEALTH, but I suspect most of us will be passing on that one (kind of like we might all be passing on THIS 'ULTRA-HEALTHY' FISH).
- THE PERFECT DIET IS HEAVY ON VEGETABLES: I can certainly buy this --- as long as politicians don't get involved and claim that pizza and tots with ketchup constitute four servings of vegetables (HERE). The paper's authors also said that the diet should likewise be heavy on fruits. I've shown you in recent posts that thanks to genetic modifications, are infinitely more sugar-laden than fruit of generations gone by, potentially leading to an array of health issues (HERE and HERE).
- THE PERFECT DIET IS HEAVY ON WHOLE GRAINS: Whole grains are certainly better than processed grains (which were, as they should have been, suggested to be totally avoided). But thanks again to genetic engineering, they are not everything they've been made out to be (HERE). The authors also suggested that Americans should be eating something like six times more BEANS than we currently are.
- THE PERFECT DIET INCLUDES... "low amounts of seafood, poultry, red meat, processed meat, added sugar, and starchy vegetables". Some of this is good. Plainly stated, SUGAR IS A HIGHLY ADDICTIVE POISON. But comparing red meat to processed meat hearkens back a post I wrote on this sleight-of-hand nearly four years ago (HERE). In similar fashion to what I said about fruits above, these researchers did specifically talk about (white) potatoes being problematic due to their extremely high glycemic ranking.
- THE PERFECT DIET IS HIGH IN UNSATURATED FATS AND AVOIDS SATURATED FATS: Rather than rehash this topic again, simply look at my post on FATTY ACID METABOLISM as well as my post on COCONUT OIL, reading them in light of yesterday's post on the utter corruptness and FINANCIAL COI found in today's BIOMEDICAL RESEARCH and MEDICAL / DIETARY GUIDELINES.
Although there are many aspects of this diet I can heartily agree with (no pun intended), we have to remember it's source. Not surprisingly, the journal it was chosen to be published in (Lancet) has, over the past decade, acquired a decidedly left-leaning bent. Lest you doubt me, realize that they have actually been arguing that the world's healthcare woes could all be solved and that everyone would be better off if we were all living under Marxism / Communism (I'M NOT LYING FOLKS).
What I was planning on doing for today's post was to look up the financial or philosophical / religious conflicts of interest for at least some of the paper's 37 authors; an endeavor that even though I would enjoy doing, was going to require a significant amount of time. Thank goodness for NINA TEICHOLZ'S two day old blog post, Majority of EAT-Lancet Authors (Over 80%) Favored Vegan/Vegetarian Diets.
Nina T, author of the best-selling book, The Big Fat Surprise, revealed that of the 37 authors, 31 of them espoused veganism / vegetarianism prior to this paper. Rather than me providing you with a synopsis, I suggest you take a look at her short post yourself (HERE). Suffice it to say that it's painfully obvious that many in this group have an agenda --- an agenda that in some cases could only be characterized as "radical" ---- a word frequently bantered around by proponents when describing this paper.
"It's the first science-based diet that tackles both the poor food eaten by billions of people and averts global environmental catastrophe has been devised. It requires huge cuts in red meat-eating in western countries and radical changes across the world." From The Guardian
Conflicts of interest, however, are not the only problem with the Lancet's diet recommendations. Nutrition and public health authority, Dr. Zoë Harcombe, recently made a powerful accusation via the title of a post on her blog; THE EAT LANCET DIET IS NUTRITIONALLY DEFICIENT. She used various governmental tables to compare EAT to current caloric and nutritional RDA's, concluding that the Lancet diet is deficient in "iron, Omega-3's, calcium, potassium, sodium, vitamin K (particularly K2), vitamin D, retinol, and B-12" --- many of which are significantly deficient. Dr. H, an ex-vegetarian who says that she "respects all personal choices in this delicate area," ended her article with this statement.....
There are numerous other issues with this plant-biased advice. Not least – what will all these plants be grown in when there is no top soil left because we have replaced soil-rejuvenating ruminants with soil-raping plants?
Although "rape" might be a bit too strong a word for what she's describing here; she's mostly right. It was only last month that I showed you that in order to regenerate or build soil in an area bigger than your backyard garden; not only does it require livestock, but it requires lots of livestock ---- rotated and managed in a highly orchestrated and systematic fashion (HERE). The truth is, you can't do it without animals; no matter what anyone tells you. These philosophical differences in farming are what's created the chasm between the nutritional composition of meat that's raised in a sustainable fashion (see above link) and meat raised in commercial feedlots.
As crazy as it may sound to those hearing it for the first time; I'll repeat myself. In order to heal soil that's been continually and relentlessly raped, not by plants themselves but by decades of COMMERCIAL CHEMICAL FARMING, we don't need less livestock, we need more. We simply need to manage these animals in a manner consistent with the link in the previous paragraph. So; if you want to avoid animals or animal products such as eggs, milk, cheese, etc, etc, make sure you are doing it for reasons other than because you feel it's healthy or is the key to saving the planet.
For people struggling with chronic health conditions, HERE is part of the generic regimen I suggest you research to help you get better. And if you appreciate our site, be sure and like, share, or follow on FACEBOOK as it's a great way to reach an audience of people you love and care about most.
MEDICAL GUIDELINES HAVE BECOME A
GET RICH & FAMOUS SCHEME
DR. JOHN IOANNIDIS got the ball rolling by revealing just how influential medical guidelines really are. One of the examples he used was that a simple change in the definition of what constitutes a specific disease (for instance, lowering what's considered "normal cholesterol levels" --- something that's been done numerous times over the past three decades) has the power to dramatically increase both doctor visits (specialists included) and prescriptions of an array of drugs, including ever-controversial STATINS. The specific diseases he listed include but are not limited to.....
- GERD: This one is interesting because thanks to mountains of research, the dangers of the drugs used to treat it have been increasingly exposed by the media over the past two or three years. Unfortunately, the average physician doesn't really understand the physiology of ACID REFLUX or the PPI DRUGS commonly used to treat it.
- DIABETES: There are over 30 million diabetics and another 70 million functional diabetics (PREDIABETES / METABOLIC SYNDROME) living in the US. Change the guidelines of what constitutes normal blood sugar, and huge numbers of pre-diabetics are magically converted to diabetics with the stroke of a pen. Doctors are obligated to follow a whole host of treatment rules with diabetics that they are not with pre-diabetics (i.e. diabetes is a cash cow). What's even more telling is that we've known for some time that diabetic drugs are doing little beyond changing surrogate endpoints without significantly altering morbidity or mortality (HERE).
- DEPRESSION: Nowhere are recommendations for who should be on antidepressants and who should not more scrambled than our nation's DEPRESSION GUIDELINES. This coming from a class of drug that has been shown in repeated meta-analysis to be all but totally worthless (HERE).
Although there were several others mentioned, what interested me most was that all fell under the category of INFLAMMATORY DEGENERATIVE DISEASES or AUTOIMMUNE DISEASES --- diseases that people can typically change / improve through diet and lifestyle (HERE). After sharing that the phenomenon of altering disease definitions has the potential to add billions to our already burgeoning healthcare budget, Ioannidis went on to ask the question; "Should the specialists of the respective field be the developers for such influential articles?"
On Wall Street, being an "insider" can have you thrown in jail (HERE). On the campuses of our pharm-funded medical research institutions, you had better be an insider if you hope to gain recognition or access to real money. Dr. I's paper also discussed how not only are the most commonly-cited scientific papers for any given year medical guidelines, but these guidelines often have dozens or even scores of authors, in some cases exceeding one hundred. Listen to how he described it.
"Hundreds and thousands of designated guideline coauthors share in the society-wide power game across a large portfolio of guidelines and statements that improve, fine tune, or manipulate disease definition and management. Tens of thousands of society members then cite these articles. This creates a massive, clan-like, group self-citation network."
