GUT BUGS ARE CRITICAL FOR OVERALL HEALTH & AUTOIMMUNITY PREVENTION
TH-1 DOMINANT DISEASES
THYROID PROBLEMS (Graves / Hashimoto's), 90% of thyroid issues are autoimmune.
Type I Diabetes
Chronic viral infections (PANDA, CMV/EBV, or HERPES are good examples)
ROSACEA or Vitiligo
TH-2 DOMINANT DISEASES
ALLERGIES & ASTHMA, including ECZEMA, histamine intolerance, hives, hay fever, nasal drip, massive mucus production, IgE / eosiniphil response, etc
COPD not caused by smoking
IBD / IBS (Ulcerative Colitis, not Crohn's)
MCS (Multiple Chemical Sensitivity)
CHRONIC FATIGUE SYNDROME (or HERE)
THE TH-17 SYSTEM
A decade ago, a group of rheumatologists published a study (TH17 Cells in Human Disease) in the journal Immunology Review (their bibliography contained 300 books and studies) which concluded... "Our understanding of the role of T cells in human disease is undergoing revision as a result of the discovery of T-helper 17 (Th17) cells, characterized by production of interleukin-17 (IL-17). IL-17 is a highly inflammatory cytokine. Inflammation and pathogenesis induced by Th17 cells is a result of the pro-inflammatory cytokines these cells produce." Some of the specific diseases mentioned in this study that are affected by TH-17 include "psoriasis, inflammatory bowel diseases (IBD), allergic asthma and rheumatoid arthritis (RA), systemic sclerosis / fibrosis, lupus, reactive arthritis, MS, endometriosis [yes, it's autoimmune], VKH, type I diabetes, autoimmune thyroiditis, asthma, allergic disease, atopic dermatitis, eczema, contact hypersensitivity, atopic rhinitis, IBD, periodontal disease, and cancer." The authors also mentioned almost every type of infection (fungal, bacterial, viral, parasitic, mycobacteria, etc, etc) you care to mention.
A very cool study from a 2015 issue of the Journal of Clinical Investigation (Pouring Fuel on the Fire: Th17 Cells, the Environment, and Autoimmunity) had more to say on the topic. From the title, we already know that epigenetics is going to play a huge part in this study. "Unfortunately, the incidence of a number of autoimmune diseases, particularly those in which the IL-23/IL-17 axis has been implicated, has risen in the last several decades, suggesting that environmental factors can promote autoimmunity." What are some of the "environmental" factors specifically mentioned by these Harvard researchers? Whether or not your body is in a state of HOMEOSTASIS, Gut health (MICROBIOME), and yes, diet. "Both obesity and dietary fat intake can alter the production of cytokines involved in Th17 differentiation and potentially predispose to the development of autoimmunity." It's why your choice of fats you eat is critical if you want to get healthy and stay healthy! Bottom line concerning TH-17......
"Interactions between diet, the microbiota, and intestinal immune cells can markedly alter both systemic immune function and host metabolism, and this appears to be largely mediated by cytokines, particularly those in the IL-23/IL-17 axis. While the past several decades have seen marked changes in diet, it is also likely that improvements in hygiene, the development of antibiotics, and widespread vaccination have resulted in significant changes in the intestinal microbiota. This raises the possibility that altered regulation of cytokines as a consequence of changes in diet, metabolism, and commensal microbes, particularly in the intestinal microenvironment, may contribute to the increased incidence of autoimmune diseases, especially those involving the IL-23/IL-17 axis."
Re-read that paragraph if you didn't quite grasp it's importance. Researchers from Harvard said (in a round about way of course --- they likely value their careers as much as you or I) that both HYGIENE and VACCINES play a big role in developing autoimmunity. This is why genetics is a dying science --- eipigenetics is where everything is headed (see earlier link). This means that the things you do to your body and put into your body have the power to either turn on or turn off the genes that experts tout as the root of sickness and disease. In other words, you are not nearly as defined by your genetics as you have been led to believe.
