USE RED / YELLOW SPICES TO HELP SOLVE INFLAMMATION
CURCUMIN / TUMERIC, BERBERE, CINNAMON, CURRY,
SAFFRON, GINGER, CUMIN, MUSTARD, BOSWELLIA........
The craziest thing is that not only is inflammation being driven by the CRAPPY DIETS eaten by most Americans, but it's being driven by the drugs we take to compensate for said diets. For instance, SUGAR DRIVES BOTH INFECTION & DYSBIOSIS. But when we go to the doctor for either, we are given ANTIBIOTICS that cause the very problem(s) we are trying to correct. This is true of any number of drugs, including many NON-ANTIBIOTICS.
My goal is to see you get healthy, get to a normal weight, get off your drugs, GET OUT OF PAIN, and get your life back. It all starts with controlling inflammation. Not with NSAIDS or CORTICOSTEROIDS mind you, but with tangible lifestyle changes. Although EXERCISE is important, it is minimally so when compared to what you put in your mouth. WHAT YOU EAT is critical --- critical for controlling inflammation and feeding a healthy (anti-inflammatory) MICROBIOME. It's one more reason why figuring out how to get more anti-inflammatory spices into your diet is important for all of us --- especially if we are dealing with CHRONIC INFLAMMATORY DEGENERATIVE DISEASES, CHRONIC PAIN, AUTOIMMUNITY, a bad case of "THE LEAKIES," or any number of others.
ANTI-INFLAMMATORY YELLOW SPICES
According to a popular online encyclopedia, "Curcumin has been shown to inhibit certain epigenetic enzymes." Why is this such a big deal? Because due to EPIGENETICS, you can no longer blame most of your health issues on your genes. Some of the 'enzymes' mentioned are responsible for seriously ugly diseases, while others are simply part of the enzymatic cascade of compounds that make up the inflammatory pathways. As far as studies are concerned, if you go to PubMed and start looking at how much peer-reviewed (MAINSTREAM) research there is on Tumeric / Curcumin, you'll be amazed. I've seen reputable sources say that there are nearly 7,000 studies touting the benefits of this yellow spice. These studies have made it into some doctor's offices.
An email I received just yesterday from the Psychiatric Times carried a PDF Power Point presentation by expert on Bipolar Disorder, Dr. James Phelps (Curcumin: New Use for an Old Spice). Phelps stated that, "Accumulating evidence implicates inflammation as a critical mediator in the pathophysiology of mood disorders." That's right folks, even Depression is considered to be "inflammatory" (HERE) along with any number of "psych" disorders. To see a list of health-related issues that have been helped by Curcumin / Tumeric, HERE it is (if the health problem is related to inflammation, I promise that someone somewhere has done or is currently doing research on it with Tumeric / Curcumin).
One more thing you need to understand about Tumeric / Curcumin is that by itself, it is not absorbed well. This means that you can eat lots and lots of top quality product and get little or no real health benefit, unless...... Just remember to use it with pepper (black pepper), as this simple spice will dramatically boost Tumeric's bioavailability. Also remember that for those of you with NIGHTSHADE SENSITIVITIES, this could present a problem (Nightshades come into play with many of these other spices as well).
Berbere is a family favorite because of my ETHIOPIAN DAUGHTERS. After making two trips to Ethiopia a bit over five years ago, I came back with a love for Ethiopian food, which is seemingly all spiced up with Berbere, giving it a unique smell and taste. The way that almost all Ethiopian food is eaten is by using Injera (a spongy sourdough pancake-like bread made from Teff --- a GLUTEN FREE grain) to mop up the vegetable and meat dishes, which are often combined. If you've never tried Ethiopian cuisine, find a restaurant and go. Or better yet, make a friend with someone from Ethiopia (they are some of the most generous, genuine, and caring people I've ever been around) that might eventually be willing to cook you an authentic meal (you buy the food).
Studies have shown that of all the spices we've mentioned thus far, Cinnamon has the highest antioxidant capacity. And in similar fashion to the other spices we've discussed today, Cinnamon has powerful anti-inflammatory properties as well, which means it can prove helpful when dealing with all sorts of health-related conditions (HERE is a list) as well as helping to lower LDL CHOLESTEROL. It's also been shown to be a powerful weapon in the war against DYSBIOSIS --- particularly against YEASTS & FUNGUS. You could certainly add a bit of Cinnamon to the drink mentioned earlier, although I would absolutely not recommend that you consume Cinnamon in THIS MANNER, as it can be hazardous to your health.
The thing about all the spices discussed today (as well as any number I did not manage to get to) is that when used with common sense and moderation, you can't really go wrong. They are spices for Pete's sake, and have been used for millennia both for making food tastier as well as for medicinal purposes. However, if you are on certain drugs --- particularly blood-thinners --- ask your doctor. Or maybe just go and check online as your doctor is not likely to know (HERE). The internet is full of great articles about the safety profiles of herbs and spices, finding the best sources for quality products, as well as recipes for using said spices, which can be a helpful part of THIS PROTOCOL.
DEATH BY SCAR TISSUE (FIBROSIS)
HOW MANY OF YOU REALIZED THAT SCAR TISSUE IS AMERICA'S #1 CAUSE OF DEATH?
Although I use the term "Scar Tissue" with my patients because it's easy for them to understand and already holds certain connotations, the medical community uses the word "Fibrosis". No matter what anyone tells you, these are the same entities (HERE). And while Scar Tissue is responsible for any number of chronic pain syndromes (HERE), how shocking would it be to learn that it is America's number one cause of death as well? Enter Dr. Thomas Wynn.
Dr. Wynn is a respected and highly decorated senior researcher for the NIH. He is a microbiologist and director of their Immunopathogenesis Section. Although his primary specialty has to do with specific inflammatory reactions caused by specific kinds of PARASITES, his real area of expertise is researching the INFLAMMATION / FIBROSIS CONNECTION. According to the NIH website, Dr Wynn's job is to figure out, "the mechanisms of fibrosis." The reason for his quest is simple --- finding a compound that can be turned into a blockbuster drug for getting rid of Scar Tissue, but sparing normal tissue. What do we currently use right now? According to Wynn, "Although fibrogenesis [the genesis or 'birth' of fibrosis] is increasingly recognized as a major cause of morbidity and mortality, there are few—if any—treatment strategies that specifically target the mechanisms of fibrosis." Why is this important to know?
When Wynn uses terms like morbidity and mortality, he means disease and death. I've already mentioned some of the heavy-hitter diseases in the top paragraph, but as for death, can Scar Tissue really cause death? Not only does it cause death, it causes it on a scale grander than you could have ever imagined. Dr. Wynn minces no words when he states via his NIH bio that, "nearly 45 percent of all deaths in the developed world are attributable to fibroproliferative disorders." In other words, out of the 2,626,418 deaths that occurred in the United States in 2014, approximately 1,180,000 were the direct result of fibrosis.
The truth is, this number is probably low since the stats are two years old. Face it; people have not gotten healthier --- less inflamed --- over the course of the past couple of years. Secondly, if you understand the basics of the process, you have a better chance of saving yourself from the possibility / probability of a long, drawn out, and miserable death. You see, it's not so much that people are, as JT sang about almost three decades ago, 'DYING YOUNG', it's that people are dying after years --- sometimes decades --- of misery and suffering. It's a scenario that drug companies absolutely love because it usually means that people are on lots of drugs for a very long time (HERE).
If you are tired of being not only being BIG PHARMA'S lackey (Webster's: "servile follower"), but their lunch ticket as well, it might be in your best interest to understand a single paragraph written under Dr. Wynn's biography. We'll get there, but first you need to grasp a couple of essentials as we move forward.
WHAT IS FIBROSIS AND HOW DOES IT KILL YOU?
"The extracellular matrix (ECM) is the non-cellular component present within all tissues and organs, and provides not only essential physical scaffolding for the cellular constituents but also initiates crucial biochemical and biomechanical cues. Although, fundamentally, the ECM is composed of water, proteins and polysaccharides [long chains of sugar molecules], each tissue has an ECM with a unique composition and topology. Moreover, the ECM is a highly dynamic structure that is constantly being remodeled. Through these physical and biochemical characteristics the ECM generates the biochemical and mechanical properties of each organ, such as its tensile and compressive strength and elasticity, and also mediates protection by a buffering action that maintains extracellular homeostasis and water retention. Acute injury activates the fibrogenic machinery and induces wound healing.
In a healthy tissue, once the wound has been repopulated [with collagen and ECM], strict feedback mechanisms are initiated that ensure restoration of tissue. Under extreme conditions, such as repeated injury, these aberrant conditions promote chronic vascular remodeling and enhanced ECM crosslinking that eventually leads to aberrant fibrosis and an inability of the tissue to heal properly. This aberrant wound healing scenario is characterized by the altered mechanical stability and reduced elasticity that is typical of scarred tissue. In extreme cases, a chronic wound can also promote a tumor."
Did you catch all this? Scar Tissue is bad news that can lead not only to chronic pain, but to sickness, disease, and death. It does this by creating a microscopically "crosslinked" HAIRBALL-LIKE WEB OR NET of aberrant collagen and ECM. This web not only causes mechanical restriction, but THICKENED TISSUE IS WEAK as well as hypoxic, effectively acting to choke off the blood supply via entangling and then strangling the capillary beds, which causes low OXYGEN levels and pain, as well as an impaired ability to heal. The important thing to remember is that this process can occur anywhere in your body, including organs. But all of this begs yet another question --- what sort of "injury" or "insult" causes said fibrosis?