Ah; the good-ole-boy network. When I hear that term, my mind automatically slides back to clips from 1988's MISSISSIPPI BURNING; a historical portrayal of a good-ole-boy network that was more Klan-like than clan-like, with everyone covering (lying) for each other, knowing that if one of them went down, the dominoes might start falling, with everyone ending up in prison. What would the medical experts that create the guidelines --- the "superstars" of their respective specialties if you will --- need to cover up en masse?
The word superstar is in quotes because it was used by the author to describe doctors / researchers that have even one study cited by over 2,000 other study's authors. Interestingly, Ioannidis provided evidence that the average Nobel Prize winner had no more than one such paper (obviously the one they won their prize for). In other words, it's a rarity. That is, unless you happen to be authoring the "clinical guidelines, disease definition statements or disease statistics" that the profession is essentially forced to read and follow (see quote at top of page).
Ioannidis not only had an interesting chart titled A Sample of the Most-Cited Authors in Cardiovascular Medicine, but it contained "6 scientists who have coauthored 8 or more guidelines with over 2,000 citations each." A few had more. What does this really mean? It means that a small group of academic elites are running the show. This might not be a big deal in and of itself, except for their ties to industry. Makes me wonder if we are talking about medical guideline authors or the United States Congress?
Remember back a few months ago when I showed you how some of America's top cancer doctors (MD Anderson / Sloan Kettering / others) were being paid extraordinary amounts of money to conduct and report cancer research in a certain manner (HERE) --- a situation that becomes even starker once you realize fewer than 10% of these studies can actually be reproduced (HERE)? Something similar is going on with large numbers of the creators of our medical guidelines. And honestly, it's not just the guideline creators themselves, but the journals that carry them. There are huge financial incentives for the journals that publish medical guidelines. After picking on European journals first (Ioannidis is, as his name would imply, Greek) he took a swipe an the worst-offending American journals, including the very journal carrying the paper we are currently discussing, Circulation (the official journal of the AHA).
"In the US, similarly, most of the top-cited articles in Circulation are disease statistics, disease definitions, and American Heart Association/American College of Cardiology guidelines. Nine of the 10 articles contributing the most to the 2016 impact factor of European Heart Journal and 8 of the 10 articles contributing the most to the 2016 impact factor of Circulation are guidelines, disease definitions, or statistics.... Some professional societies are behemoth financial enterprises. Massive producers of medical guidelines and of disease definitions tend to be the largest financial players, again with cardiology being the leading example. For example, the annual American Heart Association budget in the fiscal year 2016–2017 was $912 million, 20% of which came from corporate support."
I have oft-written about the ridiculous and blatant corruption in both the AHA and the ACC, hidden behind their ivory towers and white coats, putting out scientific-sounding studies like THIS, THIS or THIS. As far as corporate support, Ioannidis simply showed us another case in a steady stream of cases of the fox guarding the henhouse. The author did say that guidelines have the potential to be useful before revealing that most such guidelines have "one or more red flags that either make them overtly unreliable or should at least raise suspicion among potential users." Again, reread the quote at the top of the page.
Dr. I went on to list some of the things that make guidelines untrustworthy; but honestly it would take volumes to compile them all for you (I've done my best in THESE FIFTY-PLUS POSTS ON EBM). Suffice it to say that once you grasp the almost endless number of ways you're being screwed by BIG PHARMA, BIG GOVERNMENT, BIG RESEARCH, BIG CHEMICAL, BIG FOOD, BIG HEALTHCARE, big guidelines, big etc, big etc, big etc, you may, like exponentially increasing numbers of others are doing, start questioning everything that's recommend; CRAZY VACCINE SCHEDULES INCLUDED!
Although there were plenty of ideas kicked around to put an end to this fiasco, I'm not holding my breath that it will happen anytime soon. There's simply too much money at stake ---- something I showed you in a link provided in this recent article (HERE). My hope is that you do what it takes to stay healthy so that guidelines aren't something you even need to think about.
My recommendations / guidelines are somewhat different. I simply provide some ideas, point you in the right direction, get you thinking and researching a bit differently (a bit off the beaten track), and watch cool things start to happen (HERE). If you enjoyed this post or know people who would love to break free from the medical merry-go-round they're living on, point them to our site. And be sure to like, share, or follow on FACEBOOK as well since it's still as good a way as any to reach those you love and value most.
PULITZER PRIZE WINNING SCIENTIST, RENE DUBOS, SHARES HIS THOUGHTS ON THE "GERM THEORY" OF DISEASE
"Everyone harbors disease germs, yet not everyone is sick. This is ascribed to 'resistance,' suggesting that germs are less important in disease than other factors affecting the condition of the host." The header of a 1955 article published in Scientific American (Second Thoughts on the Germ Theory) by renowned scientist, Rene Dubos
Dubos attended university in Paris (The Institute of Agronomics) where he excelled in the field of, you guessed it, agricultural economics. But despite his successes, ag econ was not his true calling. Dubos' 1989 biography discussed how his intellectual focus changed a few years after the Great War.
"In 1922, Rene obtained a position in Rome on the staff of the International Institute of Agriculture, a branch of the League of Nations. For two years, as associate editor of the International Review of the Science and Practice of Agriculture for the Bureau of Agricultural Intelligence and Plant Diseases,he abstracted journal and agricultural reports from all over the world. He now spoke Italian and English as well as French and German. Rene recalled his days in Rome as very pleasant. He was a handsome young man with a bushy head of hair who was particularly attracted to English girls, ostensibly to improve his language skills. At this time he was undecided about career goals, considering occupations as divergent as journalist and scientist."
After being exposed to a scientific paper by Paris's renowned soil biologist / microbiologist, Serge Winogradsky, Dubos changed professions, eventually landing at Rutgers after earning enough money to make the cross-Atlantic trip by translating studies on agriculture and forestry from several languages into French. Once in America it didn't take long to establish himself as an intellectual force, earning his Ph.D in microbiology in 1927 (his thesis was on the way in which bacteria in soil decomposed the fibrous part of plants called cellulose).
After landing at The Rockefeller Institute (the institution that interestingly enough was responsible for bringing us the unscrupulous FLEXNER REPORT), he began a major survey and study of soil throughout both the United States and Canada, earning academic acclaim for three new and distinct ideas.
- The idea that bacteria nourished in the proper environment can produce enzymes specific to themselves.
- The idea that in infectious diseases, bacterial by-products stimulate immunity to said bacteria.
- The idea that environmental stressors affect the development of the organism as a whole (today we would probably refer to these stressors as EPIGENETIC FACTORS).
The authors went on to reveal the result of Dubos' new way of thinking.......
"His interests progressed from studies of pneumonia and tuberculosis to the whole pattern of disease and, finally, to the quality of human life on earth. The unifying thread in this seeming diversity was his perception that any living organism, whether microbe, man, or society, can be understood only in the context of the entire web of relationships it forms with everything else."
Dubos is talking here about a concept I have dealt with extensively on my sidte concerning both WHOLE FOOD NUTRITION and FASCIA. Modern, Westernized science breaks things down (organisms, soil, humans, bacteria, plants, food, etc), separating them into their tiniest microscopic components, always looking for a compound or chemical that will prove to be the magic bullet in the quest against CANCER, OBESITY, or who-knows-what-else. The problem is, MONOTHERAPIES (chemicals or compounds in isolation) rarely do what's claimed of them.
In other words, Dubos believed that the whole (organism, food, field, forest, etc) was much greater than the sum of its individual parts, which provides us with a good description of the chief difference between MECHANISM & VITALISM (or HERE). Mechanistic (Westernized) medicine believes that all of ill health's secrets will one day be unlocked by purely mechanical 'cause-and-effect' thinking, while vitalists realize that there is something about living organisms and ecosystems that cannot be understood apart from the whole.