THE AUTOIMMUNITY, DIET, GUT HEALTH, VACCINE, CONNECTION
A 2008 issue of Clinical Reviews in Allergy & Immunology (Infections and Autoimmunity: A Panorama) verified exactly what I showed you earlier; that "Chronic and multiple infections with viruses, such as Epstein-Barr virus and cytomegalovirus, and bacteria, such as H. pylori, may, in susceptible individuals, play a role in the evolvement of autoimmune diseases." Interestingly enough, I've also provided you plenty of information on chronic infection from ROOT CANALS as well as the relationship between H. PYLORI INFECTIONS AND WEAK STOMACH ACID (GERD).
Listen to what the Journal of Autoimmunity had to say about this relationship in a late 2016 study called A Clinical Update on the Significance of the Gut Microbiota in Systemic Autoimmunity. After revealing to us that "in recent years," incidence of certain autoimmune diseases has tripled, the authors revealed why. "...The increasing incidence of autoimmune disease is due to considerable shifts in the bacterial communities resident the gut, collectively known as the gut microbiota, following a change in diet and the widespread introduction of antibiotics. Furthermore, a growing body of evidence suggests that the gut microbiota plays a role in the development of a range of autoimmune diseases including inflammatory bowel disease, multiple sclerosis, type one diabetes and rheumatoid arthritis." If you follow my site you already know all this.
After looking at over 150 studies, researchers from Europe published their review in September's issue of Frontiers in Immunology (Modulation of Multiple Sclerosis and Its Animal Model Experimental Autoimmune Encephalomyelitis by Food and Gut Microbiota), stating that, "Although the cause of MS is not known, the infiltration of peripherally activated immune cells into the CNS has a key pathogenic role. Accumulating evidence supports an important role of diet and gut microbiota in immune-mediated diseases." These authors went on to discuss the fact that MS can be caused, or better yet modulated, by factors that can largely be controlled (ANTIBIOTICS, DYSBIOSIS, MICROBIOME, and even FMT).
Two years ago this month, a Spanish study (Antibiotics and the Human Gut Microbiome: Dysbioses and Accumulation of Resistances) carried by Frontiers in Microbiology showed just how big a factor antibiotics are in the destruction of Gut Health and subsequent development of autoimmunity.
"The human microbiome is overly exposed to antibiotics, due, not only to their medical use, but also to their utilization in farm animals and crops. Microbiome composition can be rapidly altered by exposure to antibiotics, with potential immediate effects on health, for instance through the selection of resistant opportunistic pathogens that can cause acute disease. Microbiome alterations induced by antibiotics can also indirectly affect health in the long-term. The mutualistic microbes in the human body interact with many physiological processes, and participate in the regulation of immune and metabolic homeostasis. Therefore, antibiotic exposure can alter many basic physiological equilibria, promoting long-term disease. Atopic, inflammatory and autoimmune diseases have been linked to gut microbiota dysbiosis, and, in some cases, significant associations have been established between these diseases and the intake of antibiotics during early life. Clearly, the effects of antibiotic-induced dysbiosis will be even more relevant if they occur early in life, a critical period for maturation of the immune system and establishment of immunological tolerance."
July's issue of Microbiome (Control of Lupus Nephritis by Changes of Gut Microbiota) published a study by a team of 20 authors showing that the same thing is likely true of LUPUS. "Systemic lupus erythematosus, characterized by persistent inflammation, is a complex autoimmune disorder with no known cure." But after treating people with Lupus with certain "good" bacteria, the authors concluded that said treatment, "Inside the kidney skewed the Treg-Th17 balance towards a Treg phenotype." If you recall what both of these systems do (Treg -vs- TH-17), it's easy to see why this is huge.
And just last summer, the journal Nature published a collaboration between one of the Ivy League schools (Columbia) and a lab in California (La Jolla Institute for Allergy and Immunology --- an institution whose chief goal is new and improved vaccines) called T Cells from Patients with Parkinson’s Disease Recognize α-Synuclein Peptides that concluded that yes, PARKINSON'S is in fact an autoimmune disease.
I've shown you how big a factor antibiotics are in starting the body down a path to autoimmunity, but now let me talk about diet. I've said forever that in the average chronically sick or chronically inflamed American, antibiotics typically cause the dysbiosis (the ratios of commensal bacteria or other micro-organisms are out of whack), but the situation is propagated by our collective HIGH CARB LIFESTYLES. This thought process is not coming from thin air (although many would claim that's what resides between my ears)
Six years ago, authors from the University of British Columbia published a study in the journal Nutrients called Diet-Induced Dysbiosis of the Intestinal Microbiota and the Effects on Immunity and Disease. Although the gist is readily seen from the title, here are their conclusions.