In his NIH bio, Wynn nibbles around the edges of this question by revealing that said "injuries" can occur in a variety of manner. "Fibrotic tissue remodeling is the final common pathological outcome of many chronic inflammatory and infectious diseases." In his scientific paper he goes on to spell it out in no uncertain terms. "Fibrosis is the end result of chronic inflammatory reactions induced by a variety of stimuli including persistent infections, autoimmune reactions, allergic responses, chemical insults, radiation, and tissue injury". In other words, his list covers the brunt of the THREE BULLET POINTS I dealt with recently. Of these, the easiest to control comes from the "chemical insults". The truth is, the average American is chemically insulting their body on an almost hourly basis via the garbage we continue shoving into our collective pie holes --- especially this time of year as the HOLIDAY SEASON is upon us.
The secret to stopping fibrosis is stopping inflammation. Wynn tells us why in his NIH bio. "When the wound-healing response is well organized and controlled, the inflammatory response resolves quickly, and normal tissue architecture is restored. However, if the wound-healing response is chronic or becomes dysregulated, it can lead to the development of pathological fibrosis or scarring, impairing normal tissue function and ultimately leading to organ failure and death." Death? Because the first step in "Death by Fibrosis" is the creation of an inflammatory response, the next question that needs answered is.....
WHAT IS INFLAMMATION?
Inflammation is difficult to address properly because it is needed for your body's normal, everyday, healing processes ("synthesis of extracellular matrix components like collagen is an indispensable and, typically, reversible part of all wound-healing responses"), but these processes can, and often do go plumb haywire ("normal tissue repair can evolve into a progressively irreversible fibrotic response if the tissue injury is severe or repetitive or if the wound-healing response itself becomes dysregulated"). Which brings us to still another question; how does the healing process get derailed to the point where it becomes pathological? Much of it revolves around the fact that everything you do is either driving or squelching normal FIBROBLASTIC ACTIVITY within the body.
WHEN INFLAMMATION BECOMES A PATHOLOGICAL PROCESS
CAN FIBROSIS BE REVERSED?
Because a pathological fibrotic process is, at least in most cases, a normal healing process gone out of control, stopping it can prove difficult. Everything that might be driving the process of inflammation must be addressed. But clicking the link shows that the medical community is, BY AND LARGE, not interested in dealing with inflammation's number one cause -- poor diets. They are far more interested in dealing with inflammation via drugs, or via some sort of yet-to-be-discovered drug that can break down Scar Tissue, while leaving the healthy tissue untouched. Unfortunately, Dr. Wynn reveals in his NIH bio that so far, this has proved to be a pipe dream. "Few—if any—treatment strategies specifically target the mechanisms of fibrosis." So what has the medical community done? They've simply moved upstream from dealing with fibrosis to deal with the cause of fibrosis --- inflammation. The conundrum here is similar to that seen in fibrosis --- that inflammation is a vital part of normal immune system function and intercellular communication, as well as being intimately involved in your body's minute-by-minute healing processes.
Don't get me wrong; suppressing various inflammation pathways is often quite effective --- at least as far as short term symptomatic relief is concerned (NSAIDS for instance). The problem is that the drugs that do this best have side effects that are often MUCH WORSE AND MUCH MORE FREQUENT than we have been led to believe by our doctors or the TV COMMERCIALS we all seem to trust so much. These drugs have an accumulative effect on the various cells, organs, and tissues in the body (particularly the heart, kidneys, and liver). And when we move up to the heavy-hitters that actually suppress the immune system itself, things have the potential to get downright ugly.
These "uglier" drugs include CORTICOSTEROIDS and the recycled chemotherapy drugs from the 1960's (TNF-α Inhibitors) whose generic names end with "mab" such as Humira or Remicade, or etanercept (Enbrel). I would never argue that this class of drugs does not work; they often work like magic. Just understand that their side effect profile can be rather severe due to the fact they are strenuously and aggressively suppressing one's own immune system (Solomon's study in Arthritis and Rhematology stated that, "there is concern that therapy with TNF inhibitors might predispose patients to adverse effects related to impaired immunity, including an increased incidence of infections and/or cancer." Here's my simplest take on the whole mess.
If you haven't already done it, change the way you eat. But please hear what I am saying. The point is not to suggest that AN ANTI-INFLAMMATORY DIET is going to solve all cases of fibrosis. It's to let you know that because it has the potential to dramatically aid most of you who try it in one way or another (it's the lowest of the low-hanging fruit), it's never a bad option for whatever ails you. But remember; diet is not the only way to get inflammation under control --- not by a long shot.
I've shown you SOME OF THE MIRACLES that can occur when people with chronic diseases and autoimmunity realize that they can actually start blocking the process of fibrosis by inhibiting inflammation at its source(s) (HERE). The end result is that they not only feel better, their body starts to work more like it should again. And while it might be tough (even impossible) to reverse fibrosis in say the heart, it is much easier to reverse the process in the musculoskeletal system. Because so many painful conditions have FIBROTIC FASCIA or FIBROTIC TENDONS as part of their pathology, dealing with them IN A MECHANICAL FASHION can often prove EXTREMELY EFFECTIVE. Part of this is because as opposed to organs, they are usually SUPERFICIAL ENOUGH to be accessible enough to treat.
REVISITING THE INFLAMMATION / FIBROSIS (SCAR TISSUE) CONNECTION AS THE SOLUTION TO CHRONIC PAIN AND CHRONIC DISEASERead Now
FOR THOSE STRUGGLING WITH CHRONIC PAIN AND / OR CHRONIC DISEASE
INFLAMMATION & FIBROSIS
THE FORMER ALWAYS LEADS TO THE LATER
"Nearly 45% of all deaths in the developed world are attributed to some type of chronic fibroproliferative disease [fibrosis]. Fibroproliferative diseases, including pulmonary fibrosis, systemic sclerosis, liver cirrhosis, cardiovascular disease, progressive kidney disease, and macular degeneration, are a leading cause of morbidity and mortality and can affect all tissues and organ systems. Despite its enormous impact on human health, there are currently no approved treatments that directly target the mechanism(s) of fibrosis. Damage to tissues can result from various acute or chronic stimuli, including infections, autoimmune reactions, and mechanical injury. Although initially beneficial, the healing process becomes pathogenic if it continues unchecked, resulting in substantial formation of permanent scar tissue. Pathogenic fibrosis typically results from chronic inflammatory reactions — defined as responses that persist for several weeks or months and in which inflammation, tissue destruction, and repair processes occur simultaneously." Dr. Thomas Wynn from The Journal of Clinical Investigation (Common and Unique Mechanisms Regulate Fibrosis in Various Fibroproliferative Diseases). The good news for those of you struggling with chronic pain or chronic illness is that the author goes on to say that there is an, "emerging paradigm that fibrosis is a reversible process."
- MECHANICAL CAUSES: This category contains things like POOR POSTURE, FORWARD HEAD POSTURE, WHIPLASH, SPORTS INJURIES, or many of the items found HERE.
- CHEMICAL CAUSES: This could be anything from exposure to chemicals, herbicides, pesticides, BPA, MEDICATIONS (even OTC medications), cleaning products / beauty products / pesticides / herbicides (HERE), CIGARETTES, lead, MERCURY, ALUMINUM, TOO MUCH ESTROGEN, GLUTEN or similar food sensitivities, along with too many others to even contemplate.
- STRESS: Stress can come in many forms. It can be either mechanical or chemical, but it can also be emotional. It can be dietary as well (usually ADDICTIONS to JUNK FOOD and CARBS). Stress can lead to ADRENAL FATIGUE, which can wind up throwing people into CENTRAL SENSITIZATION (FIBROMYALGIA is in this category). The end result is almost always some sort of SYMPATHETIC DOMINANCE.
Inflammation is the name given to the hundreds of chemical mediators that act as the body's cellular messengers for the purpose of healing damaged tissue. The body doesn't really care how the tissue injury occurred (or in many chronic cases, is ongoing), but will do what it takes to heal it by manufacturing and releasing the chemicals (inflammation) to do so. The thing to remember here is that while a certain amount of inflammation is needed, anything over that amount causes a wide variety of problems. Although the list of potential problems caused by unbridled inflammation are virtually limitless, one sticks out above the rest due to it's penchant for causing pain, sickness, disability, and death, all on a grand scale (the quote at the top shows that it causes almost half of all deaths). We are talking about Fibrosis.
I have shown you any number of times (HERE is the best example), that too much or too many of the chemical mediators needed to heal damaged tissue (INFLAMMATION) always leads to formation of the Scar Tissue that the medical community refers to as "FIBROSIS". Thus, it should be fairly clear that we are not only talking here about the SCAR TISSUE that I deal with all day long in my clinic as far as solving CHRONIC PAIN SYNDROMES is concerned. We are talking about the microscopic adhesions that form the foundation of virtually every single disease process you can name (and hundreds more you can't).
Bottom line, inflammation kills via a process of your body weaving microscopic webs that ensnare and entangle cells, tissues, and organs, preventing them from moving, gliding, or functioning biochemically as they should. For those of you who think I'm "whistlin Dixie," this post is for you. Follow along as I prove this to you this from the peer-reviewed literature of the past two or three months (all quotes are cherry-picked due to restraints on time and space). Which is exactly why you should be living an ANTI-INFLAMMATORY LIFESTYLE --- even if you are healthy. Especially if you are healthy! Taking your health for granted because you are free of symptoms today, can inhibit your body's ability to fight off or heal whatever life decides to throw at it tomorrow.
INFLAMMATION ALWAYS LEADS TO FIBROSIS
THE PEER-REVIEWED RESEARCH FROM THE PAST COUPLE OF MONTHS
WEED, INFLAMMATION, & FIBROSIS: The November issue of the Journal of the Federation of American Societies for Experimental Biology carried a fascinating study called Cannabinoids, Inflammation, and Fibrosis, which compared the anti-inflammatory abilities of NSAIDS to WEED. The study revealed that, "Cannabinoids apparently act on inflammation through mechanisms different from those of agents such as nonsteroidal anti-inflammatory drugs (NSAIDs). As a class, the cannabinoids are generally free from the adverse effects associated with NSAIDs. Their clinical development thus provides a new approach to treatment of diseases characterized by acute and chronic inflammation and fibrosis. Several cannabinoids may be considered candidates for development as anti-inflammatory and antifibrotic agents. Of special interest is their possible use for treatment of chronic inflammation, a major unmet medical need." As you wind your way through today's post, pay close attention to how many mainstream journals are running trials on various herbs, plants, and botanicals as alternates to pharmaceuticals.