What's equally as interesting along these same lines is that even though Fleming gets the credit for discovering antibiotics, not only did Dubos do a great deal of the early heavy lifting in this field, he also predicted that bacteria would eventually become "resistant" to these various antibacterial compounds (ANTIBIOTIC); a concept we are all too familiar with today (HERE). And unlike many of his peers, he was not under the delusion that antibiotics were wonder drugs that would wipe sickness and disease off the face of the earth, such as became widely promoted by the scientific community in the 1950's, not to mention by LBJ's GREAT SOCIETY in the 1960's.
During WWII, Dubos' wife died of the recurrence of a latent TB infection, leading him to start heavily researching infectious tuberculosis. Notice, however, the 'epigenetic' manner in which he thought about this disease. "Rene began with the conviction that tuberculosis became an important social disease only under certain social conditions". We talked about some of these conditions IN MY LAST POST, which, although happened to be on autism, could just as easily been about any of the 85-90% of all diseases that are not genetic (yes; way too many doctors continue to promote a genetic etiology of "LIFESTYLE DISEASES" to their patients). Not surprisingly, in the myriad of papers Dubos published on TB, one of his favorite areas of study was, "the effect of diet on the course of experimental tuberculosis in laboratory animals."
In other words, Dubos continued to shed Pasteur's idea that germs themselves were the cause of disease, while standing on the shoulders of scientific giants like Claude Bernard, Antione Bechamp, Ilya Illyich Meshnikov, and Rudolph Virchow, all of whom were alive when he was, and all promoting similar ideas --- ideas that were being hijacked by industry right under their very noses. What's important to remember is that despite their collective scientific achievements, in many ways these men became pariahs because of their belief that the health of the organism ("the soil"), was far more important than whether or not they had been exposed to some germ or another (HERE). Not surprising considering what the authors wrote about Dubos' original mentor, Serge Winogradsky.....
"Winogradsky stated that microorganisms should be studied not in a pure laboratory culture but in their own environment in competition with other bacteria. He emphasized interactions of organisms under natural conditions and the significance of the role played by the environment in these interactions. Rene said his scholarly life began with these ideas—ideas he restated in many forms throughout his life."
There it is again folks; the whole is greater than the sum of its parts! But, as medicine's emphasis on treating infectious disease shifted from long-term solutions (looking at epigenitic factors that affected the health and immunity of the host) to short-term band aids (drugs that killed germs or altered symptoms without really ever addressing underlying pathophysiology or immunity), Dubos became increasingly frustrated, turning his attention towards environmental advocacy, lecturing, and writing a number of books (he won a Pulitzer Prize in 1969). Listen to what these authors said of him concerning this era.....
"The key book resulting from Dubos's thoughts about illness, and his most popular work, was Mirage of Health (1959). Embodied in its title is his ecological view that man will never be free from disease because he must continuously adapt to environments in flux: Disease results from the dynamic process of life. In Dreams of Reason (1961), he questioned over-confidence in science's ability to eliminate disease, advocating, instead, using the means and knowledge of science to determine the kind of health society wants. A more explicit, scientific statement of his views on environmental biomedicine appeared a few years later in Man Adapting (1965), which emphasized that states of health or disease are organisms' adaptive responses to environmental challenges."
I bring up the 1950's because of an article that expert in hormones and mitochondrial dysfunction, DR. CHANDLER MARRS, posted the other day. You see, back in May of 1955, Dubos wrote a piece for the oldest science publication in the United States, Scientific American, concerning this very topic. The article's provocative title? Second Thoughts on the Germ Theory.
Before I begin, you must remember that Louis Pasteur (the man who came up with the germ theory) was not only primary of Dubos many scientific heroes, but Dr. Dubos actually published a biography on Pateur in 1950 titled Louis Pasteur: Free Lance of Science. Understand that for Dubos to write an article with this sort of title, went not only against today's current thought, but against the current thought for that era as well, not to mention the fact that it was essentially a rebuttal of some of the biggest aspects of Pasteur's work. Need proof? Take a peek at the article's shocking header (it's the quote at the top of the page). Why would this have been so controversial within the scientific community of that day? Because it's almost exactly what 'quacks' like the developer of the chiropractic profession (DR. BJ PALMER) repeatedly said during their careers. It also happens to be the foundation of a field of study known as epigenitics.
We grew up being told that the field of GENETICS was, like the field of microbiology and bacteriology before it, going to solve all of humankind's health woes. Not only has this not panned out, but infectious diseases are being fingered as the chief culprit in growing numbers of diseases that were originally believed to be genetic (and as I said earlier, are still being promoted as such by far too many doctors). How important has the field of epigenetics become? In Y-2K there were ten studies published on the subject. Ten years ago (2008) PubMed showed 240 studies with the word "epigentic" in the title. By last year, that number had increased over ten-fold to almost 2,700 published studies. Epigenetics are important because it's today's best example of the concept Dubos was trying to get through to his readers sixty five years ago.
Dubos began his 1955 paper by suggesting that the germ theory of disease --- germs find susceptible hosts and multiply --- was grossly oversimplified. He explained this by arguing that there have been plenty of critics of the the Pasteur / Koch theory since its inception in the 1870's, not the least of whose reasoning included the fact that healthy animals / humans were frequently surrounded by the sick, yet did not get sick themselves. He went on to describe followers of the germ theory as having three distinct characteristics.
- They are "almost cultish" in their love of and defense of the germ theory.
- They are "undisturbed by the inconsistencies" of their theory.
- They are "not too exacting about evidence".
Remember; this was 1955 --- long before today's emphasis (no matter how TWISTED OR OXY-MORONICAL) on evidence-based medicine. Furthermore, listen to how another 'quack,' Dr. DD Palmer --- the founder of chiropractic back in the late 1800's --- described this same phenomenon in relation to the humble beginnings of the profession.
"For ten years I had been looking, thinking, asking myself and others the question, why does one person have a certain ailment and another remain well, although both may be eating the same food at the same table, sleeping in the same bed and working side by side? At last Harvey Lillard assisted me in answering my question. He told me that while he was in a cramped position he felt something give way in his back and from that time he was deaf. Upon examination I found a vertebra out of alignment, racked out of its normal position. I replaced it by two adjustments and restored his hearing."
The point here is not that chiropractic adjustments are the cure for deafness (LIKE THIS ONE WAS), or that germs aren't associated with disease on some level (they are). It's that exactly as BJ Palmer said probably 100 years ago, "The germ might well be the agent of disease, but the cause is much more complex than that. Otherwise, eventually no one would be alive to tell you about it!" Listen to the way Dubos described this same phenomenon. "Is it not possible that bacteria are only the secondary cause of disease --- opportunistic invaders of tissues already weakened by crumbling defenses?" And this, my friends, is the crux of the debate. Do germs actually cause disease, or do diseased (but in many cases asymptomatic) organisms simply attract germs in the same way that spoiled fruit attracts flies or ROTTING GRAIN ATTRACTS RATS? As is often the case, the truth falls somewhere in the middle; although he (and I) would argue closer to the latter.
But as far as the former goes (the point that germs are actually the cause of disease), Dubos was not silent. He went on to talk about various historical plagues that killed horrifying numbers of people. "These instances provide tragic evidence that a microbial agent may strike down the weak and healthy alike when introduced to a susceptible population." However, the fact that not only did everyone exposed to these plagues not die, but not anywhere near the majority, helps prove that Dubos was on the right track. And once natural immunity develops within the population, death rates plummet despite regularly being exposed. "Theories of disease must account for the fact. that in any community, a large percentage of healthy individuals continually harbor potentially pathogenic microbes without suffering any symptoms or lesions." Dubos went on to declare that most of his readers were harboring "virulent" staph and tuberculin themselves, yet would never know it because it would never manifest.
This itself raises an interesting question. Despite our best efforts to "cure" infectious disease, why are rapidly growing numbers of people plagued with illnesses that are increasingly believed to be the result of what Dubos referred to as "latent infections" (ALZHEIMER'S, DISC HERNIATIONS, EBV, PANDAS/PANS, IBS, FLACCID PARALYSIS, DISEASES FROM ROOT CANALS OR OTHER ORAL INFECTIONS, and on and on and on)?