"The GI tract functions as a major immunological organ as it must maintain tolerance to commensal and dietary antigens while remaining responsive to pathogenic stimuli. If this balance is disrupted, inappropriate inflammatory processes can result, leading to host cell damage and/or autoimmunity. Evidence suggests that the composition of the intestinal microbiota can influence susceptibility to chronic disease of the intestinal tract including ulcerative colitis, Crohn’s disease, celiac disease and irritable bowel syndrome, as well as more systemic diseases such as obesity, type 1 diabetes and type 2 diabetes. Interestingly, a considerable shift in diet has coincided with increased incidence of many of these inflammatory diseases. It was originally believed that the composition of the intestinal microbiota was relatively stable from early childhood; however, recent evidence suggests that diet can cause dysbiosis, an alteration in the composition of the microbiota, which could lead to aberrant immune responses."
This is why the very earliest microbial exposures --- VAGINAL BIRTHS and BREAST-FEEDING YOUR BABIES --- is so darn important! And beyond diet, when you notice that they mention how susceptible the immune systems are in babies and young children, we need to realize that this issue of aberrant immune responses and abnormal tolerance goes beyond diet to the increasingly ridiculous VACCINE SCHEDULE being promoted in Westernized nations. It should concern you that the number of studies on ALUMINUM and it's potential to foul both the microbiome and the brain are increasing exponentially. In fact, I would say that this issue is at critical mass and virtually impossible to hide any longer (although BIG PHARMA continues to try).
Another study from two years later (a collaboration between Yale, MIT, and several European institutions) was published in Current Asthma and Allergy Reports --- Role of “Western Diet” in Inflammatory Autoimmune Diseases. The authors started out by saying, "Developed societies, although having successfully reduced the burden of infectious disease, constitute an environment where metabolic, cardiovascular, and autoimmune diseases thrive." This, folks, is exactly what I have been harping on by continuing to beat my "HYGIENE HYPOTHESIS" drum. Thanks to any number of factors (vaccines included), we see that we have traded acute infectious diseases (FLU is a great example) and most particularly the childhood diseases that everyone used to get, for CHRONIC INFLAMMATORY AND NEUROLOGICALLY DEGENERATIVE DISEASES (not to mention autoimmunity).
"Living in westernized countries has not fundamentally changed the genetic basis on which these diseases emerge, but has strong impact on lifestyle and pathogen exposure. In particular, nutritional patterns collectively termed the 'Western diet,' as well as frequent consumption of processed and ‘fast foods’, promote obesity, metabolic syndrome, and cardiovascular disease. These factors have also gained high interest as possible promoters of autoimmune diseases. This review discusses the current knowledge relative to the association of “Western diet” with autoimmunity, and highlights the role of T cells as central players linking dietary influences to autoimmune pathology"
I would suggest you read these last two studies as they are free online. But reading alone isn't going to solve your problem. What do you plan on doing to get better? The first thing to do is understand that pharmaceutical drugs are not going to solve this problem. But then again, neither are supplements. In the same way that many churchgoing folk would rather give money than time (it's way easier), many chronically ill people --- maybe the majority of chronically ill people --- are looking for a magic bullet in the form of a supplement. In other words, they want to continue with the same detrimental lifestyle that helped get them to this point in the first place, but somehow counteract / antidote it by taking supplements (many of which are touted as "immune system boosters"). In case you haven't heard, MONOTHERAPIES in the absence of lifestyle changes are meaningless for anything other than short term responses.
There are certain foods, however, that settle the immune system. First and foremost among these are good fats --- things like COCONUT OIL, OMEGA THREES, EVOO, avocados, and even SATURATED FATS that come from grass-fed livestock (this would include BUTTER and EGGS as well as meat and poultry). Vitamin D is critical as well (along with two of the other fat soluble vitamins, A & E). And don't forget about GLUTATHIONE. In many cases, fermented foods can also be beneficial. As for probiotics, just remember that while potentially extremely beneficial, they can also cause real problems (HERE, HERE, and HERE).