GENERALIZED INFLAMMATION, FIBROSIS AND DISEASE: Less than a month ago, Fundamental & Clinical Pharmacology published a study called Purinergic Receptors: New Targets for the Treatment of Gout and Fibrosis. This study showed that, "Extracellular ATP [energy] release by activated or necrotic [dead or dying] cells may activate various purigenic receptors and especially P2X7R. P2X7R is known to regulate the activation of the NLRP3 inflammasome, which permit the release of IL-1β, a potent pro-inflammatory cytokine. The P2X7R/NLRP3 pathway is involved in many inflammatory diseases, such as gout, and in fibrosis diseases associated with inflammatory process, liver or lung fibrosis." Bottom line, researchers are looking for various compounds to be patented as blockers of this pathway that could be sold for huge profit at drugstores.
INFLAMMATORY BOWEL DISEASE: The October issue of Gastroenterology (Mechanisms, Management, and Treatment of Fibrosis in Patients with Inflammatory Bowel Diseases) concluded that, "In the last 10 years, we have learned much about the pathogenesis, diagnosis, and management of intestinal fibrosis in patients with inflammatory bowel diseases (IBD). Just a decade ago, intestinal strictures were considered to be an inevitable consequence of long-term inflammation... IBD-associated fibrosis was seen as an irreversible process that frequently led to intestinal obstructions requiring surgical intervention." Unfortunately, even though things are improving, this sort of fibrosis is still largely irreversible via medications (HERE). Case in point, a study from October's issue of the American Journal of Physiology Gastroenterology & Liver Physiology (Hydroxylases Regulate Intestinal Fibrosis....) which concluded, "Fibrosis is a complication of chronic inflammatory disorders such as inflammatory bowel disease (IBD), a condition which has limited therapeutic options." There were also several studies discussing various compounds to block the body's inflammatory pathways. Last month's issue of Crohn's & Colitis (Genetic Deletion of Tissue Inhibitor of TIMP-1 Alters Inflammation and Attenuates Fibrosis) revealed that, "Increased levels of tissue inhibitor (TIMP-1) have been detected in both inflammatory and fibrotic lesions in Crohn's disease.... Chronic inflammation and fibrosis were associated with an increase in TIMP-1."
ABDOMINAL ADHESIONS: Pirfenidone is an anti-fibrotic drug that works by down-regulating the production of growth factors and pro-collagen substances. In a study from August's issue of the Journal of Investigative Surgery (Effect of Pirfenidone on Vascular Proliferation, Inflammation and Fibrosis in an Abdominal Adhesion Rat Model), the authors started out by subjecting three groups of female rats to a model that is known to create abdominal adhesions. The rats were treated in various ways by the drug Pirfenidone. Not that I'm really interested in this drug, but we learned that, "Intraperitoneal administration of pirfenidone compared to oral administration was more effective in reducing tissue levels of inflammatory markers." Why did this matter to the authors? Because Inflammation always leads to Fibrosis! "Pirfenidone is an effective agent on the prevention of postoperative vascular proliferation, inflammation and fibrosis in scarred tissue." By the way, I get lots of questions about POST-SURGICAL SCAR TISSUE. The real question that needs to be answered as related to this particular bullet is whether it's in the ABDOMINAL WALL OR ABDOMINAL CAVITY.
SYSTEMIC SCLEROSIS A.K.A SCLERODERMA: Scleroderma is one of the Autoimmune Diseases my sister cured herself of (along with Rheumatoid Arthritis, something similar to Lupus, and two others --- HERE). It is an all over fibrosis, that causes a wide variety of pain syndromes and organ problems. Last month's issue of the American Journal of Physiology (Transforming Growth Factor β... Inflammation and Pulmonary Fibrosis) concluded that, "TGF-β signaling ["inflammation"] affects pulmonary abnormalities... that manifests three important lung pathological features: fibrosis, inflammation, and vascular remodeling." A study from the October issue of the Journal of Clinical and Experimental Rheumatology (Th17 Cells and IL-17 Promote the Skin and Lung Inflammation and Fibrosis....) concluded that the TH-17 SYSTEM, "participates in the pathogenesis of skin and lung fibrosis by enhancing fibroblast proliferation and cytokine [inflammation] production." HERE is information about fibroblasts (scar tissue / collagen forming cells) as related to this subject. Not surprisingly, two weeks ago the journal Arthritis Research & Therapy (Intestinal Dysbiosis is Common in Systemic Sclerosis....) related it all to GUT HEALTH and something called DYSBIOSIS. "Recent evidence suggests altered microbiota composition, commonly referred to as dysbiosis, has been shown to induce and modulate systemic inflammation in rheumatic diseases and immune-mediated inflammatory diseases. In the field of rheumatology, intestinal dysbiosis has been associated with rheumatoid arthritis, systemic lupus erythematosus, Sjögren’s syndrome and ankylosing spondylitis. In Scleroderma, small intestinal bacterial overgrowth [SIBO] is a well-described complication associated with GI dysmotility, GI discomfort, and malnutrition. Dysbiosis was more severe in patients with elevated serum markers of inflammation. We suggest that an aberration of the intestinal microbiota may contribute to the development of systemic inflammation and fibrosis." October's issue of the Journal of Investigative Dermatology (Glycyrrhizin Ameliorates Fibrosis, Vasculopathy, and Inflammation...) looked at the effects of licorice root as a solution to this problem. "Systemic sclerosis is a multisystem inflammatory and vascular disease resulting in extensive tissue fibrosis. Glycyrrhizin, clinically used for chronic hepatic diseases and itching dermatitis, modulates the pathological processes of inflammation, vasculopathy, and fibrosis in human diseases. These results indicate that glycyrrhizin ameliorates dermal fibrosis through the inhibition of fibroblast activation [fibrosis]."
METABOLIC SYNDROME: Metabolic Syndrome, more commonly referred to as Cardiometabolic Syndrome or Pre-Diabetes, is absurdly out of control here in America (HERE). Characterized by having two of seven distinct entities (HERE), this problem potentially affects all organ systems. The September issue of Obesity Science & Practice (Highly Purified Eicosapentaenoic Acid Ameliorates Cardiac Injury and Adipose Tissue Inflammation...) showed how PFGO (my clinic's number one selling product) can prevent both inflammation and fibrosis. "The present study has here shown that EPA attenuated adipocyte hypertrophy [fat cell growth] and inflammation in visceral fat [fat around organs] as well as fibrosis, diastolic dysfunction, oxidative stress and inflammation in obese rats. The beneficial effects of EPA on the heart are likely due to reduced cardiac oxidative stress and inflammation." The September issue of the Canadian Journal of Physiology and Pharmacology dealt with the DIABETES DRUG Gemigliptin, saying that it, "ameliorated inflammation and fibrosis through suppression of oxidative stress." In a similar study from October's issue of Medical Hypothesis, a drug originally made from flowers (Colchicine) specifically for people who don't tolerate NSAIDS, was tested on people with Metabolic Syndrome. Authors concluded that, "it appears to exert an anti-inflammatory, anti-fibrotic, and immuno-modulatory effect". How effective are these and similar drugs at actually solving Metabolic Syndrome? Despite what these last two studies are saying, unfortunately not too (see previous link).
FULL-BLOWN DIABETES: Truth be known, for all intents and purposes, if you have pre-diabetes you are a functional diabetic. So it's no surprise to see that this month's issue of Pharmacology and Therapeutics dealt with the issue in a study called Cardiac Oxidative Stress in Diabetes: Mechanisms.... What is the mechanism for developing diabetes? In a study that addresses AGES, Vascular Complications of Diabetes....., we saw yet again that, "cardiac oxidative stress is associated with increased cardiac fibrosis and hypertrophy, and reduced cardiac performance and contractility, leading to severe cardiac dysfunction and potentially fatal cardiac events. It occurs under conditions of excessive synthesis of reactive oxygen species [FREE RADICALS]. The ensuing activation produces inflammation, fibrosis, and further oxidative stress, which itself causes DNA and membrane damage." The October issue of Biomedicine & Pharmacotherapy published as study showing that one way to halt this damage was via a Chinese herb known as Dendrobium Officinale Kimura. The authors concluded that this herb, "possesses cardioprotective potential against diabetic cardiomyopathy, which may be due to the inhibition of oxidative stress, cardiac lipid accumulation, pro-inflammatory cytokines and cardiac fibrosis." Needless to say, there were several similar studies talking about inflammation and fibrosis the liver, lungs, and other organs as related to diabetes (HERE is my article on Fascia as related to Diabetes).