He answered this by revealing that the most likely scenario is that these 'sleeping dogs' (my term, not his) will continue to lie until something wakes them. What might awaken a dormant infection? Here is Dubos' list (most of these are direct quotes or nearly so). Diabetes or other sugar dysregulation issues (AFTER ALL, SUGAR FEEDS INFECTION), being interned in a concentration camp or gulag (LIKE THIS), overwork, over-indulgence (both of which create SYMPATHETIC DOMINANCE), damp drafts, UNHAPPY MARRIAGES, FEVER, RADIATION, CHEMICAL TOXICITY (or HERE), SURGERY, MENSTRUATION, IMPROPER FOOD, etc, etc, etc. Honestly; what do these collectively remind me of? This list appears to be made up of the very elements that modern researchers would include in parenthesis just after mentioning epigenetic factors.
There is, however, an even deeper question raised by Dubos' paper; what are the results of a constant cradle-to-grave barrage of ANTIBIOTICS, CORTICOSTEROIDS, (FLU SHOTS INCLUDED), BIOLOGICS, and OTHER DRUGS (many of which are unarguably based on IMMUNE SYSTEM SUPPRESSION)? Interestingly, Dubos provided an answer. Listen to how true his words still ring today.
"It has been repeatedly observed that vigorous treatment with drugs of almost any type of virulent infection in a human being may have the paradoxical effect of bringing about another type of infection, caused by the proliferation of otherwise innocuous fungi and bacteria. We are beginning, in fact, to witness the appearance of man-made diseases, caused by the rapid changes in human ecology, brought about by these new therapeutic procedures."
Gulp! And he's not even talking about the absurd numbers side effects of drugs taken for non-infectious diseases (HERE), let alone the astronomical amount of medication (or range of vaccines) that the average citizen would one day become conditioned to believe is normal. I don't think even a visionary like Dubos could have foreseen our current pharmaceutical flood looming just below the horizon (HERE or HERE). A mastermind group that I am part of (there are brilliant people from a wide range of academic, athletic, and medical backgrounds --- AND THEN THERE'S ME) recently had a debate (blow-up would be more descriptive) over vaccines. At least partially in response, I wrote a short post on legal issues raised by brand new testimony concerning the vaccine / autism debate (HERE).
The point of my post was that unfortunately you can't, at least in most cases, know up front whether or not your child will be the one who reacts, as well as the fact that many of these reactions may not fully manifest for decades. Although Dubos was talking about antibiotics in the quote below, he could just as easily have been talking instead about vaccines (our government's national vaccine campaign did not begin for another 7 years in 1963 ---- HERE or HERE).
"The classical doctrines of immunity throw no light on precisely what mechanisms determine whether dormant microbes will remain inactive or begin to act up. What is needed to analyze this problem is an understanding of the agencies needed for natural resistance to infection, and of the factors that interfere with these agencies. Fortunately, interest into research in this area is increasing rapidly."
While his last sentence may still be true today on some level, don't kid yourself; it's only really true in terms of creating drugs --- a fact driven home by a recent discussion within the above-mentioned group (mostly by MD's) on the ABHORRENT STATE OF NUTRITION EDUCATION WITHIN THE MEDICAL PROFESSION. The truth, however, is exactly like Dr. Dubos stated after telling his readers that disease is all about the ecology of one's environment, both internal and external. "Whether man lives in equilibrium with microbes depends on the circumstances under which he encounters them." I love the word "equilibrium" here, implying a HOMEOSTATIC RELATIONSHIP between man and germ ---- the very thing required for health as per the HYGIENE HYPOTHESIS. What do I suggest you do with this information?
Firstly, realize that Dubos is correct in his assertion that "we cannot possibly eliminate all the microbes that are potentially capable of causing us harm." Trying to do so has created more damage than the average person could ever begin to comprehend. Secondly, it's critical to grasp that you wouldn't want to do this even if it were possible (see previous link as well as information on both MICROBIOME & DYSBIOSIS and their relationship to AUTOIMMUNITY). And thirdly, realize that even though this information is not exactly new, you can leverage it's main ideas to start taking your life and health back. After all, no one else --- not even your doctor --- can do it for you.
Although there are some of you that will require some very specific and uniquely customized approaches to your return-to-health plan (your "EXIT STRATEGY" if you will), for most of you --- that would be over 50% of you --- MY GENERIC HEALTH-RESTORATION TEMPLATE is enough to get you started. And if you know someone who could benefit from the cool (and completely free) information on our site, be sure and like, share or follow on FACEBOOK since it's still a great way to reach the people you love and value most!
IF VACCINES HAVE NO RELATIONSHIP TO AUTISM, WHY DID THE DOJ HARASS A PRO-VACCINE RESEARCHER WHO CAME TO CONCLUSIONS THEY DIDN'T LIKE?
"Vaccine hesitancy – the reluctance or refusal to vaccinate despite the availability of vaccines – threatens to reverse progress made in tackling vaccine-preventable diseases. The reasons why people choose not to vaccinate are complex; a vaccines advisory group to WHO identified complacency, inconvenience in accessing vaccines, and lack of confidence are key reasons underlying hesitancy. Health workers, especially those in communities, remain the most trusted advisor and influencer of vaccination decisions, and they must be supported to provide trusted, credible information on vaccines."
As seen over and over in my EVIDENCE-BASED MEDICINE column, there is an underlying but unasked question raised by this paragraph --- a question that needs to be asked in a slightly different manner. Why wouldn't people be reluctant to have their children (or themselves for that matter) vaccinated on a schedule that contains many times the number of inoculations (i.e. many times the TOXICITY) than when I was a kid? In fact, I would argue that the most significant of the "complex" reasons for questioning vaccines isn't even listed --- fear. People are afraid that those in power (big pharma, big government, big healthcare, big etc) are LYING TO THEM; in many cases for reasons that could only be described as purely financial (see first link in this paragraph).
A few days ago, just after putting a post on ALUMINUM ADJUVANTS on Facebook, I came across SHARYL ATTKISSON'S piece for The Hill titled How a Pro-Vaccine Doctor Reopened Debate about Link to Autism (HERE). Before I continue let me go on record and say that I do not believe that all autism is vaccine-related, nor do I believe that vaccinations have the potential to harm all infants and children equally and in exactly the same manner (HERE).
There is, however, too much evidence to completely dismiss them as the 'bigs' I mentioned earlier would argue. And just who might get autism from vaccines? Certain children (a 'subset' of children) that we don't, at least at this point, completely understand the reasons for (MITOCHONDRIAL DYSFUNCTIONS, though, are always at the top of the list). After reading Attkisson's article it seems that Dr. Andrew Zimmerman feels similarly. In a sworn affidavit that can be read in its entirety over at REAL FARMACY, he states...
"I explained that I was of the opinion that there were exceptions in which vaccination could cause autism. More specifically, I explained that in a subset of children with an underlying mitochondrial dysfunction, vaccine-induced fever and immune stimulation that exceeded metabolic energy reserves, could, and at least in one of my patients, did cause regressive encephalopathy with features of autism spectrum disorder."
For the record, Zimmerman is not, like many would call me, an 'antivaxxer' crackpot. He is a renowned pediatric neurologist, professor, and researcher (Columbia, Harvard, Princeton, Johns Hopkins, UMASS, you get the point), with a curriculum vitae that's (gulp) 26 pages long (see previous link). He also happens to be 'pro-vaccine'. However, after making the statement above to DOJ attorneys back in 2007 he was removed as the case's expert witness (he was working for the VACCINE COURT), with them choosing never to use him again. What I found surprising was that the case Zimmerman was involved with pertained not to a single case of autism, but to "a group of 5,000 vaccine-autism cases" all being 'tried / decided' together. What's less surprising is that this mess was hidden from the public.