And while I am not going to list them for you (the internet abounds with lists), it's critical that you grasp the fact that certain herbs tend to stimulate TH-1, while certain herbs stimulate TH-2. What does this mean? Allow me to give you an example of how this could actually work against you. A person who is TH-2 dominant (see the earlier list of TH-2 diseases) gets all excited about anti-inflammatory herbs such as THE YELLOWS, resveratol, dark chocolate, green tea, pycnogenol, quercetin, and who knows what else. Little do they realize that these are all TH-2 stimulants. In other words, if you are chronically ill, study up on this issue and use it to your advantage instead of your detriment.
I get it; the whole thing can get very complex. Bottom line, as your Gut goes, so goes your immune system. It's why natural healers were talking about healing the Gut long before it was popular or supported by mountains of peer-review. How do you solve the two sides of the coin that make up most common Gut problems (DYSBIOSIS and LEAKY GUT)? For starters, take a look at THIS POST.
IS IT PURELY COSMETIC OR A
PORTENT OF CHRONIC HEALTH ISSUES?
Depending on the individual, Rosacea can be triggered by everything from sunlight, to heat, to cold, to certain foods or drinks (alcohol, for instance, is frequently associated with the big red roasceatic nose otherwise known as rhinophyma), to the mites that cause mange, to ENDOCRINE ISSUES, to ROS (free radicals), etc, etc, etc. However, there are numerous studies associating VARIOUS KINDS OF DYSBIOSIS with Rosacea, one of the most common being something known as SIBO (Small Intestinal Bacterial Overgrowth), which is itself intimately related to IBS (Irritable Bowel Syndrome -- recently discovered to be an autoimmune disease).
For instance, back in 2010, the June issue of Clinical Gastroenterology and Hepatology (Increased Incidence of Small Intestinal Bacterial Overgrowth During Proton Pump Inhibitor Therapy) showed that among the several hundred patients studied, "SIBO was detected in 50% of patients using PPIs, 24.5% of patients with IBS, and 6% of healthy control subjects." I've previously shown you not only how bad PPI'S are for both overall and GUT HEALTH, but I've shown you that because they weaken one of the body's first defenses against microbial invaders (strong stomach acid --- see next link), they are heavily associated with H. PYLORI as well. In fact, listen to the conclusions of a study published in the World Journal of Gastroenterology (Extra-Intestinal Manifestations of Helicobacter Pylori: A Concise Review).
"Those of Northern European and Celtic origins appear to be at highest risk of rosacea. It is estimated that the prevalence of rosacea is 1%-10% in fair-skinned populations. Generally, adults over the age of 30 are affected and occurs more often in females. It is thought that inflammation plays a crucial role in its pathogenesis. Inflammatory mediators from an altered innate immune response leading to generation of reactive oxygen species (ROS) such as nitric oxide appear to be part of the mechanisms of disease. Current evidence most supports extraintestinal manifestations with H. pylori in immune thrombo-cytopenic purpura, iron deficiency anemia, urticaria, Parkinson’s, migraines, and rosacea."
Although there are a number of bacteria that pop up as potential culprits, research keeps pointing to H. Pylori as the chief pathogen in developing Rosacea. A three month old study from Clinical, Cosmetic and Investigational Dermatology (Rosacea and Helicobacter Pylori: Links and Risks) essentially confirmed this by concluding, "Microorganisms have been addressed in a variety of studies as pathogenic factors. Mite-related bacteria, staphylococcus epidermidis, chlamydia pneumonia, bacterial toxins, and antimicrobial peptide." Which brings me to another issue we need to address; what are antimicrobial peptides.
Antimicrobial peptides are simply proteins that have antibiotic properties (MOST PHARMACEUTICAL DRUGS DO AS WELL). While this can be a good thing in the case of peptides, if these proteins get out of balance in your body, they cause dysbiosis. A great example is found in a study from a decade old issue of Nature Medicine (Increased Serine Protease Activity and Cathelicidin Promotes Skin Inflammation in Rosacea). In this study it was noted that, "Acne rosacea is an inflammatory skin disease that affects 3% of the US population over 30 years of age and is characterized by... the release of cathelicidin antimicrobial peptides. Here we show that individuals with rosacea express abnormally high levels of cathelicidin in their facial skin and that the proteolytically processed forms of cathelicidin peptides found in rosacea are different from those present in normal individuals."