HEART: Bear in mind that a myocardial infarction (MI) is the medical way of saying "Heart Attack". Last month's issue of Arthritis Care and Research (Magnetic Resonance-Detected Myocardial Inflammation and Fibrosis in Rheumatoid Arthritis....) concluded that, "Myocardial dysfunction and heart failure are increased in rheumatoid arthritis (RA). These data suggest that MR findings indicating myocardial inflammation/fibrosis are correlated with RA disease activity and alterations in myocardial structure known to associate with precede clinical heart failure." The November issue of Inflammation published a study on inflammation and fibrosis as it relates to heart attacks, saying that, "Inflammation has been implicated in myocardial infarction. MDM2 associates with nuclear factor-κB (NF-κB)-mediated inflammation. MDM2 inhibition reduced cardiac dysfunction and fibrosis after MI." Just a couple of weeks ago, the British Journal of Pharmacology published a similar study called SITA Reduces Inflammation, Fibrosis and Preserves Diastolic Function...... In this study we saw that, "SITA positively interferes with inflammatory-related endothelial dysfunction and fibrosis... Myocardial levels of pro-inflammatory TNF-α, IL-6 and MCP-1 were reduced. The markers of oxidative and nitrosative stress were decreased. Moreover, increase of collagen deposition and activation of pro-fibrotic signaling, that lead to elevated myocardial stiffness, were attenuated by SITA." Last month's issue of the Journal of Biochemical and Molecular Toxicology carried research that dealt with a substance called Galectin (a group of proteins characterized by the way they bind to sugar) as it relates to monocrotaline (a toxic plant constituent that poisons livestock and humans through the ingestion of contaminated grains and other foods, which causes an array of heart problems). "Galectin-3 (Gal-3) plays a critical role in vascular inflammation and fibrosis. The role of TGF-β1 in mediating pulmonary vascular fibrosis is well documented; thus, we suspected that Gal-3 could be an important factor in TGF-β1-induced fibrosis in pulmonary fibroblasts." What are FIBROBLASTS? Click for the answer (blasts are "builders," thus fibroblasts build fibrous tissue. This is fine and is necessary for healing as long as there is not too much inflammation in the system, which always ends up causing fibrosis.
LUNGS / ASTHMA: This month's issue of the American Journal of Respiratory, Cell, and Molecular Biology published a study about the way that inflammation causes fibrosis after chronic UPPER RESPIRATORY INFECTIONS. "NFkB is a major controller of pulmonary fibrosis, a finding that has potentially important relevance to airway remodeling produced by repetitive viral infections" This is a huge deal once you understand how important NFkB really is. According to Wikipedia it's, "a protein complex that controls transcription of DNA, cytokine production and cell survival. NF-κB is found in almost all animal cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals, heavy metals, ultraviolet irradiation, oxidized LDL, and bacterial or viral antigens. NF-κB plays a key role in regulating the immune response to infection." Another study from the same issue of the same journal looked at similar compounds concluding, "that the redistribution of SOD3 as a result of the R213G SNP protects mice from bleomycin-induced fibrosis and secondary pulmonary hypertension by improved resolution of alveolar inflammation." Interestingly enough, when researching this post I found numerous studies on the anti-inflammatory herb curcumin. Last month's issue of Inflammation carried a study which concluded, "Pulmonary fibrosis is associated with irreversible, or partially reversible, airflow obstruction and ultimately unresponsiveness to asthma therapies such as corticosteroids. Intranasal curcumin, an anti-inflammatory molecule, has been found effective in allergic asthma." Wow! Why has it been effective? "Curcumin significantly inhibited airway inflammation and pulmonary fibrosis. These results suggest that intranasal curcumin regulates airway inflammation and remodeling in chronic asthma." Another study with curcumin, this one from the November issue of Pharmacological Research (Curcumin Use in Pulmonary Diseases) revealed that, "Over the last several decades, the therapeutic properties of curcumin have slowly been elucidated. It has been shown that curcumin regulates transcription factors (NF-kB), cytokines (IL6, TNF-alpha), adhesion molecules (ICAM-1), and enzymes (MMPs) that play a major role in inflammation and cancerogenesis. These effects may be relevant for several pulmonary diseases that are characterized by abnormal inflammatory responses, such as asthma or chronic obstructive pulmonary disease, acute respiratory distress syndrome, pulmonary fibrosis, and acute lung injury. Furthermore, some preliminary evidence suggests that curcumin may have a role in the treatment of lung cancer." speaking of Cancer as related to fibrosis (we already know Cancer is considered an "INFLAMMATORY DISEASE")........
CANCER: Because CANCER is running rampant in the United States, it pays to understand its link to inflammation and fibrosis. The November issue of Cancer Letters revealed how intimate the relationship via its title, G Protein-Coupled Estrogen Receptor Deficiency Accelerates Liver Tumorigenesis by Enhancing Inflammation and Fibrosis. Earlier this year, the Soviet journal Molekuliarnaia Biologiia (S100A4, A Link Between Metastasis and Inflammation) concluded that, "Chronic inflammation is acknowledged to be a hallmark of neoplasia - both in cancer initiation and metastasis progression [spreading to other areas within the body]. Here we summarise data suggesting that S100A4 is а trigger of the cascade events that establish an inflammatory milieu and provide a potent flame for primary tumour growth and especially for its metastatic dissemination. This protein is also involved in the pathogenesis of autoimmune diseases, fibrosis, and other disorders. Therefore, we suggest that S100A4 is a common pro-inflammatory factor involved in the pathogenesis of diverse diseases including cancer." This next study looks at the whole inflammation / fibrosis / cancer link as it pertains to a tropical flowering plant called Plumbago Genus. October's issue of Oncotarget revealed that, "Results shown that plumbagin increased survival rate, reduced liver congestion and inflammation, and remarkably diminished liver fibrosis and inflammation in the chronic liver injury model. Plumbagin may be a powerful drug candidate to protect the liver from acute and chronic damage by inhibiting inflammation and collagen production [fibrosis]."
OBESITY: OBESITY is yet another of those common health issues that falls under the category of "Inflammatory". Last month's issue of Scientific Reports (A High-Fat High-Sucrose Diet Rapidly Alters Muscle Integrity, Inflammation and Gut Microbiota...) concluded something we are already largely (no pun intended) aware of (HERE), "Abnormal muscle repair is defined by sustained muscle fibrosis, which interferes with the appropriate healing of muscle tissue. We show that intramuscular fat, fibrosis, and the number of pro-inflammatory cells increased by day three and was sustained across twenty eight days of high-fat high-sugar feeding compared to control-diet animals. This muscle wasting includes both intramuscular adipose [fat] accumulation and muscle fibrosis, and moreover, intramuscular fat and inflammatory cell accumulation is associated with the onset of insulin resistance. Adipose tissue lipid storage is altered with obesity, and adipose tissue fibrosis is considered a hallmark of metabolic alterations. Moreover, insulin resistance is reported to be a consequence of human adipose tissue fibrosis." Did you catch that? Read it again carefully if you didn't. Although intimately related to each other, Insulin Resistance occurs long before diabetes or even pre-diabetes (HERE). The important point to remember here is that not all fat is created equal (HERE). Because dietary fat can either drive inflammation or squelch inflammation, it would be interesting to see this study repeated with a wide variety of dietary fats. DO NOT BE AFRAID OF DIETARY FAT --- make fat your friend!
POST-SURGICAL DISC PROBLEMS: Earlier this year, an issue of the Annals of Neuroscience published a study called Experimental Model of Intervertebral Disk Mediated Postoperative Epidural Fibrosis. In this study, we learned that, "It is known that scar tissue is always formed as a physiological reaction to any surgical intervention in response to the surgical trauma. However, the intensity and duration of this process may be different and depends on many factors. Postoperative epidural fibrosis after lumbar discectomy is its most common and at the same time controversial issue. Epidural fibrosis has been described in 24-38% of patients with failed back surgery syndrome. Re-operations, aimed at scar resection are difficult and ineffective and have higher risk of complications. Data analysis shows that there are different inflammatory substances involved in formation of scar adhesions after spinal surgery, and various degrees of peridural fibrosis are detected. In addition, it is known that the tissue of degenerated nucleus pulposus can maintain a state of chronic inflammation in spinal canal and nerve roots, membranes of spinal cord and epidural adipose tissue, and it causes reactive changes therein which leads to development of scar adhesions [fibrosis]. Intervertebral disk tissue is avascular; it is formed separately from the immune system and possesses antigenic properties. The destruction of intervertebral cartilage triggers the cascade mechanism of cellular immunity, which leads to formation of anti-disk antibodies. Antigen-antibody complexes stimulate the production of pro-inflammatory substances (cytokines, prostaglandin) and proteolytic enzymes (proteases, collagenases) that induces progressive degeneration of the intervertebral disk and adhesions development with other structures of the spinal canal." Pay attention because in the same way that tissue from INJURED BRAIN is attacked as "foreign" once it's displaced into the bloodstream, so can the disc's inner jelly (NUCLEUS) be likewise attacked. In either case, the result is an AUTOIMMUNE REACTION. This is why the protocol I will show you at the end of the post can dramatically and often times rapidly help many of you struggling with disc issues.
SPINAL CORD INJURY: You need to know a bit about GLIAL CELLS for this bullet. A month ago today, Brain Research carried a study called Curcumin Inhibits Glial Scar Formation by Suppressing... Inflammation and Fibrosis. The authors concluded, "Spinal cord injury leads to glial scar formation by astrocytes, which severely hinders neural regeneration. Curcumin can inhibit glial scar formation. We found that curcumin and... could inhibit astrocyte activation through suppressing NF-κb signaling pathway, which led to down-regulate the expression of chemokines MCP-1, RANTES and CXCL10 [inflammation], thus reducing the inflammation in the glial scar. Curcumin reduced α-SMA (an important symbol of fibrosis) and inhibited glial scar formation by regulating fibrosis. This study confirmed that curcumin could reduce the expression of intracellular and extracellular glial scar components through dual-target regulating of both inflammation and fibrosis." Looks to me like you should be thinking about adding "The Yellows" (circumin, boswellia, tumeric, etc) to your nutritional regimen.