"Once the DOJ lawyers learned of his position, they quickly fired him as an expert witness and kept his opinion secret from other parents and the rest of the public. What’s worse, he says the DOJ went on to misrepresent his opinion in federal vaccine court to continue to debunk vaccine-autism claims."
And we wonder why people have problems trusting the powers-that-be in government and industry, which in far too many cases have morphed into the same monster (HERE). Allow me to shift gears for a moment. Because when I listen to music I'm either listening to BLUEGRASS, 80's, AOR, or some sort of CCM, I was not familiar with the band, Owl City. I was introduced several years ago, while working out with my son (he was about 12 at the time). I let him choose the music and he had a catchy song called GOOD TIME playing on the stereo in our gym.
It was only recently, however, that I learned that Owl City's founder and lead singer, Adam Young, has a form of AUTISM know as Asperger's Syndrome. Like many with Asperger's, he was gifted with an area of genius --- in his case musical genius. Although the modern hymn In Christ Alone was penned in 2001, take a listen to Adam Young's version he released nearly a decade ago at age 24. And if you appreciate today's post, be sure to like, share, or follow on FACEBOOK as it's arguably still the best way to reach the people you love and value most.
OBESITY, LIGHT, LEPTIN RESISTANCE, AND THE BRILLIANT MADNESS OF JACK KRUSE
"Maple syrup comes from a tree that makes it from CO2, water, and sunlight using photosynthesis. That process is now known to be fully quantized. In fact, the entire food chain is based upon photosynthetic webs. Most food gurus ignore that formalism, for business concerns. Moreover, a mitochondrion samples this quantized process, by breaking all foods down to electrons and the light photons that have excited those electrons. Anyone who believes wellness really begins with food has a deep philosophical problem with Mother Nature, and her design of mitochondria, and its place in a cell." Dr. Kruse, from one of the many articles on his site mentioned in today's post.
"If you are doing things correctly, you should never need to exercise to lose weight." Something I have said many times and in many ways on my site.
When that person happens to be a practicing neurosurgeon (not to mention, like both Price and ROYAL LEE before him, a dentist as well as an oral / maxillofacial surgeon), I need to dig deeper. And when that person puts their money where their mouth is and loses 77 lbs in three months and 135 lbs in less than a year using a protocol he created after teaching himself quantum physics, I realized that I really need to dig deeper. Enter Dr. Jack Kruse; a man I've come to the conclusion is either crazy or genius, quite possibly with equal parts of both. Although he certainly has his detractors, his unique ideas are being increasingly supported by peer review. One of the best examples of Kruse's thinking comes from the opening paragraph of his paper called Why Perspective Matters.
"Circadian biology is so fundamental to sleep and metabolism but few people realize just how important it really is. It is more important than your macro or micronutrients. Most of you reading this really do not buy this because of the questions I get asked and all the comments I have seen made on FB, twitter, blogs, and on internet forums. The blogosphere is tied to macronutrient ratios. It is a fact that our neolithic mind has burned into our conscious beliefs. This post is about showing you why you might want to consider changing your perspective on things related to what you eat. What we are designed to eat is the answer to where our ultimate health really lies. When we choose to eat in spite of our biologic directives this is when illness, disease, or bad feelings tend to crop up and cause confusion to the patient. The best way for you to solve this situation is to think. I want you to think about the message your neolithic mind is capable of delivering to your paleolithic genome on a daily basis. Most of us are completely unaware of this biologic mismatch. It is my belief that it underlies much of what currently ails most of mankind today."
Could Dr. Kruse be correct? In light of the fact that there are literally tens of thousands of studies on circadian rhythms as related not only to sleep / wake cycles, but to the kind (frequency / color) of light that our body functions best with (HERE), let's listen what he has to say. Be warned; Dr. Kruse does not like to simplify things (he actually states this in his writings and lectures), and if I don't simplify some of these ideas for myself, I will never understand them to the point of making them useful. As is frequently the case, I will be CHERRY-PICKING, trying to draw out main ideas in as few words as possible.
One of the main points Kruse makes (I've heard him say this in several presentations) has to do with the timing of America's invasion of CHRONIC INFLAMMATORY DISEASES. Having previously always seen the downward slide of our national health tied to the rise of COMMERCIALLY-MILLED FLOUR and other PROCESSED FOODS, it's interesting to note that the inception of our current era of modern INFLAMMATORY ILLNESS and AUTOIMMUNITY likewise coincided with the growth of electric power and artificial lighting, not to mention people spending increasing amounts of time indoors instead of outdoors. Could Dr. Kruse be right in his belief that harnessing circadian rhythms and NATURAL SUNLIGHT (or similar frequencies) has almost limitless healing capabilities?
"Today, in the face of rampant heart disease, osteoporosis, diabetes, and autoimmune diseases like celiac disease, multiple sclerosis and thyroiditis, we have learned that America’s health crisis began with Tesla and the power grid in the during the last 19th century during the 'Electric Power Wars'. Scientists are now uncovering that the electric power grid and things plugged into it increase blood glucose without any added food source of carbohydrate. This drives altered signaling in cells. Today PhD researchers are blaming food for the etiology of mitochondrial disease, but the science of light is showing us this is a misplaced notion."
What makes this statement especially interesting to me is the part about the electric power grid having the capacity to increase blood sugar without any carbohydrate inputs. I have a dear friend who was electrocuted about a decade ago, when he grabbed hold of a live 440 amp cable while doing some demolition on an old house (the 440 had been direct-wired to the grid decades earlier and was still live even though the power to the building had been shut off). Among the plethora of problems this has caused is an inability to control his blood sugar without miles of daily walking and a diet that borders on perpetual fasting. Drugs and diets do nothing for him, with his blood sugar frequently hovering in a range between three and four times normal, none of which was the case prior to the electrocution (the problem started almost immediately after).
THE IMPORTANCE OF CIRCADIAN RHYTHMS
"Autoimmunity treatments, fruitfully pioneered in mouse models, can be disappointing or result in immunosuppression and opportunistic infections in translational trials. Many possible reasons exist, but one major, overlooked reason may be the treatment timing in relation to circadian oscillations of the immune system." From the January 8, 2019 issue of F1000 Research (Are We Aiming to Miss in Translational Autoimmunity Treatments?)
When I typed "circadian" into PubMed, I found (gulp) over 85,000 studies. To get an idea, however, of just how big and important this field of study really is, allow me to show you some titles that were published within the past three weeks (two were actually published yesterday)........
- Integration of Melatonin Related Redox Homeostasis, Aging and Circadian Rhythm (Rejuvenation Research)
- Alterations of Circadian Rhythms and their Impact on Obesity, Metabolic Syndrome and Cardiovascular Diseases (Critical Reviews in Food Science and Nutrition)
- Timing Matters: Circadian Effects on Energy Homeostasis and Alzheimer's Disease (Trends in Endocrinology & Metabolism)
- The Connection of Circadian Rhythm to Inflammatory Bowel Disease (Translational Research)
- Disorders of Body Weight, Sleep and Circadian Rhythm as Manifestations of Hypothalamic Dysfunction in Alzheimer's Disease (Frontiers in Cellular Neuroscience)
- Hypothesis: Ubiquitous Circadian Disruption can Cause Cancer (European Journal of Epidemiology)
- Circadian Oscillations of Cytosine Modification in Humans Contribute to Epigenetic Variability, Aging, and Complex Disease (Genome Biology)
- The Circadian Rhythm of Breakthrough Pain Episodes in Terminally-ill Cancer Patients (Cancers)
- Interplay Between Diet, Exercise and the Molecular Circadian Clock in Orchestrating Metabolic Adaptations of Adipose Tissue (Journal of Physiology)
- The Synchronized Clocks of the Host and Microbiota (Acta Physiologica: Oxford)
- The Role of Microbiome in Insomnia, Circadian Disturbance and Depression (Frontiers in Psychiatry)
- Calorie Restriction Reprograms Diurnal Rhythms in Protein Translation to Regulate Metabolism (The Official Journal of the Federation of American Societies of Experimental Biology)
- Circadian Rhythm Abnormalities in Parkinson's Disease (International Journal of Molecular Sciences)
- Circadian Blueprint of Metabolic Pathways in the Brain (Nature Reviews: Neuroscience)
- Circadian Disruption and Human Health: A Bidirectional Relationship (European Journal of Neurosciences)
- Metabolic Rhythms: A Framework for Coordinating Cellular Function (European Journal of Neurosciences)
- The Arrival of Circadian Medicine (National Reviews: Endocrinology)
- Circadian Regulation of Endocrine Systems (Autonomic Neuroscience)
- Melanopsin Retinal Ganglion Cells and Pupil: Clinical Implications for Neuro-Ophthalmology (Frontiers in Neurology)
You are probably starting to realize why someone with a background in neurology / neuroendocrinology would be uniquely suited to help unlock this mystery. For starters, look how many of these publications are either neurology or endocrinology journals ---- the two most complex medical specialties that also happen to be opposite sides of the same coin (you'll often hear the ENDOCRINE SYSTEM referred to as the neuro-endocrine system). Bottom line, affect your body's circadian clock and the number of potential problems you could end up with is literally off the charts!