What studies have repeatedly shown is that individuals with rosacea, SIBO, IBS, and other gut-related problems have something in common as far as treatment is concerned ---- antibiotic therapy frequently resolves their problem. In fact, I addressed this in my last post on FMT (Fecal Microbiota Transplants). The problem is that while antibiotics might be viable for the short term (as long as you are serious about following up with a Gut Health Restorative Protocol --- HERE); over the long haul, if there are no lifestyle changes made, the ANTIBIOTICS WILL MAKE PEOPLE WORSE! 100% of the time. Why? Because when you take antibiotics, you destroy the bacteria that live in your Gut (there's no way around it). This means that you are destroying as much as 80% of your immune system (HERE). Speaking of immune systems, let's briefly look at a study that got a lot of play in the press last year as far as connecting the dots concerning the Rosacea / immune system relationship.
A group of Danish researchers looked at the link between Rosacea and a number of CHRONIC INFLAMMATORY DEGENERATIVE and AUTOIMMUNE DISEASES in over 40,000 patients, almost 2/3 of which were women. What did they find? According to results published in the Journal of the American Academy of Dermatology (Clustering of Autoimmune Diseases in Patients with Rosacea), "Rosacea is a common inflammatory skin condition that shares genetic risk loci with autoimmune diseases such as type 1 diabetes and celiac disease. Rosacea is associated with type 1 diabetes, celiac disease, multiple sclerosis, and rheumatoid arthritis, in women." Having Rosacea doubled the chances of these autoimmune diseases (CELIAC, RA, MS, and T1D).
Besides dealing with underlying INFLAMMATION by addressing Gut Health issues (see earlier links), one interesting Rosacea treatment that I saw come up in the research literature a number of times was LOW LEVEL LASER THERAPY. For instance, September's issue of the International Journal of Women's Dermatology (Laser Treatment of Medical Skin Disease in Women) revealed that, "There are four types of rosacea: erythematotelangiectatic, papulopustular, phymatous, and ocular. Patients may have one or any combination of these types. In the arsenal of treatment for dermatologists, lasers offer a safe and efficacious way to treat some forms of rosacea." There were any number of similar studies specifically touting laser treatment of Rosacea.
Bottom line; you need to deal with Rosacea like you would deal with any number of other health-related issues --- including autoimmune and inflammatory issues. Firstly, remove the triggers that drive the inflammation. Although there are potentially a slew of them; knowing about the intimate relationship between GRAINS and autoimmunity immediately brings gluten to mind (HERE). Secondly, address the lesions themselves with a laser (this is an arena where whoever treats you will have to be very careful around the eyes). While Laser Therapy will not likely solve the long-term underlying causes of the Rosacea, it will likely allow for rapid improvement in its appearance --- a huge morale booster since this disease affects the face. Thirdly, get with the program as far as Gut Health is concerned (and take a closer look at the relationship between GUT HEALTH AND SKIN). Also, it's important to be aware that dysbiosis is almost always associated with some form of "THE LEAKIES".
Dr. Schierling completed four years of Kansas State University's five-year Nutrition / Exercise Physiology Program before deciding on a career in Chiropractic. He graduated from Logan Chiropractic College in 1991, and has run a busy clinic in Mountain View, Missouri ever since. He and his wife Amy have four children (three daughters and a son).
Brain Based Therapy
Can You Help
Cardio Or Strength
Cold Laser Therapy
Death By Medicine
Degenerative Joint Disease
D's Of Chronic Pain
Evidence Based Medicine
Gluten Cross Reactivity
Ice Or Heat
Jacks Fork River
Leaky Gut Syndrome
Number One Health Problem
Platelet Rich Therapy
Post Surgical Scarring
Re Invent Yourself
Rib And Chest Pain
Scar Tissue Removal
Sleeping Pills Kill
Stay Or Go
Stretching Post Treatment
Tensegrity And Fascia
The Big Four
Thoracic Outlet Syndrome
Whole Body Vibration