SCOLIOSIS: This amazing study done on fish (Unilateral Perivertebral Fibrosis Associated with Lordosis, Kyphosis and Scoliosis (LKS) in Farmed Chinook Salmon...) was carried in the October issue of Diseases of Aquatic Organisms. "Radiography and histology were used to quantify lordosis, kyphosis and scoliosis (LKS) and perivertebral fibrosis... The most frequent histological finding was unilateral perivertebral fibrosis that often resulted in separation or loss of myocytes [muscle cells]. Histology of other tissues revealed multifocal inflammation within muscle, peripheral connective tissues and myocardium. In this study, LKS was consistently and significantly associated with perivertebral fibrosis, suggesting that perivertebral fibrosis is an important process in the development of LKS." This is not surprising considering that farmed salmon is raised in warm waters and fed grain (both skew the fatty acid profile away from OMEGA THREE), while wild cold-water salmon are loaded with naturally occurring (anti-inflammatory) Omega-3 fatty acids. Cold water is what causes high Ω-3 fatty acid profiles. Could something similar be occurring in humans? Probably on some level. Considering that the average American is consuming about 1/30th the amount of Ω-3's they should be, it makes sense.
SHOULDER INJURIES: Less than two weeks ago, the Journal of Orthopedic Surgery and Research carried a study on shoulder problems. In it they concluded, "We hypothesized that a rat shoulder contracture model using immobilization would be capable of producing effects on the glenohumeral joint similar to those seen in patients with frozen shoulder. Infiltration of inflammatory cells was found in the synovial tissue until 2 weeks after immobilization. However, inflammatory cells were diminished and fibrosis was dominantly observed in the synovium and subsynovial tissue 3 weeks after immobilization. Our study demonstrated that a rat frozen shoulder model using immobilization generates the pathophysiologic process of inflammation leading to fibrosis on the glenohumeral joint similar to that seen in patients with frozen shoulder." Although I treat tons of SHOULDER PROBLEMS very successfully, I don't have the rapid (often times instant) results with frozen shoulders. By the way, the "official" name of Frozen Shoulder Syndrome is Adhesive (adhesion = fibrosis) Capsulitis (itis = inflammation). Thus, it's fibrotic change occurring deep down in the joint's ligamentous capsule.
MICROBIOME MODULATES BOTH INFLAMMATION AND FIBROSIS: On Pearl Harbor Day, the official journal of the American Heart Association (Circulation) carried a study called High Fibre Diet and Acetate Supplementation Change the Gut Microbiota and Prevent the Development of Hypertension and Heart Failure. The authors concluded that, "Dietary intake of fruit and vegetables is associated with lower incidence of hypertension, but the mechanisms involved have not been elucidated. We found that high consumption of fibre modified the gut microbiota populations and increased the abundance of acetate-producing bacteria. Acetate had similar effects and also markedly reduced renal fibrosis. Transcriptome analyses showed that the protective effects of high fibre and acetate were accompanied by the down-regulation of cardiac and renal Egr1, a master cardiovascular regulator involved in cardiac hypertrophy, cardiorenal fibrosis and inflammation." If you are interested in the relationship of one's MICROBIOME to inflammatory and autoimmune illnesses, as well as chronic pain, just follow the link.
BPA CAUSES BOTH INFLAMMATION AND FIBROSIS: BPA is a highly toxic chemical found in plastics, similar synthetics, the lining of food cans (huh?), and any number of other sources. Trust me when I tell you it's bad news (among other things, it's a hardcore XENOESTROGEN). This month's International Journal of Experimental Pathology confirmed this with a study called Inflammation, Oxidative Stress and Apoptosis Cascade Implication in Bisphenol A-induced Liver Fibrosis.... Authors concluded that, "Bisphenol A (BPA) is a key monomer in the production of plastics. Inflammation and oxidative stress are closely linked with liver fibrosis... In addition, there was inflammation, oxidative stress, reduction in glutathione [a powerful antioxidant] and apoptosis [cell death]. Thus, the mechanism by which BPA induced liver fibrosis seems to be related to stimulation of the inflammatory response..." This, folks, is downright freaky!
SLEEP APNEA: Most commonly the result of obesity, SLEEP APNEA is in the news again; this time in a study published in the November issue of the Journal of Biomedical Research (Chronic Intermittent Hypoxia Induces Cardiac Inflammation and Dysfunction...). The authors determined that, "Chronic intermittent hypoxia is considered to play an important role in cardiovascular pathogenesis during the development of sleep apnea. Chronic intermittent hypoxia disrupted normal arrangement of cardiac fibers and increased Sirius stained collagen fibers [fibrosis]. The expression levels of hypoxia induced factor (HIF)-1α, NF-kB, IL-6, and matrix metallopeptidase 2 (MMP-2) [inflammation] were significantly increased in the hearts exposed to chronic intermittent hypoxia. In conclusion, the left ventricular function was adversely affected by chronic intermittent hypoxia, which is associated with increased expression of HIF-1α and NF-kB signaling molecules and development of cardiac inflammation, apoptosis and fibrosis."
KIDNEY INJURY AND / OR KIDNEY DISEASE: A few months ago, the journal Mediators of Inflammation published a study called TGF-β1/Smads and miR-21 in Renal Fibrosis and Inflammation. For the record, both the substances in the title would be classified as "inflammation". This study did as good a job as I've seen of showing that fibrosis is always the end-product of inflammation, and that it can be deadly. "A link between renal inflammation and fibrosis is well established. Renal fibrosis, irrespective of its etiology, is a final common stage of almost all chronic kidney diseases. Increased apoptosis [cell death] and inflammatory cell infiltration characterize the injured kidney. The importance of fibrotic diseases rises in a global awareness, as approximately 45% of all deaths in the Western world are related to various forms of fibrosis. Fibrosis develops in response to injury, when the normal wound-healing process is dysregulated and pathologically sustained. Excessive deposition of extracellular matrix (ECM) is a hallmark of all fibrotic diseases as ECM accumulation replaces functional tissue with a scar and this process alters organ physiological function and leads to its failure." I could have come up with dozens of other studies in this area of the kidneys, but we'll call it good with this one.
LIVER: Honestly, there were so many (hundreds) of studies linking Inflammation to Fibrosis in the liver, I am barely touching on this bullet considering I could have written volumes from what came out in the past weeks alone. Last month, the World Journal of Gastroenterology published a study that said, "Non-alcoholic fatty liver disease (NAFLD) is one of the most common comorbidities associated with overweight and metabolic syndrome. Importantly, NAFLD is one of its most dangerous complications because it can lead to severe liver pathologies, including fibrosis. The major risk factor that defines the prognosis of all chronic liver disease, including NAFLD, is fibrosis. It is becoming increasingly clear that these diseases are the result of the same underlying pathophysiological processes associated with metabolic syndrome, such as insulin resistance, chronic systemic inflammation and dyslipidemia." The February 2017 issue of Mathematical Biosciences and Engineering (yes, it's already out) stated in the first sentence of its abstract that, "Fibrosis is the formation of excessive fibrous connective tissue in an organ or tissue, which occurs in reparative process or in response to inflammation. Fibrotic diseases are characterized by abnormal excessive deposition of fibrous proteins, such as collagen, and the disease is most commonly progressive, leading to organ disfunction and failure" The September issue of the Journal of the Science of Food Agriculture looked at pomegranate juice's ability to stop or at least slow down both inflammation and fibrosis. "The high-fat, high sugar diet plus pomegranate juice group had significantly lower hepatic steatosis, ballooning, lobular inflammation and portal inflammation; lower hepatic pro-inflammatory and pro-fibrotic gene expression."
What does all of this mean to you, the patient who is struggling with CHRONIC PAIN or Chronic Illnesses, including autoimmune diseases or funky neurological problems? It means that you can't go another day without addressing your inflammation / fibrosis. Which raises the question of how best to go about accomplishing this. My suggestion is to start with the short, simple post I created for this very purpose. Consider it my Christmas gift to you since I'm providing it to you free of charge. It's easy to follow and cheap to implement (HERE IT IS).
THE INFLAMMATION, SCAR TISSUE, DEGENERATION CONUNDRUM: THE THREE HORSEMEN OF CHRONIC PAIN AND DISEASERead Now
THE THREE HORSEMEN OF CHRONIC PAIN
INFLAMMATION, SCAR TISSUE / FIBROSIS, AND DEGENERATION
STOP THE VICIOUS CYCLE OF PAIN & DISEASE
"When inflamed tissue is repeatedly agitated, the chronic exposure to an inflamed region can lead to chronic inflammation and excessive tissue breakdown and result in tissue degeneration. Inflammation may become disrupted and prolonged when the tissue is continually subjected to repetitive or forceful activities. This can lead to a vicious cycle of injury, local inflammation, systemic inflammation, fibrosis, and tissue degeneration. These subsequent changes result in pain, loss of motor function, and depression / anxiety. The systemic effects of exposure to inflammatory mediators should not be ignored." Cherry-picked from Michael Higgins' book, Therapeutic Exercise: From Theory to Practice.
- INFLAMMATION: Inflammation is the name of a group of chemicals (HERE) that allows your cells to communicate with one another. They are a vital part of any healing process. However, inflammation is another one of the many areas where too much of a good thing can become a bad thing ---- in this case a very bad thing. Inflammation comes in two flavors, local and systemic. A local inflammation is typically caused by some sort of local injury (a SPRAINED ANKLE for example) or INFECTION. A "SYSTEMIC INFLAMMATION" is inflammation running rampant throughout your entire body. The worse the systemic problem, the more likely you are to find an underlying LEAKY GUT. Be aware that Inflammation is the centerpiece of almost every chronic health problem you can name --- even many (probably most) that have been touted as "GENETIC".
- FIBROSIS / SCAR TISSUE: Fibrosis is a synonymous term for Scar Tissue (HERE). Although you will hear me use either (as well as the term "DENSIFICATION"), when speaking to patients I typically use 'Scar Tissue' for the simple reason that people are familiar with the word and tend to understand the concept better. SCAR TISSUE is tissue, which, instead of its cells lining up in a neat and orderly parallel fashion to each other, is tangled, wadded, and twisted --- sort of like the difference between well-combed hair and a hair tangle (HERE). Scar Tissue is very different than normal tissue in several major ways, including the fact that it is weaker, less elastic, and more pain-sensitive --- as much as a thousand times more pain-sensitive (HERE).