A molecule that Kruse spends quite a bit of time discussing on his site and in his lectures / interviews is melanopsin. We don't have to go back very far to get to the time when rods and cones were believed to be the eye's only photoreceptors. Not only do we now know of others, melanopsin included, but we are learning they have functions that go far beyond vision. For instance, the chief job of melanopsin is not to help us see images, but to act as a light sensor that provides 'reflexive responses' to both the body and the brain, many of which have to do with circadian rhythms (melanopsisn is the likely reason that Dr. Kruse suggests sleeping in a room with zero light --- not even a digital clock). CNRS International (The Many Roles of Melanopsin) had this to say about this photo-optic protein.
"It has been shown to regulate a wide range of non-visual functions, such as the synchronization of the circadian rhythms and the sleep-wake cycle with the light-dark cycle. Two main mechanisms regulate sleep: the circadian mechanism, which determines the optimal time for sleep, and the homeostatic system, which keeps track of how long the body is awake and asleep, and triggers 'sleep pressure' when the body suffers from sleep deprivation. Though light was known to influence the circadian mechanism via melanopsin, its effects on non-circadian processes were considered minor. Now, in a recent study, a team from CNRS reveals that light detection by melanopsin acts directly on non-circadian mechanisms and that circadian and non-circadian routes interact with one another."
If you head over to Jack's site and do a search on melanopsin, you'll find articles like Reality #7: Blood & Chlorohyll Types and Food and Time #12: Is Adrenal Fatigue Due to an Altered Spectrum of Light? that are so outside the box your head will hurt trying to make sense of all the concepts he's linking together. Listen to this statement Kruse makes about melanopsin's relationship between the brain (HYPOTHALAMUS), the eye, sunlight, leptin, and your body's ability to heal.
"The outer portion of the retina is where the photoreceptor melanopsin is loosely covalently bound to retinol. Melanopsin/retinol controls the neural signaling along the central retinohypothalamic tract. This tract connects the retina to the suprachiasmatic nucleus (SCN) which controls the circadian mechanism. This tract continues on and connects the retina and SCN to the leptin receptor in the hypothalamus. The leptin system, in turn, controls all growth and metabolism of the organism and this system controls the circadian release of hormones from the pituitary gland using specific light frequency changes present in AM sunlight. In December 2017 we have proof melanopsin/retinol are now in human skin, subcutaneous fat, and the skins arterioles. I will remind you that the subcutaneous fat mass links to the leptin receptor in the hypothalamus too using leptin and adiponectin as fat hormones. He who controls the frequency of sunlight via the eye and skin, calls the shots for the anterior pituitary hormones and its effect on human behavior and illness."
Speaking of leptin, this paragraph is a great segue into our next area of discussion; leptin as it relates to both health and weight.
LEPTIN RESISTANCE & OBESITY SOLUTIONS
"Nice to see science catching up to my madness in print huh? Leptin should be the chemical that is light-controlled by the central retinal pathways between the retina and the hypothalamus which entangles the molecule to photons to connect between the neuroendocrine and immune systems in the brain to control thermodynamics of the organism. This master photonic hormone acts in the brain as an energy homeostasis regulating factor that triggers a decrease in food intake and an increase in energy consumption by inducing anorexigenic factors and suppressing orexigenic factors by inducing size and shape changes of other photonic hormones in the brain during day and night cycles in a complicated quantum dance. Its own synthesis is mainly regulated by food intake. Food is formed by photosynthesis UNDER THE CONTROL of the sun rays everywhere on Earth. This means food takes its directive from the sun’s specific frequencies which is contrary to the food paradigms viewpoints today. Since leptin is responsive to food it implies it really pays deep attention to spectral frequencies from light in the human environment to alter growth metabolism body wide. This effect causes eating-related hormones dynamism diurnally and seasonally, but also depends on energy status created locally by mitochondrial flux. Leptin also controls fecundity by controlling the sex hormone cascade because leptin synthesis can be suppressed by testosterone and increased by estrogen and progesterone due to a changing light environment. Now you can see science is no longer blinded by the food paradigm……….they are waking up to a new world order." A blog comment by Dr. Kruse, based on a study by six researchers (Consequences of Evolutionary Transitions in Changing Photic Environments) that was published in the January 2017 issue of Austral Entomology
"Health is about light, not food." One of Kruse's favorite sayings
Leptin is a hunger-inhibiting (satiety) hormone made within FAT CELLS (the name "leptin" comes from the Greek word for 'thin'), and while it's certainly oversimplified thinking, leptin is the opposite of the hormone ghrelin --- a hormone made mostly by cells in the stomach that causes the perception of hunger. If you understand the progression of living the high carb lifestyle to the point where one becomes diabetic (HERE), you understand what it means to be insulin resistant. Allow me to briefly explain.
BLOOD SUGAR (glucose) must be kept within a tight range, mostly by the hormone insulin, which moves sugar out of the blood and into your cells, where it is either used for energy or stored as fat. Increased consumption of sugar and simple or processed carbs cause increased amounts of insulin to be released by the pancreas, which over time, tends to saturate the cell's insulin receptors.
The result is that the body "resists" its response, dumping more and more insulin into the blood stream, eventually leaving the body immune to its effects. The worse this vicious cycle becomes, the higher one's blood sugar climbs. And while there are a number of drugs that lower blood sugar, they do a poor job of everything else claimed of them ---- namely decreasing strokes, heart attacks, etc, and death rates (HERE). Something similar can happen with leptin.
Going to PubMed and typing in "leptin-resistance" provided me with 8,000 leptin-related studies on topics ranging from PCOS, BREAST CANCER and other CANCERS, OBESITY, "increased adipose tissue fibrosis" (LIKE THIS), LEAKY BRAIN SYNDROME, DYSBIOSIS, "cognitive impairment" (LIKE THIS), "infectious diseases" (LIKE THIS), "heart disease," OXIDATIVE STRESS, SLEEP APNEA, OUT OF CONTROL INFLAMMATION, along with too many others to count --- and this was only looking at the first 60 studies on the list!
The thought process is simple; too much circulating leptin saturates receptors, creating the need for increased amounts of the hormone to accomplish the same function --- telling your brain and stomach you are full. So; despite your body creating more and more leptin, it is simultaneously becoming less and less responsive to the hormone. The abstract of the November issue of Neural Regulation of Metabolism (The Leptin Resistance) said this about leptin resistance.....
"Leptin is an adipocyte-derived hormone, which contributes to the homeostatic regulation of energy balance and metabolism through humoral and neural pathways. Leptin acts on the neurons in certain brain areas such as the hypothalamus, hippocampus, and brain stem to regulate food intake, thermogenesis, energy expenditure, and homeostasis of glucose/lipid metabolism. Pathologically increased circulating leptin is a biomarker of leptin resistance, which is common in obese individuals. Leptin resistance is defined by a reduced sensitivity or a failure in response of the brain to leptin, showing a decrease in the ability of leptin to suppress appetite or enhance energy expenditure, which causes an increased food intake and finally leads to overweight, obesity, cardiovascular diseases, and other metabolic disorders."
