AGING, INFLAMMATION, THE MICROBIOME, AND FECAL MICROBIOTA TRANSPLANTS
Earlier this month, a dozen researchers from several universities in the Netherlands published a study in Frontiers in Immunology titled Aged Gut Microbiota Contributes to Systemical Inflammaging After Transfer to Germ-Free Mice. What's especially interesting is that it deals with a subject I touched on in YESTERDAY'S POST on fascia and athletic injuries; "Inflammaging". What is inflammaging? It's the combination of two words, 'inflammation' and 'aging'. Although the word has been part of the scientific vernacular for nearly two decades, take a listen to what the experts are saying about inflammaging (BTW, there are over 300 studies with "inflammaging" in the title).
I already know what you're thinking; what the heck does this have to do with FECAL MICROBIOTA TRANSPLANTS -- one of the single hottest areas of research for the past five years? In previous studies, we saw where feces from obese mice was transplanted into thin mice, making them fat. The scientists turned right around and transplanted feces from thin mice back into the fat mice, making them thin. Back and forth, the outward expression of your health intimately related to the inward expression of your MICROBIOME. This is why I have shown you time and time again that overall health is all about GUT HEALTH. Now, take a look at what this brand new study has to say.
"Advanced age is associated with chronic low-grade inflammation, which is usually referred to as inflammaging. Elderly are also known to have an altered gut microbiota composition. However, whether inflammaging is a cause or consequence of an altered gut microbiota composition is not clear. In this study, gut microbiota from young or old conventional mice was transferred to young germ-free (GF) mice. Four weeks after gut microbiota transfer immune cell populations were analyzed. Here, we show by transferring aged microbiota to young GF mice that certain bacterial species within the aged microbiota promote inflammaging. This effect was associated with lower levels of Akkermansia and higher levels of TM7 bacteria and Proteobacteria in the aged microbiota after transfer [dysbiosis]. The aged microbiota promoted inflammation in the small intestine in the GF mice and enhanced leakage of inflammatory bacterial components into the circulation was observed. Moreover, the aged microbiota promoted increased T cell activation in the systemic compartment. In conclusion, these data indicate that the gut microbiota from old mice contributes to inflammaging after transfer to young GF mice."
Living the rest of your life with less inflammation is a noble goal, not so much because it will help you live longer (although it probably will), but because decreasing the amount of systemic inflammation coursing through your system will undoubtedly help you live better. And let's be honest with ourselves for a moment; who really wants to live longer, if the quality of life is terrible? Unfortunately, this is the perfect scenario for generating obscene pharmaceutical profits, and exactly what's going on in most Westernized countries, including America (HERE).
Think about it this way; How many people would purposefully choose to live the rest of their life with the aftermath of a stroke --- or a nasty autoimmune disease --- or cancer, if they could actually have avoided it / them in the first place? For those of you who believe that your specific disease is random or "GENETIC," while certainly possible, is far less likely than you've been led to believe (go back and click on the "epigenetics" link above). While I would never promote anything as a 'sure thing,' I've created a starting point --- a place to start gathering ideas for creating your own exit strategy (HERE) --- a way to start slowing down the medical merry-go-round so that you can get off. If you find this sort of thing intriguing, be sure to spread the wealth by liking, sharing, or following on FACEBOOK.
BRITISH JOURNAL OF SPORTS MEDICINE TACKLES...
Dr. Schierling completed four years of Kansas State University's five-year Nutrition / Exercise Physiology Program before deciding on a career in Chiropractic. He graduated from Logan Chiropractic College in 1991, and has run a busy clinic in Mountain View, Missouri ever since. He and his wife Amy have four children (three daughters and a son).