- DEGENERATION: Degeneration is exactly what it sounds like --- something is wearing out. It is important to understand that degeneration can happen to any organ, organ system, or tissue, in your body. It is also important to understand that no matter how often your doctor repeats it, birthdays are not automatically associated with degeneration. If we live long enough, sure; we're all going to go through some degree of the stuff. But the whole, "After all Mrs. Jones, you just aren't as young as you used to be" is for the birds --- even though it is a convenient scapegoat for virtually all health-related problems.
When your body is functioning properly, everything is right with the world. However, when any of these three bullet points get tipped out of balance (particularly the first), a "vicious cycle" begins, which feeds itself until you end up in debilitating pain. Or worse yet; six feet under (HERE). A vicious cycle is defined as, "a sequence of reciprocal cause and effect in which two or more elements intensify and aggravate each other, leading inexorably to a worsening of the situation." In other words, A causes B, but B causes A. It's a cycle that feeds itself, and the faster it turns, the faster it will turn. And as you will see, even though I refer to it as "Chronic Pain's Vicious Cycle," you'll see that this cycle goes way beyond pain.
Andrikkos is the author of the animated arrow below
- INFLAMMATION CAUSES FIBROSIS: I've previously provided tons of info on this phenomenon (HERE, HERE, HERE, and HERE). Be aware, however, that inflammation is a critical part of the healing process. When it comes to the musculoskeletal system in particular, inflammation must sometimes be induced in small, local amounts via "HARSH METHODS" in order to stimulate healing processes.
- INFLAMMATION CAUSES DEGENERATION: A great example of this phenomenon is Tooth Decay (HERE). For decades, mainstream dentistry told patients that cavities were caused by the acid from bacteria. Not that this is not true on some level, but ultimately, it's inflammation that causes teeth (not to mention bones) to rot. But there's much more to it than that. The December 2004 issue of the Annals of the New York Academy of Sciences carried a study called Inflammation and the Degenerative Diseases of Aging, which spilled the beans about inflammation and degeneration. "Chronic inflammation is associated with a broad spectrum of neurodegenerative diseases of aging. Included are such disorders as Alzheimer's, Parkinson's disease, ALS, all of the tauopathies, and age-related macular degeneration. Also included are such peripheral conditions as osteoarthritis, rheumatoid arthritis, atherosclerosis, and myocardial infarction (heart attack). Chronically sustained at high levels, inflammation can seriously damage viable host tissue." The "damage" being referred to in the last sentence is ultimately one of two things --- fibrosis or degeneration --- or both. The point is moot, however, because....
- FIBROSIS CAUSES DEGENERATION: Think about it this way using ARTHRITIS or ADHESED FASCIA as an example. Arthritis (arthr = joint) + (itis = inflammation) will always, for any number of reasons, cause an inflexibility and lack of normal motion in tissues. How big of a deal is this? Think about it this way. After almost any kind of surgery, the nurses have the patient up and walking around while they are still groggy from anesthesia. Why is this? It has been known for decades that not only does lack of normal motion cause degeneration (HERE), but it does not take long for said degeneration to begin to set up like an unholy form of concrete.
- DEGENERATION CAUSES FIBROSIS: As joints deteriorate, they move worse. Worse movement causes more degeneration. That same lack of motion also happens to cause increasing amounts of Fibrosis. For instance, DJD causes joints to both thicken and stiffen, leaving the surrounding musculature and connective tissues weak and inflexible, which in turn causes more of the same.
- DEGENERATION CAUSES INFLAMMATION: Cellular death (known as apoptosis or necrosis depending on the context) causes the contents of cells to rupture into the interstitial fluid. Among other things, this causes the chemicals that we collectively refer to as "inflammation" to gain access to a method whereby they can be carried to other areas. One way to describe degeneration would be to say that there is increasing amounts of cellular death occurring. Thus, any time we have increased cellular death, whether due to age or injury, we are going to get a spike in local inflammation, and possibly even systemic inflammation.
What does all of this mean to you, the patient? It means that while Inflammation is the obvious driver of the process, the cycle can, to some degree, be driven from either of the other two corners of the triangle (Fibrosis or Degeneration). It is a true "Vicious Cycle". And in the triangular diagram above, it's even worse because we have three variables feeding each other instead of two. FYI, I used to think of this process in terms of being a more linear-looking loop, which is bad enough as it can also act as a vicious cycle. No matter how you choose to think of it, Inflammation always leads to Fibrosis, which always leads to Degeneration. Repeat.
If treating symptoms actually worked, you wouldn't be reading this post at 2:00 am with tears in your eyes. Sure, the "BIG FIVE" is going to help you with your pain.... But the relief is short-lived, coming with any number of brutal side effects, one of which is ADDICTION. Face it folks; if drugs worked, Americans would have the best health on the planet. But instead, according to our own government's statistics, even though we only make up about 3% of the world population, we consume 75% of the world's drugs (HERE). And you won't believe how bad our collective health really is. Overall, we rank consistently about thirtieth in the world. Despite all our fabulous technological advances in the field of medicine, there's only one way to solve this particular problem. Go to your toolbox and pull out the monkey wrench.
THROWING A MONKEY WRENCH
IN CHRONIC PAIN'S VICIOUS CYCLE
Fortunately for you, I'm into sharing DIY methods for regaining your health and getting out of pain (HERE'S ONE I made for solving back pain). It's all free of charge. That would be free as in "free" ---- no strings attached. I like giving people tools that they can use on their own, and that don't cost a lot of money to implement. The fact is, inexpensive (or free), uncomplicated, and rapid-acting, are exactly what most people are looking for as far as solutions to anything are concerned. And contrary to popular belief, it's possible to accomplish this with even some of the most stubborn health-related problems. But it has to be done properly.
Continually searching for pathology when your problems are "functional" is not going to do it (HERE). More doctor visits, tests, and medications, won't do it either. There is no magic bullet. What I've done for you is to lay some groundwork to provide a simple, generic solution that will help many, if not most of you on at least on some level. And the extra cool thing about it is that UNLIKE THE PRACTICE OF MEDICINE, the side effect profile of this protocol is almost non-existent. There's never been a better time than today to turn over a new leaf.
Using even some of the strategies found in THIS POST will allow you to start breaking the vicious cycle at all three corners. But most importantly, it deals with inflammation. If you can't at least put the breaks on the inflammation, you have little chance of truly improving your health and getting out of pain. It's the very reason that some of you reading this have not had the results you were hoping for with your chiropractor, therapist, or physician. Although there may be other things you need to do along the way, the bottom line is that you must break the cycle.
THE INFLAMMATION SCAR TISSUE CONNECTION
THE BEAT GOES ON
The first thing I want you to realize is that Scar Tissue is not all bad. Your body is going to heal an injury one way or another, and Scar Tissue is how this is accomplished. The key is how the Scar Tissue heals. In order to understand what I am talking about, you have to understand Inflammation. To show you how it all works, I am going to touch on some of the highlights of the pathology textbook I used in school (Basic Pathology: 4th Edition by Robbins and Kumar, 1987).
The second chapter of the book clearly shows the intimate relationship between Inflammation and the healing process. How do I know this? Honestly it's a no-brainer --- it's called Inflammation & Repair. "The inflammatory process... paves the way for repair of the damaged site." In other words, Inflammation is critical to the healing process. But it's also important to remember that Inflammation is not all the same stuff, and is not always your friend. Too much Inflammation (particularly "SYSTEMIC INFLAMMATION") can cause problems ("in some instances the inflammatory-reparative process may be harmful"). Remember that it's typically the "chronic" (long-standing) or 'whole body' inflammation that causes the CRAZY NUMBER OF HEALTH-RELATED PROBLEMS.
According to the text's authors, repair occurs most, "often by fibroblastic scar-forming cells." These cells are the FIBROBLASTS I have spoken of any number of times. Listen to their brief description of the dance that takes place between inflammation and repair.
"Although inflammation and repair are two somewhat distinct processes, they are closely interwoven in the response of tissues to injury. Inflammation dominates the early events and repair assumes major importance later. Nevertheless, repair begins early in the inflammatory response, although it reaches completion only after active inflammation has subsided."
What does this really mean? It means that if you are chronically inflamed, you will perpetually make Scar Tissue / Fibrosis (HERE). If you don't believe this is a big deal as far as both morbidity (sickness) and mortality (death) are concerned, take a look at these two quotes, the first from the website of pharmaceutical giant, Shanghai Genomics (R&D / Inflammation and Fibrosis), and the second from a podcast by Dr. William Wong, a naturopath with a Ph.D in Exercise Physiology (The Number One Cause Of All Disease, Fibrosis & Inflammation....). "Fibrosis remains the leading cause of death in the United Sates; approximately 45% of deaths are related to fibrosis, doubling the number of cancer related deaths." (HERE is the source for this insane statistic.) "Inflammation and fibrosis are connected to every major disease that takes down mammals." Robbins & Kumar would likely agree, going on to say that....
"Repair of destroyed cells therefore usually involves some connective tissue proliferation with the formation of a fibrous scar. Although the anatomical continuity of the of the tissue may be restored, such repair is obviously imperfect since it replaces functioning parenchymal cells with non-specialized connective tissue. Scarring diminishes the reserve of the organ or tissue involved."
In plain English; although the organ or tissue may look OK to the naked eye, Scar Tissue has wreaked its havoc. This 'havoc' is not only in the form of biomechanical dysfunction ("the loss of function can be explained on mechanistic grounds") or neuromechanical pain ("there is reason to believe that chemical mediators such as bradykinin and prostaglandins are also involved"), but in microscopic structural and functional damage to the organs as well. That's right, almost anything that goes wrong with an organ is related, at least to a large degree, to the process of Fibrosis (see previous link). The text book's authors go on to talk about some of the specifics of wound healing.