The January 2015 issue of Metabolism (Physiology of Leptin: Energy Homeostasis, Neuroendocrine Function and Metabolism) was more blunt in their conclusions.
"Leptin is secreted by adipose tissue and regulates energy homeostasis, neuroendocrine function, metabolism, immune function and other systems through its effects on the central nervous system and peripheral tissues.... In contrast, obese individuals are resistant to leptin."
The more you eat, the more leptin your body makes to tell you that you are full. Overeat on a consistent basis and the leptin receptors become consistently saturated --- similar to what we saw in INSULIN RESISTANCE. As far as leptin goes, even though the receptors (as well as your belly) are full, your body continues to secrete leptin in order to get that message through. Again, high levels of circulating leptin means less sensitivity to leptin, meaning that you never really feel full --- or at least not for very long. But.......
What if leptin --- a hormone that has so many functions throughout your body and brain (particularly the hypothalamus, which is an important regulator of both MALE and FEMALE sex hormones as well as GROWTH HORMONE, the THYROID, and ADRENAL GLAND) that I could not possibly take time to deal with all of them --- could be externally manipulated? Maybe more importantly, what if it could be manipulated in a manner consistent with the earlier wacky-sounding quote made by Dr. Kruse --- "obesity starts in the eye"?
If you are overweight or CRAVE CARBS AND SUGAR like there's no tomorrow (or have HIGH REVERSE T3), odds are you are leptin resistant. The diet Jack recommends? PALEO, or more specifically, epi-paleo (he has a book titled Epi-Paleo Rx: The Prescription for Disease Reversal and Optimal Health). Rather than INTERMITTENTLY FASTING, which has become increasingly popular, he wants people to eat a high protein / low carb meal shortly after waking, recommending no snacking during the day. He also does not want people on his program to work out --- at all (or only after 5 pm if you feel you must). And don't eat within four hours or so of bedtime (or especially after dark). More details can be found on his page, My Leptin Prescription.
The stated purpose of his protocol is to "retrain the brain how to account for food without using the newly discovered leptin receptor." In other words, he wants to bypass the most commonly-known neuro-metabolic pathways to obesity by "using circadian rhythms, light, timing, and the stretch receptors innervated by the vagus nerve in the gut that controls our entire gut plexus." For the record, my regular readers already know a little something about the importance of the vagus nerve from my viral post on reversing sympathetic dominance (WHAT HAPPENS IN VAGUS DOESN'T STAY IN VAGUS) as well as many of my posts on GUT HEALTH.
According to Jack, the bottom line is that, "timing is more critical than any other factor in the Leptin Rx. The reason for this is we are using multiple circadian cycles to reset the hypothalamus when it is flying blind due to brain inflammation at the receptor site." There's more. In similar fashion to Tim Ferris in 4-Hour Body as well as others before him (I discuss this very thing in my earlier Vagus link), Kruse also uses cold exposure to maximize the hormonal effects of this protocol via something known as the mammalian diving response. To see details, take a look at his web page, How Does The Leptin Rx Work? or look at his numerous blog posts on the topic (something like 80 of them).
LIGHT, FREQUENCIES, EMF'S, ETC
- JACK ON FLUORIDE (one of those EVIL HALIDES)
- JACK AND DR. ANNA CABECA (OB/GYN)
- JACK ON EXTREME HEALTH RADIO
- JACK AND TRISTAN OF PRIMAL EDGE HEALTH
- JACK ON STRUCTURED WATER
Honestly, I'm still trying to sort through and make sense of what Dr. Kruse is saying. While not a believer in EVOLUTION; something he discusses quite frequently, his 'ENERGY MEDICINE' take on MITOCHONDRIAL FUNCTION / DYSFUNCTION may be much more than speculation, although I have to admit that my brain is still fermenting the idea that light is more important than food for health.
Regardless, I'll be adding this page to MY PROTOCOL designed to diminish inflammation, pain and excess weight, while maximizing health. BTW, this means my CURRENT RIVER HABIT (yeah; I'm a junkie) is a good thing after all! Oh; and if you think our site is worth passing along to those you love and value most, be sure to like, share, or follow on FACEBOOK!
A SIX MINUTE TASTE OF JACK KRUSE'S BRILLIANT MADNESS
A PAIR OF VIDEOS THAT ARE ONLY A MONTH OLD
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BIO-HACKING WITH DOCTOR JACK KRUSE
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NOURISH VERMONT (WESTON PRICE FOUNDATION)
JACK SAYS THAT LIGHT IS MORE IMPORTANT FOR HEALTH THAN FOOD!
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THE STATE OF THE AMERICAN DISEASE: MANAGEMENT -VS- CURES EXPLAINS WHY YOU ARE BIG PHARMA'S LARGEST COMMODITYRead Now
IF YOUR FAITH IS IN YOUR MEDICINE, DON'T COUNT ON EVER TRULY GETTING BETTER
Is The Pharmaceutical Industry Focused On Curing Diseases, Or Just Treating Symptoms? The title of a December, 2017 issue of Forbes
As many have already figured out, the drugs for treating diabetes and its ilk are expensive and don't work very well (HERE). Sure; they do an "OK" job of doing what they were designed to do --- lower blood sugar. But as far as doing the heavy lifting that's claimed (decreasing death, strokes, heart attacks, etc) --- it's not happening. As is often the case, THE DRUGS affect surrogate endpoints (in this case blood sugar), while morbidity and mortality run wild. What's arguably worse is that our government is subsidizing this disease on multiple fronts.
They subsidize the corn (NOT TO MENTION OTHER GRAINS) that is the source of HIGH FRUCTOSE CORN SYRUP. They are directly subsidizing the FOOD BUDGETS of the people most prone to being diagnosed (1 in 7 of those living inside our borders are on government food assistance). And they heavily subsidize corporate healthcare --- the system that's slowly taken over American medical care. After revealing that diabetes is costing over 325 billion dollars per year, the ADA went on to explain just how much of this burden is being covered by the American taxpayer. "Most of the cost for diabetes care in the U.S., 66%, is provided by government insurance (including Medicare, Medicaid, and the military). The rest is paid for by private insurance or by the uninsured."
Not only has this made healthcare as we know it --- no matter whose funding plan you promote --- completely UNSUSTAINABLE, but now we have big pharma and the medical community themselves to contend with. That's because if there is one thing we know for sure, it's that MEDICAL GUIDELINES cannot be trusted. Just how little they can be trusted can be seen in a paper published in last March's issue of the Journal of the American College of Cardiology (Trending Cardiovascular Nutrition Controversies); a paper that started out by trumpeting a fact that they should have been ashamed of.
"Contemporary guidance by the American Heart Association/American College of Cardiology (AHA/ACC), the U.S. Department of Agriculture, and the Department of Health and Human Services is issued now as food-based dietary patterns with accompanying speciﬁc nutrient recommendations."
I've already shown you how corrupt the AHA/ACC is (HERE is a great short example), but in this paper they are worse, touting SOYBEAN OIL, continuing to pan coconut oil (HERE), and even going back to ancient recommendations not to eat eggs because they are high in cholesterol (HERE). They even had the gall to quote the NLA thusly. "The National Lipid Association concluded that there is no evidence of any health beneﬁt of coconut oil" ---- this from an organization with more ties to industry than DONALD RUMSFELD, HERE).
Furthermore, the chief function of the USDA is, as stated on their website (it was first on the list), "to promote agriculture production....." Don't forget that it was the USDA who brought us one of the single most detrimental and destructive governmental recommendations this nation has ever seen; the FOOD PYRAMID. And as for DHHS, among other things, they administrate the FOOD & NUTRITION SERVICES (FOOD STAMPS) program --- a program frequently run the way a five year old would fill the grocery cart if you let them.