"Collagen content of the wound reaches normal levels by 60 to 70 days, at a time when the wound has recovered only 25 to 35% of its strength..... There is a progressive increase in tensile strength up to day 100, during which 70 to 90% of the strength of unwounded skin is achieved..... Both experimental and clinical observations indicate that severe protein depletion impairs wound healing."
This is an interesting quote on all levels. First we see that regaining the strength of injured tissue takes a significant amount of time (at least three months, although current research shows that it sometimes takes significantly longer). It also says that "skin" is only, at the very best, be 90% as strong as it was before the injury. While strong skin is certainly a plus, it is not the tissue I am interested in for this post. Strong skin is not nearly as big a deal as strong LIGAMENTS, FASCIA, MUSCLES, or TENDONS.
Newer research says that at the very best, scars in these particular tissues will only heal to 60-70% of normal --- a big reason it is always easier to re-injure said areas (i.e. SPRAIN AN ANKLE and it's always easier to sprain it again). And while I'm sure the "severe protein depletion" the authors are talking about here involves something more along the lines of starvation, the quote leaves something to think about for those who eat a vegan diet as opposed to something more akin to PALEO. What do others say about these "weakened" Scar Tissues?
- "When ligaments, tendons and muscles are torn, the body replaces a rather neat, organized network of a combination of yellow elastic, and dense white non-elastic collagen fibers, with a rather haphazard array of dense white connective scar tissue. This scar tissue will help hold bones together (aka: Joints), but doesn't have the same type and combination of strength and resiliency that the original connective tissue had...... Thus restricting range of motion and causing the patient to become more prone to re-injury. Break a bone and it heals. Strain or sprain soft tissue and it's like trying to glue a piece of plastic back together. It just never comes out as good as the original, is weaker and prone to breaking again." Dr. Todd Narson of Miami Beach Family and Sports Chiropractic (Why A Soft Tissue Injury Can Be Worse Than A Broken Bone). I knew Dr. Todd, as well as his sister, from our days at Logan.
- John Miller of Physioworks (Soft Tissue Injury? What are the Healing Phases?) talks of the "Remodeling Phase" of soft tissue injury, splitting it up into two different phases. "Your body does not magically just stop tissue healing at six week post-injury. Healing is a continuum. At six weeks post-soft tissue injury your healing tissue is reasonably mature but as you stretch, strength and stress your new scar tissue, it often finds that it is not strong enough to cope with your increasing physical demand. When your body detects that a repaired structure is still weaker that necessary, it will automatically stimulate additional new tissue to help strengthen and support the healing tissue until it meets the demands of your normal exercise or physical function..... Ongoing repair and remodeling beyond three months is referred to as the chronic phase and probably refers mainly to pain that lasts more than 3 months."
- And finally, from Brad Walker, widely know as the "Stretch Coach," we have Pulled Muscles, Scar Tissue and Re-Injury. "Scar tissue is made from a very tough, inflexible fibrous material. This fibrous material binds itself to the damaged soft tissue fibers in an effort to draw the damaged fibers back together. What results is a bulky mass of fibrous scar tissue completely surrounding the injury site. In some cases it’s even possible to see and feel this bulky mass under the skin. When scar tissue forms around an injury site, it is never as strong as the tissue it replaces. It also has a tendency to contract and deform the surrounding tissues, so not only is the strength of the tissue diminished, but flexibility of the tissue is also compromised."
WHAT ABOUT STEROIDS & SIMILAR DRUGS?
Let's head back to the text and see what the authors (both pathologists, Dr. Robbins from Harvard and Dr. Kumar from University of Texas) had to say clear back in 1987 about using corticosteroids for soft tissue injuries.
"There is evidence that steroids impair formation of.... mature collagen. Steroids seem to suppress virtually every step of the inflammatory reparative response."
Does anyone remember the article I wrote called IMMUNE SYSTEM SUPPRESSION: AMERICA'S NUMBER ONE MEDICAL THERAPY? In it I addressed both CORTICOSTEROIDS and NSAIDS (anti-inflammatory medications). If you are interested in seeing the four phases of soft tissue healing, it can be found HERE. Think for a moment about suppressing or inhibiting every step of said process(s) of healing. Oh, you might have suppressed some of the pain all right --- at least for the short term --- but you've just set the table for future problems. It's not like Robbins and Kumar are alone in this assessment.
Dr. John Kellett, author of Back Pain, Acute Soft Tissue Injuries, Mobilization, and Fibromyalgia from the October 1986 issue of Medicine and Science in Sports and Exercise said 30 years ago, "Steroids have a deleterious effect on collagen, and direct injection into collagen may produce a permanent reduction in tensile strength." If taken for injuries to the Connective Tissues, "steroids have no sound biological basis," because they "retard fibroblastic activity and may well delay healing. Corticosteroids have little part to play in the management of soft tissue injuries." To see why this is, take a moment to read about "CORTICOSTEROID-INDUCED DEGENERATION".
One year later, in a scientific paper called Acute Soft Tissue Injuries: A Review of the Literature, the renowned Dr. Kellett wrote of NSAIDS, "Use of these drugs, if given, should be restricted to a maximum of three days following injury. Any anti-inflammatory action lasting beyond this period would, theoretically, at least be detrimental since the repair mechanism (phase 2 of healing) is itself an inflammatory process. Little data exist to support the routine use of NSAIDs in athletes with acute pain syndromes (despite advertisements extolling their benefits)".
Yet despite everything we know, not only from our textbooks, but from dozens upon dozens of studies and scientific papers from peer-reviewed journals published in the three decades since (HERE is one from 2017), the medical community continues to push the very drugs that not only inhibit the healing of soft tissues at "every step," but actually destroys said tissues. Sometimes I wonder if doctors have a clue about the intimate relationship between Inflammation & Repair. Which brings us to a bit different sort of Inflammation --- Chronic Inflammation.
CHRONIC INFLAMMATION AND ITS
EFFECTS ON THE HEALING PROCESS
"There are some settings in which chronic inflammation is initiated as a primary process. Often the injurious agents are of low toxicity in comparison with those leading to acute inflammation. Three major groups can be identified. One, persistent infections. Two, prolonged exposure to non-biodegradeable material. And three, autoimmune reactions / autoimmune diseases."
- Persistent infections are either sub-clinical viral or bacterial infections (Epstein/Barr Virus for example, or a low grade infection IN THE MOUTH, or UNDERNEATH A ROOT CANAL), or various forms of DYSBIOSIS (MOLD, YEAST, SIBO, etc, etc, etc). The problem with persistent infections is that they are usually treated with the very thing that likely caused them in the first place --- ANTIBIOTICS. If you are interested in solving your infectious problem, you'll first have to figure out what it's going to take to get yourself off this class of drug (HERE is a good starting point).
- Prolonged exposure to non-biodegradeable material could mean any number of things. It could be a constant exposure to things like lead, ALUMINUM, MERCURY, or even PLASTICS OR OTHER ENDOCRINE DISRUPTORS. The example that was given by Robbins & Kumar was inhaled silica particles. Interestingly enough, I have seen all sorts of ugly reactions (autoimmune) to the silica that leaks from breast implants (nope ladies, they're not worth it).
- Autoimmune diseases have become a raging epidemic here in America (HERE). "In these diseases, autoantigens evoke a self-perpetuating immunologic reaction that results in several chronic inflammatory diseases, such as rheumatoid arthritis." See the previous bullet point.
Their list is fine, but it is missing the boat as far as at least one critical aspect of inflammation is concerned. It completely fails to account for diet. For instance, peer-review has shown us that certain foods (GLUTEN, FOR INSTANCE) are heavily associated with autoimmunity of all sorts, and that sugar itself is massively inflammatory (HERE). Secondly, Inflammation and Autoimmunity are a two-way street. The quote above makes it look like Autoimmunity causes Inflammation, when the opposite is just as (or even more) likely. And finally (I just wrote about this THE OTHER DAY), the very same inflammation that is associated with musculoskeletal pain and dysfunction is also responsible for most disease processes, including the heavy hitters like DIABETES, CANCER, and HEART DISEASE.
What should you do about Inflammation? As far as 'Acute Inflammation' is concerned; for minor injuries, let it ride. I usually think about trying to control acute inflammation like I think about trying to control FEVER (which is actually one of the five cardinal signs of Inflammation). Don't try and squelch it unless the injury is really severe, and then only in a very careful and specific manner that does not inhibit the healing process (HERE). As for dealing with Chronic Inflammation, it's potentially a bit tougher. But if you value your health, you cannot choose to neglect it.
Should you fail to address your Chronic Inflammation, solving your CHRONIC INFLAMMATORY DEGENERATIVE DISEASES or AUTOIMMUNE DISEASES could prove extremely difficult --- maybe even to the point of impossible. But it is possible if you follow the proper steps. For instance, HERE and HERE are very cool testimonials from women who kicked severe Autoimmune Diseases using nothing more than diet --- after being told they would live the rest of their young lives in misery, getting progressively worse until they were virtually debilitated. I've actually created a protocol that gives struggling people a place to start researching (HERE). Don't forget to check out our FACEBOOK PAGE while you are at it.
INFLAMMATION & FIBROSIS
INFLAMMATION'S RELATIONSHIP TO THE MICROSCOPIC SCAR TISSUE THE MEDICAL COMMUNITY CALLS "FIBROSIS"
Although I have shown you in several different posts that Inflammation leads to Scar Tissue / Fibrosis (HERE, HERE, HERE , and HERE are some that come immediately to mind), I'm going to play this game a little differently today. Today I am going to show you, using studies from peer-reviewed journals from the past few months (many are from the past week) just how intimate the relationship between Inflammation and Fibrosis really is.
Pay attention because although some of these quotes contain a fair bit of technical jargon, you can read between the lines to understand their point. You are going to see that this topic of Inflammation and Fibrosis covers a lot of ground. And believe me when I tell you that if I wanted, I could literally have come up with thousands of similar.
There it is folks. Although we know that Inflammation-induced Fibrosis is destroying lives like there's no tomorrow, the medical community continues to scratch their collective heads as far as what to do about it. Sure, NSAIDS and CORTICOSTEROIDS are popular in our society, but we found out a long time ago that these are not all they've been cracked up to be. They destroy the immune system instead of making it healthier.
"Cigarette smoke exposure in mice resulted in respiratory bronchiolitis with fibrosis in surrounded alveoli. The presence of areas of interstitial and alveolar fibrosis in peripheral parenchyma often accompanied the bronchiolar changes. Macrophages from smoking mice elaborate M2 cytokines [Inflammation] and enzymes, which can promote TGF-beta expression [Inflammation], collagen deposition [Scar Tissue], and fibrosis in the surrounding areas." Cherry-picked from the abstract of the March, 2015 issue of PLoS One (Smoking p66Shc Knocked Out Mice Develop Respiratory Bronchiolitis with Fibrosis but Not Emphysema)
CIGARETTE SMOKE is absurdly Inflammatory. Inflammation leads to Fibrosis, and sooner or later, Fibrosis is going to kill you, in this case probably in a slow and miserable fashion.
"Several inflammatory diseases including scleroderma and atopic dermatitis display dermal thickening, epidermal hypertrophy, or excessive accumulation of collagen [Fibrosis]. Strikingly, injection of recombinant soluble LIGHT [an Inflammatory marker from the TNF Family] into mice, either subcutaneously or systemically, promoted collagen deposition in the skin, and dermal and epidermal thickening [Fibrosis]. We reveal an unappreciated activity of LIGHT on keratinocytes and suggest that LIGHT may be an important mediator of skin inflammation and fibrosis in diseases such as scleroderma or atopic dermatitis." Taken from the abstract of the March, 2015 issue of the Journal of Investigative Dermatology (The Tumor Necrosis Factor Superfamily Molecule LIGHT Promotes Keratinocyte Activity and Skin Fibrosis)
According to December's issue of Pediatrics (Atopic Dermatitis: Skin-Directed Management) more than 10% of American children have atopic dermatitis, otherwise known as Eczema. Like all these "Inflammatory" problems we are mentioning today, medical options are limited. I realize your doctor will give you some sort of Cortisone-based cream. But if they are willing to be brutally honest with you, they'll tell you it makes it worse in the long run --- and that doesn't even begin to deal with side-effects --- the majority or which are severely UNDER-REPORTED.
"These findings suggest that IGFBPrP1 acts as an initiator of liver fibrosis by inducing inflammation, HSC activation and Extracellular Matrix deposition [a hallmark of Fibrosis] through the ERK1/2 pathway." The conclusions of a study from the January, 2015 issue of Hepatology International (Insulin-Like Growth Factor Binding Protein-Related Protein 1 (IGFBPrP1) Contributes to Liver Inflammation and Fibrosis Via Activation of the ERK1/2 Pathway)
Bottom line is that living the HIGH CARB LIFESTYLE will eventually earn you fatty and fibrotic liver.
"This study aims to investigate the histopathological changes secondary to the administration of Ankaferd Blood Stopper® (ABS) [a Turkish plant-based drug] into the auricular cartilage. The ABS group had significantly higher level of fibrosis, necrosis, foreign body reaction, inflammation, and cartilage degeneration, compared to the controls.... significantly increased fibrosis and necrosis in the auricular cartilage." From the January, 2015 issue of the International Journal of Clinical and Experimental Medicine (Unpredicted Effects of Ankaferd® on Cartilage Tissue).
Should we be surprised that a drug has the side-effects of both Inflammation and Fibrosis (among other things)? Of course not.
"Radiation therapy is a cornerstone in nasopharyngeal cancer treatment. However, it can induce acute and long-term adverse effects, such as acute mucositis [Inflammation] and late submucosal fibrosis" From this week's issue of the American Journal of Rhinology & Allergy (Nasal Cytological Changes as Late Effects of Radiotherapy for Nasopharyngeal Cancer)
It's not news that the VERY TESTS that physicians use to diagnose Cancer, actually cause Cancer. Neither is it news to anyone that even though it's used as a treatment for cancer, therapeutic radiation itself is a major cause of cancer as well. We know that CANCER is in the family of "INFLAMMATORY DISEASES". Now we see that "Radiation Therapy" causes both Inflammation and Fibrosis. Again; knowing what we know, no one is too surprised. HERE, have another Twinkie.
"The pathological change of kidney in diabetic nephropathy is represented by hypertrophy, inflammation, and renal fibrosis. These results demonstrate that Oryeongsan [an herb used in Chinese Medicine] has protective effect against renal proliferation, fibrosis, and inflammation. Therefore Oryeongsan may be specific therapies targeting renal dysfunction leading to diabetic nephropathy." From the February, 2015 issue of BMC Complementary and Alternative Medicine (Oryeongsan Suppressed High Glucose-Induced Mesangial Fibrosis).
Wow; certain herbs can actually protect against the Inflammation and Fibrosis that come about as the result of BLOOD SUGAR DYSREGULATION --- one of those things that most who are deeply involved in the SCAM KNOWN AS EVIDENCE-BASED MEDICINE (including the FDA) don't want you to know about.
"Secondary lymphedema in humans is a common consequence of lymph node dissection (LND) to treat breast cancer. A peculiar characteristic of the disease is that life-long swelling often precipitously appears several years following the surgical treatment, often due to an inflammatory stimulus. In order to clarify the role of fibrosis in secondary lymphedema initiation, we chemically increased fibrosis in rodent tissues with bleomycin... We found that bleomycin injections exacerbated fibrotic matrix deposition, reduced wound closure, and impaired the ability of the lymphatics to regenerate and reduce the swelling. The findings demonstrate that fibrosis reduces the lymphatic capacity to functionally regenerate and prevent the chronic appearance of lymphedema." Cherry-picked from the abstract of this week's issue of the American Journal of Physiology. Heart and Circulatory Physiology (Fibrosis Worsens Chronic Lymphedema in Rodent Tissues).
BREAST CANCER is not only an epidemic in this country, it's not typically caused by what you have been led to believe the medical community says it's caused by (HERE). Once you understand that Bleomycin is an ANTIBIOTIC, and you begin to understand how Anti-inflammatory Drugs and Antibiotics work to suppress the Immune System (HERE), you can begin to appreciate this drug's wide ranging side effects --- including Inflammation and Fibrosis as well as cancer (HERE).
"Myocarditis is a critical inflammatory disorder which causes life-threatening conditions. No specific or effective treatment has been established. Administration of the DPP-4 inhibitor remarkably suppressed cardiac fibrosis and reduced inflammatory cytokine gene expression in EAM mice." From this week's issue of PLoS One (A DPP-4 Inhibitor Suppresses Fibrosis and Inflammation on Experimental Autoimmune Myocarditis in Mice)
When people die from heart disease, the reality is that they are usually dying of Fibrosis of the heart (HERE). And despite everything you have been led to believe, the therapies we are currently using are not nearly as effective as what TV COMMERCIALS and your doctor have have told you. Great example of this are STATIN DRUGS and DIABETES DRUGS. The problem with giving a specific chemical --- even if it's "natural", such as DPP-4 Inhibitor above ---- is that it tends to throw your body out of HOMEOSTASIS, setting off a chain-reaction of side-effects. It's why so few of these types of drugs pan out in the long run.
"For over 50 years, it has been recognized that immunity contributes to hypertension. Recent data have defined an important role of T cells and various T cell-derived cytokines in several models of experimental hypertension... Cytokines [various forms of Inflammation] released from these cells, including interleukin-17, interferon-γ, tumor necrosis factorα, and interleukin-6 promote..... increased renal fibrosis. Recent experiments have defined a link between oxidative stress and immune activation in hypertension....." From this week's issue of Circulatory Research (Inflammation, Immunity, and Hypertensive End-Organ Damage)
Hypertension (HIGH BLOOD PRESSURE) is rampant in America. I could tell you that it's another one of those Inflammatory (FREE RADICAL) problems that leads to Fibrosis, but you already guessed that after looking at the abstract.
The point is this; if you are not grasping the fact that Inflammation will kill you via a process that restricts normal movement and normal function of your body, right down to the cellular level, odds are great that living a healthy life right up until the very end, is not in your stars. For about 90% of you reading this, THIS POST will effectively address your health problems. The rest of you are going to need some help from someone who understands FUNCTIONAL MEDICINE / FUNCTIONAL NEUROLOGY.
Dr. Schierling completed four years of Kansas State University's five-year Nutrition / Exercise Physiology Program before deciding on a career in Chiropractic. He graduated from Logan Chiropractic College in 1991, and has run a busy clinic in Mountain View, Missouri ever since. He and his wife Amy have four children (three daughters and a son).
Brain Based Therapy
Can You Help
Cardio Or Strength
Cold Laser Therapy
Death By Medicine
Degenerative Joint Disease
D's Of Chronic Pain
Evidence Based Medicine
Gluten Cross Reactivity
Ice Or Heat
Jacks Fork River
Leaky Gut Syndrome
Number One Health Problem
Platelet Rich Therapy
Post Surgical Scarring
Re Invent Yourself
Rib And Chest Pain
Scar Tissue Removal
Sleeping Pills Kill
Stay Or Go
Stretching Post Treatment
Tensegrity And Fascia
The Big Four
Thoracic Outlet Syndrome
Whole Body Vibration