The point to today's post is this --- we are not quite halfway through the first month of 2019. You've already bailed on your NEW YEARS RESOLUTIONS and are realizing that this year is going to be just another rung on the ladder to unmanageable pain, weight gain, and chronic diseases (plural). But it doesn't have to be like this. Sit down today and create your own PERSONALIZED EXIT STRATEGY (I'm even giving you THIS RESOURCE completely free).
As I've mentioned numerous times, the vast majority of chronic health conditions begin with blood sugar issues. Fortunately there are a group of rogue scientists out there who have provided you with a dietary blueprint that actually makes sense for those of you coping with T2D (HERE). Just do it already! And if you have friends or loved ones who could similarly benefit, FACEBOOK is still a nice resource for reaching them.
GOT CHRONIC PAIN?
LEARN ABOUT WHAT IT TAKES TO SELF-MANAGE IT!
"There is a shortage of pain specialists with only one for every 21,000 patients. Meanwhile, untreated chronic pain impacts multiple aspects of the patient’s life, leads to depression, anxiety, irritability, emotional frustrations, social avoidance, relationship issues, loss of self esteem and lack of enjoyment of living and, occasionally, leads to suicidal ideation or attempts. Many primary care providers are comfortable treating acute pain due to its short course and usually identifiable cause, however they are much less comfortable treating chronic pain due to the myriad of complexities... such as pain without a clear etiology."
The article went on to talk about various ways of addressing chronic pain, mostly pertaining to medication --- most specifically opioids. Fast-forward six years, and we are in the throes of an OPIOID EPIDEMIC that is costing our nation over 500 billion dollars and killing nearly 50,000 people each and every year.
As I showed you (HERE), the pendulum has swung so far back the other way that many doctors are no longer prescribing opioids for fear of government retribution --- not having their claims paid, losing their licenses, or even being sent to jail. Add this to the medical community's realization that they have no real solutions to most of the chronic health issues they face all day, every day (HERE and HERE), and it's simple to see why there is a shift taking place in what constitutes the best way to deal with patients struggling with chronic pain.
Google 'chronic pain self-management,' and you'll come up with over 130 million hits. Today we are going to talk about just one --- an article from the new issue of Practical Pain Management titled Self-Management of Chronic Pain in Primary Care.
"Despite the complexity of chronic pain, at least half of all patients receive their healthcare from a primary care clinician. This raises a striking conundrum since primary care practitioners have been found to harbor negative attitudes toward patients with chronic pain, driven by a sense of insufficiency in addressing this patient complaint. To effectively address the multidimensional effects of chronic pain, patients need self-management training about behaviors, strategies, and activities that may help to control the destructive effects of pain on their quality of life."
How would you like to have a doctor that harbors "negative attitudes" towards you? The authors went on to talk about "limited options available to manage common cases of chronic pain," as well as that fact that both sides of this equation --- doctors and their patients --- feel "stuck" with their options; both groups typically and unfortunately seeing "increasing medication as the only solution." What this has done --- which, while not perfect for every person or situation --- has forced the medical profession to re-evaluate and abandon many of the practices that got us to this point.
What this really means for you --- the pain patient --- is that with doctors increasingly threatened with treatment audits and their careers being taken from them, the burden is increasingly falling on you to step up to the plate and take care of yourself (after all, today's post is about 'self care'). Since necessity is the mother of invention (or change), let's look at some of the self-management tips being promoted by these authors (an MD and clinical psychologist) for people struggling with chronic pain.
- UNDERSTAND PHYSIOLOGY: Look; if you don't have at least a cursory understanding of PHYSIOLOGY, INFLAMMATION, and CHRONIC PAIN (most people think they understand the latter two, but few actually do), getting better is going to prove tough. Since nothing makes sense, the entire situation, along with everything you try, will seem hopeless. Knowledge really is power! The authors also mentioned 'goal setting' under this bullet point. I would whole-heartedly agree since one of the most important aspects of my protocol is having patients create a PERSONALIZED EXIT STRATEGY for getting out of pain. And even though it was not mentioned, this is a good time to say something about having a support network of some kind. Online is great, but I would argue that in most cases, having someone nearby is better.
- MEDITATION & MINDFULNESS: While I'm a fan (our family watched a COOL VIDEO on meditation last evening), I have argued that "mindfulness" is all too often an intellectual-sounding, all-encompassing cop-out provided to people in chronic pain. A recommendation made by practitioners who aren't really getting to the root of things, or in many cases don't believe it's even possible to do so (HERE).
- BODYWORK: Although the authors mentioned massage, there are an almost unlimited number of forms of bodywork that can provide amazing results (HERE and HERE are two articles on this topic concerning fibromyalgia). Although there are people coping with "intractable" chronic pain (CENTRAL SENSITIZATION), I've shown you how important it is to work with these folks (HERE, HERE and HERE) because in many cases improvement is possible. My goal with my patients is not just to manage, but if possible, help provide solutions (THIS is what I'm talking about).
- STRETCHING, EXERCISE, ADL'S: I'm a huge fan of using various sorts of physical training to help get people back to performing activities of daily living without suffering every step of the way (these authors specifically mentioned stretching and a STRENGTH / CARDIOVASCULAR COMBO). Be aware, however, that in many cases, the cart gets put in front of the horse. Put simply, if people are trying to exercise or stretch areas that are microscopically 'TETHERED' by scar tissue, it has the potential to make things worse (HERE, HERE, or HERE). The more severe the case, the more true this is.
- HEALTHY EATING PLAN: Because I would argue that it's the number one key to solving SYSTEMIC INFLAMMATION (which can greatly help with either local or systemic pain), this bullet should have been number one on the list. Although I'm not quite sure where to begin since this bullet could encompass several volumes of books, THIS SHORT POST provides a starting point. It's important for the chronic pain patient to realize that inflammation always leads to fibrosis (HERE).
- SLEEP HYGIENE: Although I've talked about this in many posts, probably the most important can be found HERE.
- COUNSELING: Several things were mentioned here, including CBT, acceptance therapy, and managing setbacks. While counseling can be valuable (emphasis on "CAN"), it's important to have the right kind of counselor. Many people could benefit from seeing someone who's mostly Florence Nightingale, with a streak of Sgt Lee "Gunny" Ermey.
The most beautiful part of this plan is that much of it can be done on your own. Once your FIBROSIS / SCAR TISSUE has been dealt with, even much of the bodywork can be accomplished without professional assistance (HERE or HERE). For those of you looking to expound on this protocol, HERE it is. And while there are no fool proof methods for dealing with chronically ill or chronic pain patients, my protocol will at least get you thinking outside the box (which research is starting to show is actually inside the box even though far too many practitioners have not yet come to this realization). If you like what you're seeing or feel it deserves to be shared with struggling people, you can reach those you love and value most by liking, sharing, or following on FACEBOOK.
Dr. Schierling completed four years of Kansas State University's five-year Nutrition / Exercise Physiology Program before deciding on a career in Chiropractic. He graduated from Logan Chiropractic College in 1991, and has run a busy clinic in Mountain View, Missouri ever since. He and his wife Amy have four children (three daughters and a son).
Brain Based Therapy
Can You Help
Cardio Or Strength
Cold Laser Therapy
Death By Medicine
Degenerative Joint Disease
D's Of Chronic Pain
Evidence Based Medicine
Gluten Cross Reactivity
Ice Or Heat
Jacks Fork River
Leaky Gut Syndrome
Number One Health Problem
Platelet Rich Therapy
Post Surgical Scarring
Re Invent Yourself
Rib And Chest Pain
Scar Tissue Removal
Sleeping Pills Kill
Stay Or Go
Stretching Post Treatment
Tensegrity And Fascia
The Big Four
Thoracic Outlet Syndrome
Whole Body Vibration